2ctx - Revision history

OCA at 09:04, 6 November 2024

2024-11-06T09:04:18Z

← Older revision		Revision as of 09:04, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctx_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:30, 22 May 2024

2024-05-22T11:30:58Z

← Older revision		Revision as of 11:30, 22 May 2024
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	<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Indian_cobra Indian cobra~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [https://pdbe.org/2ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [https://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [https://pdbe.org/2ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [https://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~NXL3_NAJNA NXL3_NAJNA]~~] ~~Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.~~ Binds to muscular and neuronal (~~only~~ alpha-7 ~~alpha-8 alpha-9~~) nicotinic acetylcholine ~~receptors~~ (~~By similarity~~).		[https://www.uniprot.org/uniprot/3L23_NAJNA 3L23_NAJNA] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Indian cobra]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Betzel, C]]		[[Category: Naja naja]]
	[[Category: Lange, G]]		[[Category: Betzel C]]
	[[Category: Maelicke, A]]		[[Category: Lange G]]
	[[Category: Pal~~, G P~~]]		[[Category: Maelicke A]]
	[[Category: Saenger, W]]		[[Category: Pal GP]]
	[[Category: Wilson~~, K S]]~~		[[Category: Saenger W]]
	~~[[Category: Neurotoxin~~]]		[[Category: Wilson KS]]

OCA at 20:37, 20 October 2021

2021-10-20T20:37:15Z

← Older revision		Revision as of 20:37, 20 October 2021
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	<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [~~http~~://pdbe.org/2ctx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [https://pdbe.org/2ctx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [https://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).		[[https://www.uniprot.org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:21, 11 December 2019

2019-12-11T19:21:26Z

← Older revision		Revision as of 19:21, 11 December 2019
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	==THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION==		==THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION==
	<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ctx' size='340' side='right'caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctx_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Indian cobra]]		[[Category: Indian cobra]]
			[[Category: Large Structures]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Lange, G]]		[[Category: Lange, G]]

OCA at 07:05, 29 November 2017

2017-11-29T07:05:47Z

← Older revision		Revision as of 07:05, 29 November 2017
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	==THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION==		==THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION==
	<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://pdbe.org/2ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://pdbe.org/2ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ctx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ctx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:33, 12 September 2015

2015-09-12T01:33:21Z

← Older revision		Revision as of 01:33, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Naja_naja Naja naja~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_cobra Indian cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://pdbe.org/2ctx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ctx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Naja naja~~]]		[[Category: Indian cobra]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]
	[[Category: Lange, G]]		[[Category: Lange, G]]

OCA at 22:02, 25 December 2014

2014-12-25T22:02:44Z

← Older revision		Revision as of 22:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Naja naja]]		[[Category: Naja naja]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C]]
	[[Category: Lange, G.]]		[[Category: Lange, G]]
	[[Category: Maelicke, A.]]		[[Category: Maelicke, A]]
	[[Category: Pal, G P.]]		[[Category: Pal, G P]]
	[[Category: Saenger, W.]]		[[Category: Saenger, W]]
	[[Category: Wilson, K S.]]		[[Category: Wilson, K S]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 11:11, 3 October 2014

2014-10-03T11:11:23Z

← Older revision		Revision as of 11:11, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2ctx\| PDB=2ctx \| SCENE= }}~~		==THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION==
	===THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION===		<StructureSection load='2ctx' size='340' side='right' caption='[[2ctx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	~~{{ABSTRACT_PUBMED_1939183}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ctx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CTX FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ctx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ctx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ctx RCSB], [http://www.ebi.ac.uk/pdbsum/2ctx PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/2ctx_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of the "long" alpha-neurotoxin alpha-cobratoxin was refined to an R-factor of 19.5% using 3271 x-ray data to 2.4-A resolution. The polypeptide chain forms three loops, I, II, III, knotted together by four disulfide bridges, with the most prominent, loop II, containing another disulfide close to its lower tip. Loop I is stabilized by one beta-turn and two beta-sheet hydrogen bonds; loop II by eight beta-sheet hydrogen bonds, with the tip folded into two distorted right-handed helical turns stabilized by two alpha-helical and two beta-turn hydrogen bonds; and loop III by hydrophobic interactions and one beta-turn. Loop II and one strand of loop III form an antiparallel triple-pleated beta-sheet, and tight anchoring of the Asn63 side chain fixes the tail segment. In the crystal lattice, the alpha-cobratoxin molecules dimerize by beta-sheet formation between strands 53 and 57 of symmetry-related molecules. Because such interactions are found also in a cardiotoxin and alpha-bungarotoxin, this could be of importance for interaction with acetylcholine receptor.

	~~==Function==~~		The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution.,Betzel C, Lange G, Pal GP, Wilson KS, Maelicke A, Saenger W J Biol Chem. 1991 Nov 15;266(32):21530-6. PMID:1939183<ref>PMID:1939183</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site~~. ~~Binds to muscular and neuronal~~ (~~only alpha-7 alpha-8 alpha~~-~~9) nicotinic acetylcholine receptors (By similarity)~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2ctx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_naja Naja naja]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:001939183</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Naja naja]]		[[Category: Naja naja]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]

OCA at 08:44, 23 April 2014

2014-04-23T08:44:54Z

← Older revision		Revision as of 08:44, 23 April 2014
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	~~[[Image:2ctx.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ctx", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ctx\| PDB=2ctx \| SCENE= }}		{{STRUCTURE_2ctx\| PDB=2ctx \| SCENE= }}

	===THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION===		===THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION===
			{{ABSTRACT_PUBMED_1939183}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/NXL3_NAJNA NXL3_NAJNA]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
	~~The line below this paragraph, {{ABSTRACT_PUBMED_1939183}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 1939183 is~~ the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_1939183}}~~

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
	<ref group="xtra">PMID:001939183</ref><references group="xtra"/>		<ref group="xtra">PMID:001939183</ref><references group="xtra"/><references/>
	[[Category: Naja naja]]		[[Category: Naja naja]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C.]]

OCA: Protected "2ctx" [edit=sysop:move=sysop]

2011-11-16T10:23:22Z

Protected "2ctx" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:23, 16 November 2011
(No difference)