2csf - Revision history

OCA at 11:30, 22 May 2024

2024-05-22T11:30:07Z

← Older revision		Revision as of 11:30, 22 May 2024
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	==Solution structure of the second CUT domain of human SATB2==		==Solution structure of the second CUT domain of human SATB2==
	<StructureSection load='2csf' size='340' side='right'caption='[[2csf~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2csf' size='340' side='right'caption='[[2csf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>KAZUSA cDNA fh00753 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [https://pdbe.org/2csf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [https://www.ebi.ac.uk/pdbsum/2csf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csf ProSAT], [https://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [https://pdbe.org/2csf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [https://www.ebi.ac.uk/pdbsum/2csf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csf ProSAT], [https://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).		[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>		[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi F]]
	[[Category: Inoue, K]]		[[Category: Inoue K]]
	~~[[Category: Structural genomic~~]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Cut domain]]~~
	~~[[Category: Dna-binding protein satb2]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Special at-rich sequence-binding protein 2]]~~
	~~[[Category: Transcription~~]]

OCA at 11:49, 3 February 2021

2021-02-03T11:49:06Z

← Older revision		Revision as of 11:49, 3 February 2021
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	==Solution structure of the second CUT domain of human SATB2==		==Solution structure of the second CUT domain of human SATB2==
	<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2csf' size='340' side='right'caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [~~http~~://pdbe.org/2csf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2csf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2csf ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [https://pdbe.org/2csf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [https://www.ebi.ac.uk/pdbsum/2csf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csf ProSAT], [https://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[~~http~~://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).		[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>		[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 08:32, 23 May 2018

2018-05-23T08:32:26Z

← Older revision		Revision as of 08:32, 23 May 2018
Line 1:		Line 1:

	==Solution structure of the second CUT domain of human SATB2==		==Solution structure of the second CUT domain of human SATB2==
	<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://pdbe.org/2csf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://pdbe.org/2csf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2csf ProSAT], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2csf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2csf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:31, 7 February 2016

2016-02-07T13:31:12Z

← Older revision		Revision as of 13:31, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2csf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 01:55, 10 September 2015

2015-09-10T01:55:38Z

← Older revision		Revision as of 01:55, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://pdbe.org/2csf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 18:17, 15 January 2015

2015-01-15T18:17:18Z

← Older revision		Revision as of 18:17, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).		[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K.]]		[[Category: Inoue, K]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Cut domain]]		[[Category: Cut domain]]
	[[Category: Dna-binding protein satb2]]		[[Category: Dna-binding protein satb2]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Special at-rich sequence-binding protein 2]]		[[Category: Special at-rich sequence-binding protein 2]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 01:13, 30 September 2014

2014-09-30T01:13:03Z

← Older revision		Revision as of 01:13, 30 September 2014
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	~~{{STRUCTURE_2csf\| PDB=2csf \| SCENE= }}~~		==Solution structure of the second CUT domain of human SATB2==
	===Solution structure of the second CUT domain of human SATB2===		<StructureSection load='2csf' size='340' side='right' caption='[[2csf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSF FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref><ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2csf RCSB], [http://www.ebi.ac.uk/pdbsum/2csf PDBsum], [http://www.topsan.org/Proteins/RSGI/2csf TOPSAN]</span></td></tr>
	==Function==		<table>
	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>		== Disease ==
			[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
	==~~About this Structure~~==		== Function ==
	[[~~2csf~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2CSF OCA~~].		[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
			== Evolutionary Conservation ==
	==~~Reference~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	<references ~~group="xtra"~~/><~~references~~/>		Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2csf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 20:01, 24 March 2013

2013-03-24T20:01:07Z

← Older revision		Revision as of 20:01, 24 March 2013
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	~~[[Image:2csf.png\|left\|200px]]~~

	{{STRUCTURE_2csf\| PDB=2csf \| SCENE= }}		{{STRUCTURE_2csf\| PDB=2csf \| SCENE= }}
			===Solution structure of the second CUT domain of human SATB2===

	===~~Solution structure~~ of the ~~second CUT domain~~ of ~~human SATB2===~~		==Disease==
			[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref><ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).

			==Function==
			[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>

	==About this Structure==		==About this Structure==
	[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA].		[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA: Protected "2csf" [edit=sysop:move=sysop]

2013-01-06T10:28:39Z

Protected "2csf" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:28, 6 January 2013
(No difference)

OCA at 10:28, 6 January 2013

2013-01-06T10:28:36Z

← Older revision		Revision as of 10:28, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2csf.png\|left\|200px]]		[[Image:2csf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2csf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2csf\| PDB=2csf \| SCENE= }}		{{STRUCTURE_2csf\| PDB=2csf \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2CSF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA].		[[2csf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSF OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
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	[[Category: Special at-rich sequence-binding protein 2]]		[[Category: Special at-rich sequence-binding protein 2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
			[[Category: Transcription]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun Nov 16 16:31:27 2008''~~