2cpg - Revision history

OCA at 10:26, 6 September 2023

2023-09-06T10:26:52Z

← Older revision		Revision as of 10:26, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='2cpg' size='340' side='right'caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cpg' size='340' side='right'caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1b01\|1b01]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [https://pdbe.org/2cpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [https://www.ebi.ac.uk/pdbsum/2cpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [https://pdbe.org/2cpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [https://www.ebi.ac.uk/pdbsum/2cpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/COPG_STRAG COPG_STRAG]] Regulates the plasmid copy number. Binds to the RepAB promoter thus controlling the synthesis of the plasmid replication initiator protein RepB.<ref>PMID:2497439</ref> <ref>PMID:2373704</ref>		[https://www.uniprot.org/uniprot/COPG_STRAG COPG_STRAG] Regulates the plasmid copy number. Binds to the RepAB promoter thus controlling the synthesis of the plasmid replication initiator protein RepB.<ref>PMID:2497439</ref> <ref>PMID:2373704</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Streptoccocus de la mammite nocard and mollereau 1887]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Acebo, P]]		[[Category: Streptococcus agalactiae]]
	[[Category: Coll, M]]		[[Category: Acebo P]]
	[[Category: Eritja, R]]		[[Category: Coll M]]
	[[Category: Espinosa, M]]		[[Category: Eritja R]]
	[[Category: Gomis-Rueth~~, F X~~]]		[[Category: Espinosa M]]
	[[Category: Gonzalez, A]]		[[Category: Gomis-Rueth FX]]
	[[Category: Guasch, A]]		[[Category: Gonzalez A]]
	[[Category: Parraga, A]]		[[Category: Guasch A]]
	[[Category: Sola, M]]		[[Category: Parraga A]]
	[[Category: Solar, G ~~del]]~~		[[Category: Sola M]]
	~~[[Category: Dna-binding protein]]~~		[[Category: Del Solar G]]
	~~[[Category: Gene regulation]]~~
	~~[[Category: Plasmid]]~~
	~~[[Category: Transcriptional repressor~~]]

OCA at 06:59, 1 December 2021

2021-12-01T06:59:44Z

← Older revision		Revision as of 06:59, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2cpg' size='340' side='right'caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cpg' size='340' side='right'caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b01\|1b01]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [~~http~~://pdbe.org/2cpg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cpg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [https://pdbe.org/2cpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [https://www.ebi.ac.uk/pdbsum/2cpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/COPG_STRAG COPG_STRAG]] Regulates the plasmid copy number. Binds to the RepAB promoter thus controlling the synthesis of the plasmid replication initiator protein RepB.<ref>PMID:2497439</ref> <ref>PMID:2373704</ref>		[[https://www.uniprot.org/uniprot/COPG_STRAG COPG_STRAG]] Regulates the plasmid copy number. Binds to the RepAB promoter thus controlling the synthesis of the plasmid replication initiator protein RepB.<ref>PMID:2497439</ref> <ref>PMID:2373704</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:49, 26 February 2020

2020-02-26T10:49:54Z

← Older revision		Revision as of 10:49, 26 February 2020
Line 1:		Line 1:

	==TRANSCRIPTIONAL REPRESSOR COPG==		==TRANSCRIPTIONAL REPRESSOR COPG==
	<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cpg' size='340' side='right'caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Streptoccocus de la mammite nocard and mollereau 1887]]		[[Category: Streptoccocus de la mammite nocard and mollereau 1887]]
			[[Category: Large Structures]]
	[[Category: Acebo, P]]		[[Category: Acebo, P]]
	[[Category: Coll, M]]		[[Category: Coll, M]]

OCA at 08:06, 23 May 2018

2018-05-23T08:06:38Z

← Older revision		Revision as of 08:06, 23 May 2018
Line 1:		Line 1:

	==TRANSCRIPTIONAL REPRESSOR COPG==		==TRANSCRIPTIONAL REPRESSOR COPG==
	<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://pdbe.org/2cpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://pdbe.org/2cpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 36:
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
			[[Category: Plasmid]]
	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]

