2cmo - Revision history

OCA at 14:22, 13 December 2023

2023-12-13T14:22:47Z

← Older revision		Revision as of 14:22, 13 December 2023
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	<StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [https://pdbe.org/2cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [https://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [https://pdbe.org/2cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [https://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gajhede, M]]		[[Category: Rattus norvegicus]]
	[[Category: Greenwood~~, J R~~]]		[[Category: Gajhede M]]
	[[Category: Kasper, C]]		[[Category: Greenwood JR]]
	[[Category: Kastrup~~, J S~~]]		[[Category: Kasper C]]
	[[Category: Kristensen~~, A S~~]]		[[Category: Kastrup JS]]
	[[Category: Liljefors, T]]		[[Category: Kristensen AS]]
	[[Category: Mirza, O]]		[[Category: Liljefors T]]
	[[Category: Olsen, L]]		[[Category: Mirza O]]
	[[Category: Pickering~~, D S~~]]		[[Category: Olsen L]]
	[[Category: Schousboe, A]]		[[Category: Pickering DS]]
	[[Category: Sigurskjold~~, B W~~]]		[[Category: Schousboe A]]
	[[Category: Watjen, F]]		[[Category: Sigurskjold BW]]
	~~[[Category: Alternative splicing]]~~		[[Category: Watjen F]]
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Ion channel]]~~
	~~[[Category: Ion transport]]~~
	~~[[Category: Ionic channel]]~~
	~~[[Category: Lipoprotein]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Palmitate]]~~
	~~[[Category: Postsynaptic membrane]]~~
	~~[[Category: Receptor]]~~
	~~[[Category: Rna editing]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Transport~~]]

OCA at 05:23, 28 April 2021

2021-04-28T05:23:06Z

← Older revision		Revision as of 05:23, 28 April 2021
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	<StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [~~http~~://pdbe.org/2cmo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [https://pdbe.org/2cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [https://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:56, 26 February 2020

2020-02-26T10:56:53Z

← Older revision		Revision as of 10:56, 26 February 2020
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	==The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209==		==The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209==
	<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]
	[[Category: Greenwood, J R]]		[[Category: Greenwood, J R]]

OCA at 08:17, 23 May 2018

2018-05-23T08:17:59Z

← Older revision		Revision as of 08:17, 23 May 2018
Line 1:		Line 1:
	==~~THE STRUCTURE OF A MIXED GLUR2 LIGAND~~-~~BINDING CORE DIMER IN COMPLEX WITH~~ (S)-~~GLUTAMATE AND THE ANTAGONIST~~ (S)-~~NS1209~~==
			==The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209==
	<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://pdbe.org/2cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://pdbe.org/2cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmo_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>
Line 46:		Line 44:
	[[Category: Sigurskjold, B W]]		[[Category: Sigurskjold, B W]]
	[[Category: Watjen, F]]		[[Category: Watjen, F]]
			[[Category: Alternative splicing]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Ion channel]]		[[Category: Ion channel]]

OCA at 12:59, 7 February 2016

2016-02-07T12:59:15Z

← Older revision		Revision as of 12:59, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cmo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:41, 10 September 2015

2015-09-10T01:41:15Z

← Older revision		Revision as of 01:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://pdbe.org/2cmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cmo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]
	[[Category: Greenwood, J R]]		[[Category: Greenwood, J R]]

OCA at 17:55, 15 January 2015

2015-01-15T17:55:42Z

← Older revision		Revision as of 17:55, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Gajhede, M.]]		[[Category: Gajhede, M]]
	[[Category: Greenwood, J R.]]		[[Category: Greenwood, J R]]
	[[Category: Kasper, C.]]		[[Category: Kasper, C]]
	[[Category: Kastrup, J S.]]		[[Category: Kastrup, J S]]
	[[Category: Kristensen, A S.]]		[[Category: Kristensen, A S]]
	[[Category: Liljefors, T.]]		[[Category: Liljefors, T]]
	[[Category: Mirza, O.]]		[[Category: Mirza, O]]
	[[Category: Olsen, L.]]		[[Category: Olsen, L]]
	[[Category: Pickering, D S.]]		[[Category: Pickering, D S]]
	[[Category: Schousboe, A.]]		[[Category: Schousboe, A]]
	[[Category: Sigurskjold, B W.]]		[[Category: Sigurskjold, B W]]
	[[Category: Watjen, F.]]		[[Category: Watjen, F]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Ion channel]]		[[Category: Ion channel]]

