2cui - Revision history

OCA at 11:31, 22 May 2024

2024-05-22T11:31:18Z

← Older revision		Revision as of 11:31, 22 May 2024
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	==Solution structure of the 31st fibronectin type III domain of the human tenascin X==		==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
	<StructureSection load='2cui' size='340' side='right'caption='[[2cui~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2cui' size='340' side='right'caption='[[2cui]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TNXB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [https://pdbe.org/2cui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [https://www.ebi.ac.uk/pdbsum/2cui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [https://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [https://pdbe.org/2cui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [https://www.ebi.ac.uk/pdbsum/2cui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [https://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.		[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>		[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	[[Category: Ohnishi, S]]		[[Category: Ohnishi S]]
	~~[[Category: Structural genomic~~]]		[[Category: Tochio N]]
	[[Category: Tochio, N]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Extracellular matirx]]~~
	~~[[Category: Fibronectin type iii domain]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Tenascin x precursor~~]]

OCA at 11:51, 3 February 2021

2021-02-03T11:51:10Z

← Older revision		Revision as of 11:51, 3 February 2021
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	==Solution structure of the 31st fibronectin type III domain of the human tenascin X==		==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
	<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cui' size='340' side='right'caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [~~http~~://pdbe.org/2cui PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cui PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [https://pdbe.org/2cui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [https://www.ebi.ac.uk/pdbsum/2cui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [https://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[~~http~~://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.		[[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>		[[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 07:57, 23 May 2018

2018-05-23T07:57:47Z

← Older revision		Revision as of 07:57, 23 May 2018
Line 1:		Line 1:

	==Solution structure of the 31st fibronectin type III domain of the human tenascin X==		==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
	<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://pdbe.org/2cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://pdbe.org/2cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cui ProSAT], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cui_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cui_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cui ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 11:08, 11 September 2015

2015-09-11T11:08:30Z

← Older revision		Revision as of 11:08, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://pdbe.org/2cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 17:24, 15 January 2015

2015-01-15T17:24:09Z

← Older revision		Revision as of 17:24, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.		[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: Ohnishi, S.]]		[[Category: Ohnishi, S]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Tochio, N.]]		[[Category: Tochio, N]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Extracellular matirx]]		[[Category: Extracellular matirx]]
Line 37:		Line 37:
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~
	[[Category: Tenascin x precursor]]		[[Category: Tenascin x precursor]]

OCA at 00:39, 30 September 2014

2014-09-30T00:39:58Z

← Older revision		Revision as of 00:39, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2cui\| PDB=2cui \| SCENE= }}~~		==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
	===Solution structure of the 31st fibronectin type III domain of the human tenascin X===		<StructureSection load='2cui' size='340' side='right' caption='[[2cui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUI FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cui RCSB], [http://www.ebi.ac.uk/pdbsum/2cui PDBsum], [http://www.topsan.org/Proteins/RSGI/2cui TOPSAN]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.		[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
			== Function ==
	==Function==		[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
	[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>		== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
	==~~About this Structure~~==		Check<jmol>
	[[~~2cui~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2CUI OCA~~].		<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cui_consurf.spt"</scriptWhenChecked>
	==~~Reference~~==		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<references ~~group="xtra"~~/><~~references~~/>		<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA at 10:35, 24 March 2013

2013-03-24T10:35:21Z

← Older revision		Revision as of 10:35, 24 March 2013
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	~~[[Image:2cui.png\|left\|200px]]~~

	{{STRUCTURE_2cui\| PDB=2cui \| SCENE= }}		{{STRUCTURE_2cui\| PDB=2cui \| SCENE= }}
			===Solution structure of the 31st fibronectin type III domain of the human tenascin X===

	===~~Solution structure of~~ the ~~31st fibronectin type III domain~~ of ~~the human~~ tenascin X~~===~~		==Disease==
			[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.

			==Function==
			[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>

	==About this Structure==		==About this Structure==
	[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].		[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "2cui" [edit=sysop:move=sysop]

2013-01-06T10:01:42Z

Protected "2cui" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:01, 6 January 2013
(No difference)

OCA at 10:01, 6 January 2013

2013-01-06T10:01:40Z

← Older revision		Revision as of 10:01, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2cui.png\|left\|200px]]		[[Image:2cui.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cui", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cui\| PDB=2cui \| SCENE= }}		{{STRUCTURE_2cui\| PDB=2cui \| SCENE= }}

	===Solution structure of the 31st fibronectin type III domain of the human tenascin X===		===Solution structure of the 31st fibronectin type III domain of the human tenascin X===


	~~==Disease==~~
	Known disease associated with this structure: Ehlers-Danlos due to tenascin X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]], Ehlers-Danlos syndrome, hypermobility type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]]

	==About this Structure==		==About this Structure==
	~~2CUI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].		[[2cui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
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	[[Category: Tochio, N.]]		[[Category: Tochio, N.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
			[[Category: Cell adhesion]]
	[[Category: Extracellular matirx]]		[[Category: Extracellular matirx]]
	[[Category: Fibronectin type iii domain]]		[[Category: Fibronectin type iii domain]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Tenascin x precursor]]		[[Category: Tenascin x precursor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 10:44:53 2008''~~

OCA at 08:44, 16 November 2008

2008-11-16T08:44:55Z

← Older revision		Revision as of 08:44, 16 November 2008
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	==About this Structure==		==About this Structure==
	2CUI is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].		2CUI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUI OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]
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	[[Category: Tenascin x precursor]]		[[Category: Tenascin x precursor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28~~ 16:34:43 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 10:44:53 2008''