2cm4 - Revision history

OCA at 07:49, 23 October 2024

2024-10-23T07:49:30Z

← Older revision		Revision as of 07:49, 23 October 2024
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	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/C5I_ORNMO C5I_ORNMO] Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (PubMed:15699138~~) (Probable~~). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably arachidonic acid (AA)) that may be sequestered to interfere with the host inflammatory response (PubMed:23625922). Does not bind to leukotriene C4 and thromboxane B2 (PubMed:23625922). In vivo, when tested on the mouse model of immune complex-induced acute lung injury (IC-ALI), shows a potent inhibitory activity of the pathology, equally dependent on both C5 inhibition and LTB4 binding for full activity (PubMed:23625922).<ref>PMID:15699138</ref> <ref>PMID:23625922</ref> <ref>PMID:27018802</ref> <ref>PMID:17445829</ref>		[https://www.uniprot.org/uniprot/C5I_ORNMO C5I_ORNMO] Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (Probable) (PubMed:15699138). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably arachidonic acid (AA)) that may be sequestered to interfere with the host inflammatory response (PubMed:23625922). Does not bind to leukotriene C4 and thromboxane B2 (PubMed:23625922). In vivo, when tested on the mouse model of immune complex-induced acute lung injury (IC-ALI), shows a potent inhibitory activity of the pathology, equally dependent on both C5 inhibition and LTB4 binding for full activity (PubMed:23625922).<ref>PMID:15699138</ref> <ref>PMID:23625922</ref> <ref>PMID:27018802</ref> <ref>PMID:17445829</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 15:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cm4_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cm4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:21, 13 December 2023

2023-12-13T14:21:15Z

← Older revision		Revision as of 14:21, 13 December 2023
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	<StructureSection load='2cm4' size='340' side='right'caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cm4' size='340' side='right'caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Argasid_tick Argasid tick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2cm9\|2cm9]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [https://pdbe.org/2cm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [https://pdbe.org/2cm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm4 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/C5I_ORNMO C5I_ORNMO] Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (PubMed:15699138) (Probable). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably arachidonic acid (AA)) that may be sequestered to interfere with the host inflammatory response (PubMed:23625922). Does not bind to leukotriene C4 and thromboxane B2 (PubMed:23625922). In vivo, when tested on the mouse model of immune complex-induced acute lung injury (IC-ALI), shows a potent inhibitory activity of the pathology, equally dependent on both C5 inhibition and LTB4 binding for full activity (PubMed:23625922).<ref>PMID:15699138</ref> <ref>PMID:23625922</ref> <ref>PMID:27018802</ref> <ref>PMID:17445829</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Argasid tick]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Boland, W]]~~
	~~[[Category: Johnson, S]]~~
	~~[[Category: Lea, S M]]~~
	~~[[Category: Lissina, O]]~~
	~~[[Category: Nunn, M A]]~~
	~~[[Category: Paesen, G C]]~~
	~~[[Category: Roversi, P]]~~
	~~[[Category: C5]]~~
	~~[[Category: Complement]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Lipocalin]]~~
	~~[[Category: Omci]]~~
	[[Category: Ornithodoros moubata]]		[[Category: Ornithodoros moubata]]
	[[Category: ~~Tick~~]]		[[Category: Boland W]]
			[[Category: Johnson S]]
			[[Category: Lea SM]]
			[[Category: Lissina O]]
			[[Category: Nunn MA]]
			[[Category: Paesen GC]]
			[[Category: Roversi P]]

OCA at 06:58, 1 December 2021

2021-12-01T06:58:23Z

← Older revision		Revision as of 06:58, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2cm4' size='340' side='right'caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cm4' size='340' side='right'caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cm9\|2cm9]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [~~http~~://pdbe.org/2cm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [https://pdbe.org/2cm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:56, 26 February 2020

2020-02-26T10:56:35Z

← Older revision		Revision as of 10:56, 26 February 2020
Line 1:		Line 1:

	==The complement inhibitor OmCI in complex with ricinoleic acid==		==The complement inhibitor OmCI in complex with ricinoleic acid==
	<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cm4' size='340' side='right'caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Argasid tick]]		[[Category: Argasid tick]]
			[[Category: Large Structures]]
	[[Category: Boland, W]]		[[Category: Boland, W]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]

