2cml - Revision history

OCA at 14:22, 13 December 2023

2023-12-13T14:22:46Z

← Older revision		Revision as of 14:22, 13 December 2023
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	==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==		==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==
	<StructureSection load='2cml' size='340' side='right'caption='[[2cml]]' scene=''>		<StructureSection load='2cml' size='340' side='right'caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CML FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [https://pdbe.org/2cml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [https://www.ebi.ac.uk/pdbsum/2cml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cml ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [https://pdbe.org/2cml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [https://www.ebi.ac.uk/pdbsum/2cml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cml ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Crennell SJ]]		[[Category: Crennell SJ]]

OCA at 11:28, 10 February 2021

2021-02-10T11:28:52Z

← Older revision		Revision as of 11:28, 10 February 2021
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	==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==		==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==
	<StructureSection load='2cml' size='340' side='right' caption='[[2cml]]~~, [[Resolution\|resolution]] 2.15Å~~' scene=''>		<StructureSection load='2cml' size='340' side='right'caption='[[2cml]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>~~[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CML FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [https://pdbe.org/2cml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [https://www.ebi.ac.uk/pdbsum/2cml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cml ProSAT]</span></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [~~http~~://pdbe.org/2cml PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cml PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cml ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[[http://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Exo-alpha-sialidase~~]]		[[Category: Large Structures]]
	[[Category: Crennell~~, S J~~]]		[[Category: Crennell SJ]]
	[[Category: Garman~~, E F~~]]		[[Category: Garman EF]]
	[[Category: Laver~~, W G~~]]		[[Category: Laver WG]]
	[[Category: Lukacik, P]]		[[Category: Lukacik P]]
	[[Category: Rudino-Pinera, E]]		[[Category: Rudino-Pinera E]]
	[[Category: Tunnah, P]]		[[Category: Tunnah P]]
	[[Category: Webster~~, R G]]~~		[[Category: Webster RG]]
	~~[[Category: Glycosidase]]~~
	~~[[Category: Hb site]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Influenza type some]]~~
	~~[[Category: Neuraminidase]]~~
	~~[[Category: Sialic acid]]~~
	~~[[Category: Subtype n6]]~~
	~~[[Category: Transmembrane~~]]

OCA at 07:47, 6 March 2019

2019-03-06T07:47:02Z

← Older revision		Revision as of 07:47, 6 March 2019
Line 1:		Line 1:

	==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==		==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==
	<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>

OCA at 06:01, 20 June 2018

2018-06-20T06:01:53Z

← Older revision		Revision as of 06:01, 20 June 2018
Line 1:		Line 1:

	==~~STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE~~ N6 ~~COMPLEXED WITH~~ 30 MM ZANAMIVIR, ~~CRYSTAL SOAKED FOR~~ 3 ~~HOURS AT~~ 291 K.==		==Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.==
	<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 08:04, 23 May 2018

2018-05-23T08:04:44Z

← Older revision		Revision as of 08:04, 23 May 2018
Line 1:		Line 1:

	==STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM ZANAMIVIR, CRYSTAL SOAKED FOR 3 HOURS AT 291 K.==		==STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM ZANAMIVIR, CRYSTAL SOAKED FOR 3 HOURS AT 291 K.==
	<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://pdbe.org/2cml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://pdbe.org/2cml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cml_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cml_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:20, 9 February 2016

2016-02-09T02:20:19Z

← Older revision		Revision as of 02:20, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cml ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 17:39, 10 September 2015

2015-09-10T17:39:43Z

← Older revision		Revision as of 17:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://pdbe.org/2cml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	~~[[Category: Influenza a virus]]~~
	[[Category: Crennell, S J]]		[[Category: Crennell, S J]]
	[[Category: Garman, E F]]		[[Category: Garman, E F]]

OCA at 16:13, 15 January 2015

2015-01-15T16:13:30Z

← Older revision		Revision as of 16:13, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Crennell, S J.]]		[[Category: Crennell, S J]]
	[[Category: Garman, E F.]]		[[Category: Garman, E F]]
	[[Category: Laver, W G.]]		[[Category: Laver, W G]]
	[[Category: Lukacik, P.]]		[[Category: Lukacik, P]]
	[[Category: Rudino-Pinera, E.]]		[[Category: Rudino-Pinera, E]]
	[[Category: Tunnah, P.]]		[[Category: Tunnah, P]]
	[[Category: Webster, R G.]]		[[Category: Webster, R G]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hb site]]		[[Category: Hb site]]

OCA at 03:23, 29 September 2014

2014-09-29T03:23:07Z

← Older revision		Revision as of 03:23, 29 September 2014
Line 1:		Line 1:
	~~[[Image:2cml.png\|left\|200px]]~~		==STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM ZANAMIVIR, CRYSTAL SOAKED FOR 3 HOURS AT 291 K.==
			<StructureSection load='2cml' size='340' side='right' caption='[[2cml]], [[Resolution\|resolution]] 2.15Å' scene=''>
	~~{{STRUCTURE_2cml\| PDB=2cml \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CML FirstGlance]. <br>
	===STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM ZANAMIVIR, CRYSTAL SOAKED FOR 3 HOURS AT 291 K.===		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v0z\|1v0z]], [[1w1x\|1w1x]], [[1w20\|1w20]], [[1w21\|1w21]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	==~~About this Structure~~==		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cml RCSB], [http://www.ebi.ac.uk/pdbsum/2cml PDBsum]</span></td></tr>
	[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA].		<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cml_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
			__TOC__
			</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]

OCA at 12:18, 20 October 2012

2012-10-20T12:18:28Z

← Older revision		Revision as of 12:18, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[2cml]] is a 4 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA].		[[2cml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CML OCA].

	==See Also==		==See Also==