2ct2 - Revision history

OCA at 11:30, 22 May 2024

2024-05-22T11:30:31Z

← Older revision		Revision as of 11:30, 22 May 2024
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	==Solution Structure of the RING domain of the Tripartite motif protein 32==		==Solution Structure of the RING domain of the Tripartite motif protein 32==
	<StructureSection load='2ct2' size='340' side='right'caption='[[2ct2~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2ct2' size='340' side='right'caption='[[2ct2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TRIM32 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [https://pdbe.org/2ct2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [https://pdbe.org/2ct2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[https://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[https://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>		[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[https://omim.org/entry/254110 254110]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[https://omim.org/entry/209900 209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>		[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	[[Category: Miyamoto, K]]		[[Category: Miyamoto K]]
	~~[[Category: Structural genomic~~]]		[[Category: Sato M]]
	[[Category: Sato, M]]		[[Category: Tochio N]]
	[[Category: Tochio, N]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Ligase]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Ring domain]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Tat-interacting protein]]~~
	~~[[Category: Tripartite motif protein 32]]~~
	~~[[Category: Zinc-finger protein ht2a~~]]

OCA at 11:49, 3 February 2021

2021-02-03T11:49:45Z

← Older revision		Revision as of 11:49, 3 February 2021
Line 1:		Line 1:

	==Solution Structure of the RING domain of the Tripartite motif protein 32==		==Solution Structure of the RING domain of the Tripartite motif protein 32==
	<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ct2' size='340' side='right'caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [~~http~~://pdbe.org/2ct2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct2 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [https://pdbe.org/2ct2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[~~http~~://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[~~http~~://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>		[[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[https://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[https://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>		[[https://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ct2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ct2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

			==See Also==
			*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 08:34, 23 May 2018

2018-05-23T08:34:13Z

← Older revision		Revision as of 08:34, 23 May 2018
Line 1:		Line 1:

	==Solution Structure of the RING domain of the Tripartite motif protein 32==		==Solution Structure of the RING domain of the Tripartite motif protein 32==
	<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://pdbe.org/2ct2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://pdbe.org/2ct2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct2 ProSAT], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ct2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ct2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:13, 9 February 2016

2016-02-09T19:13:04Z

← Older revision		Revision as of 19:13, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ct2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 01:14, 11 September 2015

2015-09-11T01:14:34Z

← Older revision		Revision as of 01:14, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://pdbe.org/2ct2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 18:19, 15 January 2015

2015-01-15T18:19:35Z

← Older revision		Revision as of 18:19, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[http://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[http://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>		[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[http://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[http://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: Miyamoto, K.]]		[[Category: Miyamoto, K]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Sato, M.]]		[[Category: Sato, M]]
	[[Category: Tochio, N.]]		[[Category: Tochio, N]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Ring domain]]		[[Category: Ring domain]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~
	[[Category: Tat-interacting protein]]		[[Category: Tat-interacting protein]]
	[[Category: Tripartite motif protein 32]]		[[Category: Tripartite motif protein 32]]
	[[Category: Zinc-finger protein ht2a]]		[[Category: Zinc-finger protein ht2a]]

OCA at 02:53, 30 September 2014

2014-09-30T02:53:27Z

← Older revision		Revision as of 02:53, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2ct2\| PDB=2ct2 \| SCENE= }}~~		==Solution Structure of the RING domain of the Tripartite motif protein 32==
	===Solution Structure of the RING domain of the Tripartite motif protein 32===		<StructureSection load='2ct2' size='340' side='right' caption='[[2ct2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CT2 FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[http://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref><ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[http://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIM32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	==Function==		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ct2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ct2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ct2 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ct2 TOPSAN]</span></td></tr>
	[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>		<table>
			== Disease ==
	==~~About this Structure~~==		[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[http://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref> <ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[http://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>
	[[~~2ct2~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2CT2 OCA~~].		== Function ==
			[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>
	==~~Reference~~==		== Evolutionary Conservation ==
	<references ~~group="xtra"~~/><~~references~~/>		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ct2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA at 17:44, 24 March 2013

2013-03-24T17:44:06Z

← Older revision		Revision as of 17:44, 24 March 2013
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	~~[[Image:2ct2.png\|left\|200px]]~~

	{{STRUCTURE_2ct2\| PDB=2ct2 \| SCENE= }}		{{STRUCTURE_2ct2\| PDB=2ct2 \| SCENE= }}
			===Solution Structure of the RING domain of the Tripartite motif protein 32===

	===~~Solution Structure~~ of the ~~RING domain~~ of the ~~Tripartite motif protein 32===~~		==Disease==
			[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H) [MIM:[http://omim.org/entry/254110 254110]]; also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.<ref>PMID:11822024</ref><ref>PMID:17994549</ref> Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11) [MIM:[http://omim.org/entry/209900 209900]]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.<ref>PMID:16606853</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/TRI32_HUMAN TRI32_HUMAN]] Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.<ref>PMID:19349376</ref>

	==About this Structure==		==About this Structure==
	[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA].		[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "2ct2" [edit=sysop:move=sysop]

2013-01-06T12:03:59Z

Protected "2ct2" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:03, 6 January 2013
(No difference)

OCA at 12:03, 6 January 2013

2013-01-06T12:03:58Z

← Older revision		Revision as of 12:03, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2ct2.png\|left\|200px]]		[[Image:2ct2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ct2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ct2\| PDB=2ct2 \| SCENE= }}		{{STRUCTURE_2ct2\| PDB=2ct2 \| SCENE= }}

	===Solution Structure of the RING domain of the Tripartite motif protein 32===		===Solution Structure of the RING domain of the Tripartite motif protein 32===


	~~==Disease==~~
	Known disease associated with this structure: Bardet-Biedl syndrome 11 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602290 602290]], Muscular dystrophy, limb-girdle, type 2H OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602290 602290]]

	==About this Structure==		==About this Structure==
	~~2CT2~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA].		[[2ct2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT2 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
Line 27:		Line 17:
	[[Category: Tochio, N.]]		[[Category: Tochio, N.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
			[[Category: Ligase]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
Line 36:		Line 27:
	[[Category: Tripartite motif protein 32]]		[[Category: Tripartite motif protein 32]]
	[[Category: Zinc-finger protein ht2a]]		[[Category: Zinc-finger protein ht2a]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 14:13:24 2008''~~