OCA at 05:08, 29 September 2014

2014-09-29T05:08:29Z

← Older revision		Revision as of 05:08, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2cmo~~.~~png~~\|~~left~~\|~~200px~~]]		==THE STRUCTURE OF A MIXED GLUR2 LIGAND-BINDING CORE DIMER IN COMPLEX WITH (S)-GLUTAMATE AND THE ANTAGONIST (S)-NS1209==
			<StructureSection load='2cmo' size='340' side='right' caption='[[2cmo]], [[Resolution\|resolution]] 2.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[1ftm\|1ftm]], [[1fto\|1fto]], [[1fw0\|1fw0]], [[1gr2\|1gr2]], [[1lb8\|1lb8]], [[1lb9\|1lb9]], [[1lbb\|1lbb]], [[1lbc\|1lbc]], [[1m5b\|1m5b]], [[1m5c\|1m5c]], [[1m5d\|1m5d]], [[1m5e\|1m5e]], [[1m5f\|1m5f]], [[1mm6\|1mm6]], [[1mm7\|1mm7]], [[1mqd\|1mqd]], [[1mqg\|1mqg]], [[1mqh\|1mqh]], [[1mqi\|1mqi]], [[1mqj\|1mqj]], [[1ms7\|1ms7]], [[1mxu\|1mxu]], [[1mxv\|1mxv]], [[1mxw\|1mxw]], [[1mxx\|1mxx]], [[1mxy\|1mxy]], [[1mxz\|1mxz]], [[1my0\|1my0]], [[1my1\|1my1]], [[1my2\|1my2]], [[1my3\|1my3]], [[1my4\|1my4]], [[1n0t\|1n0t]], [[1nnk\|1nnk]], [[1nnp\|1nnp]], [[1p1n\|1p1n]], [[1p1o\|1p1o]], [[1p1q\|1p1q]], [[1p1u\|1p1u]], [[1p1w\|1p1w]], [[1syh\|1syh]], [[1syi\|1syi]], [[1wvj\|1wvj]], [[1xhy\|1xhy]], [[2aix\|2aix]], [[2al4\|2al4]], [[2al5\|2al5]], [[2anj\|2anj]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [http://www.ebi.ac.uk/pdbsum/2cmo PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmo_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Ionotropic glutamate receptors (iGluRs) mediate fast synaptic transmission between cells of the central nervous system and are involved in various aspects of normal brain function. iGluRs are implicated in several brain disorders, e.g. in the high-frequency discharge of impulses during an epileptic seizure. (RS)-NS1209 functions as a competitive antagonist at 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionate receptors, and shows robust preclinical anticonvulsant and neuroprotective effects. This study explores 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionate receptor binding and selectivity of this novel class of antagonists. We present here the first X-ray structure of a mixed GluR2 ligand-binding core dimer, with the high-affinity antagonist (S)-8-methyl-5-(4-(N,N-dimethylsulfamoyl)phenyl)-6,7,8,9,-tetrahydro-1H-py rrolo[3,2-h]-isoquinoline-2,3-dione-3-O-(4-hydroxybutyrate-2-yl)oxime [(S)-NS1209] in one protomer and the endogenous ligand (S)-glutamate in the other. (S)-NS1209 stabilises an even more open conformation of the D1 and D2 domains of the ligand-binding core than that of the apo structure due to steric hindrance. This is the first time ligand-induced hyperextension of the binding domains has been observed. (S)-NS1209 adopts a novel binding mode, including hydrogen bonding to Tyr450 and Gly451 of D1. Parts of (S)-NS1209 occupy new areas of the GluR2 ligand-binding cleft, and bind near residues that are not conserved among receptor subtypes. The affinities of (RS)-NS1209 at the GluR2 ligand-binding core as well as at GluR1-6 and mutated GluR1 and GluR3 receptors have been measured. Two distinct binding affinities were observed at the GluR3 and GluR4 receptors. In a functional in vitro assay, no difference in potency was observed between GluR2(Q)(o) and GluR3(o) receptors. The thermodynamics of binding of the antagonists (S)-NS1209, DNQX and (S)-ATPO to the GluR2 ligand-binding core have been determined by displacement isothermal titration calorimetry. The displacement of (S)-glutamate by all antagonists was shown to be driven by enthalpy.

	~~{{STRUCTURE_2cmo\| PDB=2cmo \| SCENE= }}~~		The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.,Kasper C, Pickering DS, Mirza O, Olsen L, Kristensen AS, Greenwood JR, Liljefors T, Schousboe A, Watjen F, Gajhede M, Sigurskjold BW, Kastrup JS J Mol Biol. 2006 Apr 7;357(4):1184-201. Epub 2006 Jan 31. PMID:16483599<ref>PMID:16483599</ref>

	~~===THE STRUCTURE OF A MIXED GLUR2 LIGAND-BINDING CORE DIMER IN COMPLEX WITH (S)-GLUTAMATE AND THE ANTAGONIST (S)-NS1209===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16483599}}~~

	~~==About this Structure==~~
	~~[[2cmo]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2CMO OCA].~~

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016483599<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Gajhede, M.]]		[[Category: Gajhede, M.]]

OCA at 06:43, 20 October 2012

2012-10-20T06:43:04Z

← Older revision		Revision as of 06:43, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2cmo]] is a 2 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA].		[[2cmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA].

	==See Also==		==See Also==

OCA: Protected "2cmo" [edit=sysop:move=sysop]

2012-07-25T14:05:03Z

Protected "2cmo" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:05, 25 July 2012
(No difference)