OCA at 17:25, 11 September 2015

2015-09-11T17:25:29Z

← Older revision		Revision as of 17:25, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_agalactiae Streptococcus agalactiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://pdbe.org/2cpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cpg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Streptococcus agalactiae~~]]		[[Category: Streptoccocus de la mammite nocard and mollereau 1887]]
	[[Category: Acebo, P]]		[[Category: Acebo, P]]
	[[Category: Coll, M]]		[[Category: Coll, M]]

OCA at 19:35, 25 December 2014

2014-12-25T19:35:34Z

← Older revision		Revision as of 19:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/COPG_STRAG COPG_STRAG]] Regulates the plasmid copy number. Binds to the RepAB promoter thus controlling the synthesis of the plasmid replication initiator protein RepB.<ref>PMID:2497439</ref> <ref>PMID:2373704</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus agalactiae]]		[[Category: Streptococcus agalactiae]]
	[[Category: Acebo, P.]]		[[Category: Acebo, P]]
	[[Category: Coll, M.]]		[[Category: Coll, M]]
	[[Category: Eritja, R.]]		[[Category: Eritja, R]]
	[[Category: Espinosa, M.]]		[[Category: Espinosa, M]]
	[[Category: Gomis-Rueth, F X.]]		[[Category: Gomis-Rueth, F X]]
	[[Category: Gonzalez, A.]]		[[Category: Gonzalez, A]]
	[[Category: Guasch, A.]]		[[Category: Guasch, A]]
	[[Category: Parraga, A.]]		[[Category: Parraga, A]]
	[[Category: Sola, M.]]		[[Category: Sola, M]]
	[[Category: Solar, G del.]]		[[Category: Solar, G del]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]

OCA at 06:51, 9 June 2014

2014-06-09T06:51:16Z

← Older revision		Revision as of 06:51, 9 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~2cpg~~.~~png~~\|~~left~~\|~~200px~~]]		==TRANSCRIPTIONAL REPRESSOR COPG==
			<StructureSection load='2cpg' size='340' side='right' caption='[[2cpg]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPG FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b01\|1b01]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpg RCSB], [http://www.ebi.ac.uk/pdbsum/2cpg PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The structure of the 45 amino acid transcriptional repressor, CopG, has been solved unliganded and bound to its target operator DNA. The protein, encoded by the promiscuous streptococcal plasmid pMV158, is involved in the control of plasmid copy number. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. It is the prototype for a family of homologous plasmid repressors. CopG cooperatively associates, completely protecting several turns on one face of the double helix in both directions from a 13-bp pseudosymmetric primary DNA recognition element. In the complex structure, one protein tetramer binds at one face of a 19-bp oligonucleotide, containing the pseudosymmetric element, with two beta-ribbons inserted into the major groove. The DNA is bent 60 degrees by compression of both major and minor grooves. The protein dimer displays topological similarity to Arc and MetJ repressors. Nevertheless, the functional tetramer has a unique structure with the two vicinal recognition ribbon elements at a short distance, thus inducing strong DNA bend. Further structural resemblance is found with helix-turn-helix regions of unrelated DNA-binding proteins. In contrast to these, however, the bihelical region of CopG has a role in oligomerization instead of DNA recognition. This observation unveils an evolutionary link between ribbon-helix-helix and helix-turn-helix proteins.

	~~{{STRUCTURE_2cpg\| PDB=2cpg \| SCENE= }}~~		The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator.,Gomis-Ruth FX, Sola M, Acebo P, Parraga A, Guasch A, Eritja R, Gonzalez A, Espinosa M, del Solar G, Coll M EMBO J. 1998 Dec 15;17(24):7404-15. PMID:9857196<ref>PMID:9857196</ref>

	~~===TRANSCRIPTIONAL REPRESSOR COPG===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9857196}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cpg]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:009857196<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Streptococcus agalactiae]]		[[Category: Streptococcus agalactiae]]
	[[Category: Acebo, P.]]		[[Category: Acebo, P.]]

