2cpr - Revision history

OCA at 11:28, 22 May 2024

2024-05-22T11:28:31Z

← Older revision		Revision as of 11:28, 22 May 2024
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	==Solution structure of the HRDC domain of human Exosome component 10==		==Solution structure of the HRDC domain of human Exosome component 10==
	<StructureSection load='2cpr' size='340' side='right'caption='[[2cpr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2cpr' size='340' side='right'caption='[[2cpr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>EXOSC10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [https://pdbe.org/2cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [https://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [https://pdbe.org/2cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [https://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN]] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref>		[https://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Muto, Y]]		[[Category: Muto Y]]
	[[Category: Nagata, T]]		[[Category: Nagata T]]
	~~[[Category: Structural genomic~~]]		[[Category: Shirouzu M]]
	[[Category: Shirouzu, M]]		[[Category: Terada T]]
	[[Category: Terada, T]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Gene regulation]]~~
	~~[[Category: Helix-bundle]]~~
	~~[[Category: Hrdc]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi~~]]

OCA at 11:45, 3 February 2021

2021-02-03T11:45:58Z

← Older revision		Revision as of 11:45, 3 February 2021
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	==Solution structure of the HRDC domain of human Exosome component 10==		==Solution structure of the HRDC domain of human Exosome component 10==
	<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cpr' size='340' side='right'caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [~~http~~://pdbe.org/2cpr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [https://pdbe.org/2cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [https://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN]] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref>		[[https://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN]] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Exosome\|Exosome]]		*[[Exosome 3D structures\|Exosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 08:11, 23 May 2018

2018-05-23T08:11:21Z

← Older revision		Revision as of 08:11, 23 May 2018
Line 1:		Line 1:

	==Solution structure of the HRDC domain of human Exosome component 10==		==Solution structure of the HRDC domain of human Exosome component 10==
	<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://pdbe.org/2cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://pdbe.org/2cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpr ProSAT], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpr_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:41, 9 February 2016

2016-02-09T16:41:46Z

← Older revision		Revision as of 16:41, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cpr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 00:10, 11 September 2015

2015-09-11T00:10:04Z

← Older revision		Revision as of 00:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://pdbe.org/2cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

			==See Also==
			*[[Exosome\|Exosome]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 08:08, 25 December 2014

2014-12-25T08:08:02Z

← Older revision		Revision as of 08:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/EXOSX_HUMAN EXOSX_HUMAN]] Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.<ref>PMID:14527413</ref> <ref>PMID:16455498</ref> <ref>PMID:17412707</ref> <ref>PMID:17545563</ref> <ref>PMID:18172165</ref> <ref>PMID:19056938</ref> <ref>PMID:20699273</ref> <ref>PMID:20368444</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Muto, Y.]]		[[Category: Muto, Y]]
	[[Category: Nagata, T.]]		[[Category: Nagata, T]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Shirouzu, M.]]		[[Category: Shirouzu, M]]
	[[Category: Terada, T.]]		[[Category: Terada, T]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Helix-bundle]]		[[Category: Helix-bundle]]
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	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~

OCA at 01:43, 30 September 2014

2014-09-30T01:43:37Z

← Older revision		Revision as of 01:43, 30 September 2014
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	~~[[Image:2cpr.png\|left\|200px]]~~		==Solution structure of the HRDC domain of human Exosome component 10==
			<StructureSection load='2cpr' size='340' side='right' caption='[[2cpr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{STRUCTURE_2cpr\| PDB=2cpr \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPR FirstGlance]. <br>
	===Solution structure of the HRDC domain of human Exosome component 10===		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EXOSC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpr RCSB], [http://www.ebi.ac.uk/pdbsum/2cpr PDBsum], [http://www.topsan.org/Proteins/RSGI/2cpr TOPSAN]</span></td></tr>
			<table>
	==~~About this Structure~~==		== Evolutionary Conservation ==
	[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA].		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpr_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "2cpr" [edit=sysop:move=sysop]

2013-01-06T10:58:27Z

Protected "2cpr" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:58, 6 January 2013
(No difference)

OCA at 10:58, 6 January 2013

2013-01-06T10:58:19Z

← Older revision		Revision as of 10:58, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2cpr.png\|left\|200px]]		[[Image:2cpr.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cpr", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cpr\| PDB=2cpr \| SCENE= }}		{{STRUCTURE_2cpr\| PDB=2cpr \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2CPR~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA].		[[2cpr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
Line 24:		Line 17:
	[[Category: Terada, T.]]		[[Category: Terada, T.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
			[[Category: Gene regulation]]
	[[Category: Helix-bundle]]		[[Category: Helix-bundle]]
	[[Category: Hrdc]]		[[Category: Hrdc]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:09:29 2008''~~

OCA at 10:09, 16 November 2008

2008-11-16T10:09:29Z

← Older revision		Revision as of 10:09, 16 November 2008
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	==About this Structure==		==About this Structure==
	2CPR is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA].		2CPR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPR OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28 18~~:47:50 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:09:29 2008''