2csa - Revision history

OCA at 16:33, 13 December 2023

2023-12-13T16:33:45Z

← Older revision		Revision as of 16:33, 13 December 2023
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	==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==		==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
	<StructureSection load='2csa' size='340' side='right'caption='[[2csa~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2csa' size='340' side='right'caption='[[2csa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [https://pdbe.org/2csa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [https://www.ebi.ac.uk/pdbsum/2csa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [https://pdbe.org/2csa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [https://www.ebi.ac.uk/pdbsum/2csa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>		[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.		[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fox, D]]		[[Category: Fox D]]
	[[Category: Iverson~~, H A~~]]		[[Category: Iverson HA]]
	[[Category: Klevit~~, R E~~]]		[[Category: Klevit RE]]
	[[Category: Nadler~~, L S~~]]		[[Category: Nadler LS]]
	[[Category: Nathanson~~, N M]]~~		[[Category: Nathanson NM]]
	~~[[Category: Basolateral sorting-signal blss beta-turn]]~~
	~~[[Category: Signaling protein-membrane protein complex~~]]

OCA at 07:00, 1 December 2021

2021-12-01T07:00:18Z

← Older revision		Revision as of 07:00, 1 December 2021
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	<StructureSection load='2csa' size='340' side='right'caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2csa' size='340' side='right'caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [~~http~~://pdbe.org/2csa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2csa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [https://pdbe.org/2csa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [https://www.ebi.ac.uk/pdbsum/2csa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[~~http~~://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>		[[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.		[[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:46, 26 February 2020

2020-02-26T10:46:23Z

← Older revision		Revision as of 10:46, 26 February 2020
Line 1:		Line 1:

	==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==		==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
	<StructureSection load='2csa' size='340' side='right' caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2csa' size='340' side='right'caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Fox, D]]		[[Category: Fox, D]]
	[[Category: Iverson, H A]]		[[Category: Iverson, H A]]

OCA at 08:01, 23 May 2018

2018-05-23T08:01:39Z

← Older revision		Revision as of 08:01, 23 May 2018
Line 1:		Line 1:

	==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==		==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
	<StructureSection load='2csa' size='340' side='right' caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2csa' size='340' side='right' caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://pdbe.org/2csa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://pdbe.org/2csa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:40, 10 September 2015

2015-09-10T20:40:58Z

← Older revision		Revision as of 20:40, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://pdbe.org/2csa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2csa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:33, 18 December 2014

2014-12-18T11:33:07Z

← Older revision		Revision as of 11:33, 18 December 2014
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	~~{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}~~		==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
	===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===		<StructureSection load='2csa' size='340' side='right' caption='[[2csa]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_15870063}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
	==Disease==		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum]</span></td></tr>
	[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[http://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>		</table>
			== Disease ==
	==Function==		[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[http://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.		[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Muscarinic acetylcholine receptors comprise a family of G-protein-coupled receptors that display differential localization in polarized epithelial cells. We identify a seven-residue sequence, Ala(275)-Val(281), in the third intracellular loop of the M(3) muscarinic receptor that mediates dominant, position-independent basolateral targeting in Madin-Darby canine kidney cells. Mutational analyses identify Glu(276), Phe(280), and Val(281) as critical residues within this sorting motif. Phe(280) and Val(281) comprise a novel dihydrophobic sorting signal as mutations of either residue singly or together with leucine do not disrupt basolateral targeting. Conversely, Glu(276) is required and cannot be substituted with alanine or aspartic acid. A 19-amino acid peptide representing the M(3) sorting signal and surrounding sequence was analyzed via two-dimensional nuclear magnetic resonance spectroscopy. Solution structures show that Glu(276) resides in a type IV beta-turn and the dihydrophobic sequence Phe(280)Val(281) adopts either a type I or IV beta-turn.

