2cqa - Revision history

OCA at 11:28, 22 May 2024

2024-05-22T11:28:50Z

← Older revision		Revision as of 11:28, 22 May 2024
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	==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==		==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==
	<StructureSection load='2cqa' size='340' side='right'caption='[[2cqa~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2cqa' size='340' side='right'caption='[[2cqa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>RUVBL2, TIP48, TIP49B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [https://pdbe.org/2cqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [https://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqa ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [https://pdbe.org/2cqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [https://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqa ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/RUVB2_HUMAN RUVB2_HUMAN]] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.<ref>PMID:14966270</ref>		[https://www.uniprot.org/uniprot/RUVB2_HUMAN RUVB2_HUMAN] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.<ref>PMID:14966270</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Abe, T]]		[[Category: Abe T]]
	[[Category: Hirota, H]]		[[Category: Hirota H]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	~~[[Category: Structural genomic~~]]		[[Category: Saito K]]
	[[Category: Saito, K]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Ecp-51]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Reptin 52]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Ruvb like 2]]~~
	~~[[Category: Tap54-beta]]~~
	~~[[Category: Tip48]]~~
	~~[[Category: Tip49b~~]]

OCA at 06:20, 9 March 2022

2022-03-09T06:20:03Z

← Older revision		Revision as of 06:20, 9 March 2022
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	==See Also==		==See Also==
	*[[AGR2\|AGR2]]
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==

OCA at 11:46, 3 February 2021

2021-02-03T11:46:30Z

← Older revision		Revision as of 11:46, 3 February 2021
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	==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==		==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==
	<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cqa' size='340' side='right'caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [~~http~~://pdbe.org/2cqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqa ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [https://pdbe.org/2cqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [https://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqa ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RUVB2_HUMAN RUVB2_HUMAN]] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.<ref>PMID:14966270</ref>		[[https://www.uniprot.org/uniprot/RUVB2_HUMAN RUVB2_HUMAN]] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.<ref>PMID:14966270</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqa ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

			==See Also==
			*[[AGR2\|AGR2]]
			*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Abe, T]]		[[Category: Abe, T]]
	[[Category: Hirota, H]]		[[Category: Hirota, H]]

OCA at 08:42, 23 May 2018

2018-05-23T08:42:28Z

← Older revision		Revision as of 08:42, 23 May 2018
Line 1:		Line 1:

	==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==		==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==
	<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://pdbe.org/2cqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://pdbe.org/2cqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqa ProSAT], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqa_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:15, 9 February 2016

2016-02-09T12:15:08Z

← Older revision		Revision as of 12:15, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 22:09, 10 September 2015

2015-09-10T22:09:21Z

← Older revision		Revision as of 22:09, 10 September 2015
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	<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://pdbe.org/2cqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Abe, T]]		[[Category: Abe, T]]
	[[Category: Hirota, H]]		[[Category: Hirota, H]]

OCA at 06:45, 25 December 2014

2014-12-25T06:45:10Z

← Older revision		Revision as of 06:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RUVB2_HUMAN RUVB2_HUMAN]] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.<ref>PMID:14966270</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abe, T.]]		[[Category: Abe, T]]
	[[Category: Hirota, H.]]		[[Category: Hirota, H]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Saito, K.]]		[[Category: Saito, K]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Ecp-51]]		[[Category: Ecp-51]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 31:		Line 35:
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Reptin 52]]		[[Category: Reptin 52]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Ruvb like 2]]		[[Category: Ruvb like 2]]
	~~[[Category: Structural genomic]]~~
	[[Category: Tap54-beta]]		[[Category: Tap54-beta]]
	[[Category: Tip48]]		[[Category: Tip48]]
	[[Category: Tip49b]]		[[Category: Tip49b]]

OCA at 03:02, 30 September 2014

2014-09-30T03:02:12Z

← Older revision		Revision as of 03:02, 30 September 2014
Line 1:		Line 1:
	~~[[Image:2cqa.png\|left\|200px]]~~		==Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA==
			<StructureSection load='2cqa' size='340' side='right' caption='[[2cqa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{STRUCTURE_2cqa\| PDB=2cqa \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CQA FirstGlance]. <br>
	===Solution structure of RSGI RUH-039, a fragment of C-terminal domain of RuvB-like 2 from human cDNA===		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RUVBL2, TIP48, TIP49B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cqa RCSB], [http://www.ebi.ac.uk/pdbsum/2cqa PDBsum], [http://www.topsan.org/Proteins/RSGI/2cqa TOPSAN]</span></td></tr>
			<table>
	==~~About this Structure~~==		== Evolutionary Conservation ==
	[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA].		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqa_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abe, T.]]		[[Category: Abe, T.]]

OCA: Protected "2cqa" [edit=sysop:move=sysop]

2013-01-06T12:12:12Z

Protected "2cqa" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:12, 6 January 2013
(No difference)

OCA at 12:12, 6 January 2013

2013-01-06T12:12:08Z

← Older revision		Revision as of 12:12, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2cqa.png\|left\|200px]]		[[Image:2cqa.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cqa", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cqa\| PDB=2cqa \| SCENE= }}		{{STRUCTURE_2cqa\| PDB=2cqa \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2CQA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA].		[[2cqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQA OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abe, T.]]		[[Category: Abe, T.]]
Line 24:		Line 17:
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
	[[Category: Ecp-51]]		[[Category: Ecp-51]]
			[[Category: Hydrolase]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
Line 34:		Line 28:
	[[Category: Tip48]]		[[Category: Tip48]]
	[[Category: Tip49b]]		[[Category: Tip49b]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:47:17 2008''~~