2dbl - Revision history

OCA at 07:50, 23 October 2024

2024-10-23T07:50:48Z

← Older revision		Revision as of 07:50, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dbl_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dbl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:37, 22 May 2024

2024-05-22T11:37:32Z

← Older revision		Revision as of 11:37, 22 May 2024
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	<StructureSection load='2dbl' size='340' side='right'caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2dbl' size='340' side='right'caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [https://pdbe.org/2dbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [https://www.ebi.ac.uk/pdbsum/2dbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [https://pdbe.org/2dbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [https://www.ebi.ac.uk/pdbsum/2dbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbl ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Arevalo~~, J H~~]]		[[Category: Arevalo JH]]
	[[Category: Wilson~~, I A]]~~		[[Category: Wilson IA]]
	~~[[Category: Immunoglobulin~~]]

OCA at 10:29, 8 December 2021

2021-12-08T10:29:21Z

← Older revision		Revision as of 10:29, 8 December 2021
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	<StructureSection load='2dbl' size='340' side='right'caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2dbl' size='340' side='right'caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [~~http~~://pdbe.org/2dbl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dbl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [https://pdbe.org/2dbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [https://www.ebi.ac.uk/pdbsum/2dbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[Sandbox 20009\|Sandbox 20009]]
			*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:35, 4 March 2020

2020-03-04T07:35:38Z

← Older revision		Revision as of 07:35, 4 March 2020
Line 1:		Line 1:

	==MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY==		==MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY==
	<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2dbl' size='340' side='right'caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Arevalo, J H]]		[[Category: Arevalo, J H]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 06:14, 30 May 2018

2018-05-30T06:14:49Z

← Older revision		Revision as of 06:14, 30 May 2018
Line 1:		Line 1:

	==MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY==		==MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY==
	<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://pdbe.org/2dbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://pdbe.org/2dbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dbl_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dbl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dbl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:36, 11 September 2015

2015-09-11T16:36:13Z

← Older revision		Revision as of 16:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://pdbe.org/2dbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2dbl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Arevalo, J H]]		[[Category: Arevalo, J H]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 16:13, 15 January 2015

2015-01-15T16:13:16Z

← Older revision		Revision as of 16:13, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arevalo, J H.]]		[[Category: Arevalo, J H]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 02:12, 29 September 2014

2014-09-29T02:12:20Z

← Older revision		Revision as of 02:12, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2dbl~~.~~png~~\|~~left~~\|~~200px~~]]		==MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY==
			<StructureSection load='2dbl' size='340' side='right' caption='[[2dbl]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DBL FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S5H:5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE'>S5H</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dbl RCSB], [http://www.ebi.ac.uk/pdbsum/2dbl PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dbl_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Two major unanswered questions concerning the specificity of antibodies are: how do structurally different antigens bind with high affinity to the same antibody, and what are the limits of the antibody combining site complementarity and flexibility that contribute to such crossreactivity? We report here a comparative analysis of the X-ray structures of five conformationally different steroids in complex with the Fab' fragment of an anti-progesterone antibody DB3 at 2.7 A. This antibody is unable to complement completely the shape of the hydrophobic antigen so that crossreactivity occurs with other ligands without major structural rearrangements of the binding site. Antigen specificity can be explained through conserved interactions of DB3 with the steroid D-ring, whereas some of the crossreactivity is realized through different binding orientations of the steroid skeleton that place the A-ring into alternative pockets on the antibody surface. The restricted gene usage of the VGAM3.8 family in the generation of anti-progesterone monoclonal antibodies may be explained by the specific interaction of VH hallmark residues with the steroid D-ring. This first detailed structure of steroid interactions with a protein could be applied to the understanding of general mechanisms of steroid recognition as well as in the design of specific binding sites for small hydrophobic ligands.

	~~{{STRUCTURE_2dbl\| PDB=2dbl \| SCENE= }}~~		Molecular basis of crossreactivity and the limits of antibody-antigen complementarity.,Arevalo JH, Taussig MJ, Wilson IA Nature. 1993 Oct 28;365(6449):859-63. PMID:8413674<ref>PMID:8413674</ref>

	~~===MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_8413674}}~~

	~~==About this Structure==~~
	~~[[2dbl]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2DBL OCA].~~

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:008413674<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arevalo, J H.]]		[[Category: Arevalo, J H.]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 20:20, 20 October 2012

2012-10-20T20:20:22Z

← Older revision		Revision as of 20:20, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2dbl]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA].		[[2dbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBL OCA].

	==See Also==		==See Also==

OCA: Protected "2dbl" [edit=sysop:move=sysop]

2012-07-27T10:08:42Z

Protected "2dbl" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:08, 27 July 2012
(No difference)