	~~==About this Structure==~~		Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.,Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. PMID:15870063<ref>PMID:15870063</ref>
	~~[[2csa]] is a~~ 1 ~~chain structure. Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2CSA OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	<references ~~group="xtra"~~/><~~references~~/>		</div>
	[[Category: Fox, D.]]		== References ==
	[[Category: Iverson, H A.]]		<references/>
	[[Category: Klevit, R E.]]		__TOC__
	[[Category: Nadler, L S.]]		</StructureSection>
	[[Category: Nathanson, N M.]]		[[Category: Fox, D]]
			[[Category: Iverson, H A]]
			[[Category: Klevit, R E]]
			[[Category: Nadler, L S]]
			[[Category: Nathanson, N M]]
	[[Category: Basolateral sorting-signal blss beta-turn]]		[[Category: Basolateral sorting-signal blss beta-turn]]
	[[Category: Signaling protein-membrane protein complex]]		[[Category: Signaling protein-membrane protein complex]]

OCA at 05:25, 25 March 2013

2013-03-25T05:25:38Z

← Older revision		Revision as of 05:25, 25 March 2013
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	~~[[Image:2csa.png\|left\|200px]]~~

	{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}		{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}
			===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===
			{{ABSTRACT_PUBMED_15870063}}

	===~~Structure~~ of ~~the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===~~		==Disease==
			[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[http://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>

	~~{{ABSTRACT_PUBMED_15870063}}~~		==Function==
			[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

	==About this Structure==		==About this Structure==
	[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].		[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Fox, D.]]		[[Category: Fox, D.]]
	[[Category: Iverson, H A.]]		[[Category: Iverson, H A.]]

OCA: Protected "2csa" [edit=sysop:move=sysop]

2013-01-06T10:49:36Z

Protected "2csa" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:49, 6 January 2013
(No difference)

OCA at 10:49, 6 January 2013

2013-01-06T10:49:34Z

← Older revision		Revision as of 10:49, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2csa.png\|left\|200px]]		[[Image:2csa.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2csa", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}		{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}

	===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===		===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_15870063}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 15870063 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_15870063}}		{{ABSTRACT_PUBMED_15870063}}

	==About this Structure==		==About this Structure==
	~~2CSA is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].		[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].

	~~==Reference==~~
	Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal., Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM, J Biol Chem. 2005 Jul 1;280(26):24568-75. Epub 2005 May 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15870063 15870063]
	~~[[Category: Single protein]]~~
	[[Category: Fox, D.]]		[[Category: Fox, D.]]
	[[Category: Iverson, H A.]]		[[Category: Iverson, H A.]]
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	[[Category: Nathanson, N M.]]		[[Category: Nathanson, N M.]]
	[[Category: Basolateral sorting-signal blss beta-turn]]		[[Category: Basolateral sorting-signal blss beta-turn]]
			[[Category: Signaling protein-membrane protein complex]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 12:00:03 2008''~~

OCA at 09:00, 28 July 2008

2008-07-28T09:00:05Z

← Older revision		Revision as of 09:00, 28 July 2008
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	[[Image:2csa.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2csa.png\|left\|200px]]

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	{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}		{{STRUCTURE_2csa\| PDB=2csa \| SCENE= }}

	~~'''~~Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal~~'''~~		===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal===


	~~==Overview==~~		<!--
	~~Muscarinic acetylcholine receptors comprise a family of G~~-~~protein~~-~~coupled receptors that display differential localization in polarized epithelial cells. We identify a seven-residue sequence~~, ~~Ala(275)-Val(281)~~, in the ~~third intracellular loop of~~ the M(~~3) muscarinic receptor that mediates dominant, position-independent basolateral targeting in Madin-Darby canine kidney cells~~. ~~Mutational analyses identify Glu(276), Phe(280), and Val(281) as critical residues within this sorting motif~~. ~~Phe(280) and Val(281~~) ~~comprise a novel dihydrophobic sorting signal as mutations of either residue singly or together with leucine do not disrupt basolateral targeting. Conversely~~, ~~Glu(276)~~ is ~~required and cannot be substituted with alanine or aspartic acid. A 19-amino acid peptide representing~~ the ~~M(3) sorting signal and surrounding sequence was analyzed via two-dimensional nuclear magnetic resonance spectroscopy~~. ~~Solution structures show that Glu(276) resides in a type IV beta~~-~~turn and the dihydrophobic sequence Phe(280)Val(281) adopts either a type I or IV beta~~-~~turn.~~		The line below this paragraph, {{ABSTRACT_PUBMED_15870063}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 15870063 is the PubMed ID number.
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			{{ABSTRACT_PUBMED_15870063}}

	==About this Structure==		==About this Structure==
	2CSA is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].		2CSA is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA].

	==Reference==		==Reference==
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	[[Category: Nathanson, N M.]]		[[Category: Nathanson, N M.]]
	[[Category: Basolateral sorting-signal blss beta-turn]]		[[Category: Basolateral sorting-signal blss beta-turn]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 22~~:56:20 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:00:03 2008''