OCA: Protected "2cpg" [edit=sysop:move=sysop]

2012-08-14T17:35:29Z

Protected "2cpg" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:35, 14 August 2012
(No difference)

OCA at 17:35, 14 August 2012

2012-08-14T17:35:27Z

← Older revision		Revision as of 17:35, 14 August 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2cpg.png\|left\|200px]]		[[Image:2cpg.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cpg", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cpg\| PDB=2cpg \| SCENE= }}		{{STRUCTURE_2cpg\| PDB=2cpg \| SCENE= }}

	===TRANSCRIPTIONAL REPRESSOR COPG===		===TRANSCRIPTIONAL REPRESSOR COPG===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9857196}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 9857196 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_9857196}}		{{ABSTRACT_PUBMED_9857196}}

	==About this Structure==		==About this Structure==
	~~2CPG is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA].		[[2cpg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPG OCA].

	==Reference==		==Reference==
	The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator., Gomis-Ruth FX, Sola M, Acebo P, Parraga A, Guasch A, Eritja R, Gonzalez A, Espinosa M, del Solar G, Coll M, EMBO J. 1998 Dec 15;17(24):7404-15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9857196 9857196]~~		<ref group="xtra">PMID:009857196</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Streptococcus agalactiae]]		[[Category: Streptococcus agalactiae]]
	[[Category: Acebo, P.]]		[[Category: Acebo, P.]]
Line 37:		Line 24:
	[[Category: Solar, G del.]]		[[Category: Solar, G del.]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: ~~Plasmid~~]]		[[Category: Gene regulation]]
	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:29:12 2008''~~

OCA at 08:29, 29 July 2008

2008-07-29T08:29:19Z

← Older revision		Revision as of 08:29, 29 July 2008
Line 1:		Line 1:
	[[Image:2cpg.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2cpg.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2cpg\| PDB=2cpg \| SCENE= }}		{{STRUCTURE_2cpg\| PDB=2cpg \| SCENE= }}

	~~'''~~TRANSCRIPTIONAL REPRESSOR COPG~~'''~~		===TRANSCRIPTIONAL REPRESSOR COPG===


	~~==Overview==~~		<!--
	The ~~structure of the 45 amino acid transcriptional repressor, CopG, has been solved unliganded and bound to its target operator DNA. The protein~~, ~~encoded by the promiscuous streptococcal plasmid pMV158~~, ~~is involved in~~ the ~~control of plasmid copy number. The structure of this protein repressor, which is the shortest reported~~ to ~~date and~~ the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. It is the prototype for a family of homologous plasmid repressors. CopG cooperatively associates, completely protecting several turns on ~~one face of the double helix in both directions from a 13-bp pseudosymmetric primary DNA recognition element. In the complex structure, one protein tetramer binds~~ at ~~one face of a 19-bp oligonucleotide, containing the pseudosymmetric element, with two beta-ribbons inserted into the major groove~~. ~~The DNA is bent 60 degrees by compression of both major and minor grooves. The protein dimer displays topological similarity to Arc and MetJ repressors~~. ~~Nevertheless, the functional tetramer has a unique structure with the two vicinal recognition ribbon elements at a short distance~~, ~~thus inducing strong DNA bend. Further structural resemblance~~ is ~~found with helix-turn-helix regions of unrelated DNA-binding proteins. In contrast to these, however,~~ the ~~bihelical region of CopG has a role in oligomerization instead of DNA recognition~~. ~~This observation unveils an evolutionary link between ribbon~~-~~helix~~-~~helix and helix-turn-helix proteins.~~		The line below this paragraph, {{ABSTRACT_PUBMED_9857196}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 9857196 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_9857196}}

	==About this Structure==		==About this Structure==
Line 35:		Line 39:
	[[Category: Plasmid]]		[[Category: Plasmid]]
	[[Category: Transcriptional repressor]]		[[Category: Transcriptional repressor]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 22~~:44:10 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:29:12 2008''