OCA at 08:17, 23 May 2018

2018-05-23T08:17:19Z

← Older revision		Revision as of 08:17, 23 May 2018
Line 1:		Line 1:
	==~~THE COMPLEMENT INHIBITOR OMCI IN COMPLEX WITH RICINOLEIC ACID~~==
			==The complement inhibitor OmCI in complex with ricinoleic acid==
	<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://pdbe.org/2cm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://pdbe.org/2cm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cm4_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cm4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:17, 10 February 2016

2016-02-10T06:17:43Z

← Older revision		Revision as of 06:17, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cm4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:12, 11 September 2015

2015-09-11T06:12:01Z

← Older revision		Revision as of 06:12, 11 September 2015
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	<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ornithodoros_moubata Ornithodoros moubata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://pdbe.org/2cm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cm4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ornithodoros moubata~~]]		[[Category: Argasid tick]]
	[[Category: Boland, W]]		[[Category: Boland, W]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]
Line 42:		Line 43:
	[[Category: Lipocalin]]		[[Category: Lipocalin]]
	[[Category: Omci]]		[[Category: Omci]]
			[[Category: Ornithodoros moubata]]
	[[Category: Tick]]		[[Category: Tick]]

OCA at 16:32, 15 January 2015

2015-01-15T16:32:51Z

← Older revision		Revision as of 16:32, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Ornithodoros moubata]]		[[Category: Ornithodoros moubata]]
	[[Category: Boland, W.]]		[[Category: Boland, W]]
	[[Category: Johnson, S.]]		[[Category: Johnson, S]]
	[[Category: Lea, S M.]]		[[Category: Lea, S M]]
	[[Category: Lissina, O.]]		[[Category: Lissina, O]]
	[[Category: Nunn, M A.]]		[[Category: Nunn, M A]]
	[[Category: Paesen, G C.]]		[[Category: Paesen, G C]]
	[[Category: Roversi, P.]]		[[Category: Roversi, P]]
	[[Category: C5]]		[[Category: C5]]
	[[Category: Complement]]		[[Category: Complement]]
Line 42:		Line 42:
	[[Category: Lipocalin]]		[[Category: Lipocalin]]
	[[Category: Omci]]		[[Category: Omci]]
	~~[[Category: Ornithodoros moubata]]~~
	[[Category: Tick]]		[[Category: Tick]]

OCA at 01:47, 30 September 2014

2014-09-30T01:47:53Z

← Older revision		Revision as of 01:47, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cm4~~.~~png~~\|~~left~~\|~~200px~~]]		==THE COMPLEMENT INHIBITOR OMCI IN COMPLEX WITH RICINOLEIC ACID==
			<StructureSection load='2cm4' size='340' side='right' caption='[[2cm4]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM4 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cm9\|2cm9]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm4 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cm4_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The complement (C) system is a potent innate immune defence system against parasites. We have recently characterised and expressed OmCI, a 16 kDa protein derived from the soft tick Ornithodoros moubata that specifically binds C5, thereby preventing C activation. The structure of recombinant OmCI determined at 1.9 A resolution confirms a lipocalin fold and reveals that the protein binds a fatty acid derivative that we have identified by mass spectrometry as ricinoleic acid. We propose that OmCI could sequester one of the fatty acid-derived inflammatory modulators from the host plasma, thereby interfering with the host inflammatory response to the tick bite. Mapping of sequence differences between OmCI and other tick lipocalins with different functions, combined with biochemical investigations of OmCI activity, supports the hypothesis that OmCI acts by preventing interaction with the C5 convertase, rather than by blocking the C5a cleavage site.

	~~{{STRUCTURE_2cm4\| PDB=2cm4 \| SCENE= }}~~		The structure of OMCI, a novel lipocalin inhibitor of the complement system.,Roversi P, Lissina O, Johnson S, Ahmat N, Paesen GC, Ploss K, Boland W, Nunn MA, Lea SM J Mol Biol. 2007 Jun 8;369(3):784-93. Epub 2007 Mar 30. PMID:17445829<ref>PMID:17445829</ref>

	~~===THE COMPLEMENT INHIBITOR OMCI IN COMPLEX WITH RICINOLEIC ACID===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17445829}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cm4]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ornithodoros_moubata Ornithodoros moubata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CM4 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017445829<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Ornithodoros moubata]]		[[Category: Ornithodoros moubata]]
	[[Category: Boland, W.]]		[[Category: Boland, W.]]

OCA: Protected "2cm4" [edit=sysop:move=sysop]

2013-01-06T11:02:19Z

Protected "2cm4" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:02, 6 January 2013
(No difference)