2css - Revision history

OCA at 11:30, 22 May 2024

2024-05-22T11:30:19Z

← Older revision		Revision as of 11:30, 22 May 2024
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	==Solution structure of the PDZ domain of human KIAA0340 protein==		==Solution structure of the PDZ domain of human KIAA0340 protein==
	<StructureSection load='2css' size='340' side='right'caption='[[2css~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2css' size='340' side='right'caption='[[2css]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>KAZUSA cDNA hg01396 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [https://pdbe.org/2css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [https://www.ebi.ac.uk/pdbsum/2css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [https://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [https://pdbe.org/2css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [https://www.ebi.ac.uk/pdbsum/2css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [https://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[https://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>		[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[https://omim.org/entry/603649 603649]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).		[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi F]]
	[[Category: Inoue, K]]		[[Category: Inoue K]]
	[[Category: Qin, X R]]		[[Category: Qin X-R]]
	~~[[Category: Structural genomic~~]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Endocytosis-exocytosis complex]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Pdz domain]]~~
	~~[[Category: Rab3-interacting molecule 1]]~~
	~~[[Category: Regulating synaptic membrane exocytosis protein 1]]~~
	~~[[Category: Rim 1]]~~
	~~[[Category: Rsgi~~]]

OCA at 11:49, 3 February 2021

2021-02-03T11:49:25Z

← Older revision		Revision as of 11:49, 3 February 2021
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	==Solution structure of the PDZ domain of human KIAA0340 protein==		==Solution structure of the PDZ domain of human KIAA0340 protein==
	<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2css' size='340' side='right'caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [~~http~~://pdbe.org/2css PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2css PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [https://pdbe.org/2css PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [https://www.ebi.ac.uk/pdbsum/2css PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [https://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[~~http~~://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>		[[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[https://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).		[[https://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 08:39, 23 May 2018

2018-05-23T08:39:27Z

← Older revision		Revision as of 08:39, 23 May 2018
Line 1:		Line 1:

	==Solution structure of the PDZ domain of human KIAA0340 protein==		==Solution structure of the PDZ domain of human KIAA0340 protein==
	<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://pdbe.org/2css PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://pdbe.org/2css PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2css ProSAT], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2css_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2css_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:11, 9 February 2016

2016-02-09T12:11:02Z

← Older revision		Revision as of 12:11, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2css ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 22:07, 10 September 2015

2015-09-10T22:07:17Z

← Older revision		Revision as of 22:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://pdbe.org/2css PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 18:28, 15 January 2015

2015-01-15T18:28:45Z

← Older revision		Revision as of 18:28, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[http://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>		[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[http://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K.]]		[[Category: Inoue, K]]
	[[Category: Qin, X R.]]		[[Category: Qin, X R]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Endocytosis-exocytosis complex]]		[[Category: Endocytosis-exocytosis complex]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
Line 36:		Line 36:
	[[Category: Rab3-interacting molecule 1]]		[[Category: Rab3-interacting molecule 1]]
	[[Category: Regulating synaptic membrane exocytosis protein 1]]		[[Category: Regulating synaptic membrane exocytosis protein 1]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rim 1]]		[[Category: Rim 1]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~

OCA at 03:00, 30 September 2014

2014-09-30T03:00:10Z

← Older revision		Revision as of 03:00, 30 September 2014
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	~~{{STRUCTURE_2css\| PDB=2css \| SCENE= }}~~		==Solution structure of the PDZ domain of human KIAA0340 protein==
	===Solution structure of the PDZ domain of human KIAA0340 protein===		<StructureSection load='2css' size='340' side='right' caption='[[2css]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSS FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[http://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hg01396 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2css FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2css OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2css RCSB], [http://www.ebi.ac.uk/pdbsum/2css PDBsum], [http://www.topsan.org/Proteins/RSGI/2css TOPSAN]</span></td></tr>
	==Function==		<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[http://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).		[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).
			== Evolutionary Conservation ==
	==~~About this Structure~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	[[~~2css~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2CSS OCA~~].		Check<jmol>
			<jmolCheckbox>
	==~~Reference~~==		<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2css_consurf.spt"</scriptWhenChecked>
	<references ~~group="xtra"~~/><~~references~~/>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 07:13, 25 March 2013

2013-03-25T07:13:35Z

← Older revision		Revision as of 07:13, 25 March 2013
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	~~[[Image:2css.png\|left\|200px]]~~

	{{STRUCTURE_2css\| PDB=2css \| SCENE= }}		{{STRUCTURE_2css\| PDB=2css \| SCENE= }}
			===Solution structure of the PDZ domain of human KIAA0340 protein===

	===~~Solution structure~~ of the ~~PDZ domain~~ of ~~human KIAA0340 protein===~~		==Disease==
			[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:[http://omim.org/entry/603649 603649]]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.<ref>PMID:12659814</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/RIMS1_HUMAN RIMS1_HUMAN]] Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity).

	==About this Structure==		==About this Structure==
	[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA].		[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA: Protected "2css" [edit=sysop:move=sysop]

2013-01-06T12:10:07Z

Protected "2css" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:10, 6 January 2013
(No difference)

OCA at 12:10, 6 January 2013

2013-01-06T12:10:02Z

← Older revision		Revision as of 12:10, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2css.png\|left\|200px]]		[[Image:2css.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2css", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2css\| PDB=2css \| SCENE= }}		{{STRUCTURE_2css\| PDB=2css \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2CSS~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA].		[[2css]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSS OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
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	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]		[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
			[[Category: Endocytosis-exocytosis complex]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:44:40 2008''~~