2dda - Revision history

OCA at 07:55, 30 October 2024

2024-10-30T07:55:10Z

← Older revision		Revision as of 07:55, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2dda_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2dda_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:37, 22 May 2024

2024-05-22T11:37:48Z

← Older revision		Revision as of 11:37, 22 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ddb\|2ddb]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [https://pdbe.org/2dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [https://www.ebi.ac.uk/pdbsum/2dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [https://pdbe.org/2dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [https://www.ebi.ac.uk/pdbsum/2dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU]] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref>		[https://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Pseudechis australis]]		[[Category: Pseudechis australis]]
	[[Category: Fujimoto, Z]]		[[Category: Fujimoto Z]]
	[[Category: Mizuno, H]]		[[Category: Mizuno H]]
	[[Category: Morita, T]]		[[Category: Morita T]]
	[[Category: Suzuki, N]]		[[Category: Suzuki N]]
	[[Category: Yamazaki, Y]]		[[Category: Yamazaki Y]]
	~~[[Category: Cng channel]]~~
	~~[[Category: Crisp]]~~
	~~[[Category: Snake venom]]~~
	~~[[Category: Toxin~~]]

OCA at 10:30, 8 December 2021

2021-12-08T10:30:03Z

← Older revision		Revision as of 10:30, 8 December 2021
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	<StructureSection load='2dda' size='340' side='right'caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2dda' size='340' side='right'caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ddb\|2ddb]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [~~http~~://pdbe.org/2dda PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dda PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [https://pdbe.org/2dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [https://www.ebi.ac.uk/pdbsum/2dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU]] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref>		[[https://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU]] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:53, 4 March 2020

2020-03-04T07:53:34Z

← Older revision		Revision as of 07:53, 4 March 2020
Line 1:		Line 1:

	==Crystal structure of pseudechetoxin from Pseudechis australis==		==Crystal structure of pseudechetoxin from Pseudechis australis==
	<StructureSection load='2dda' size='340' side='right' caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2dda' size='340' side='right'caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDA FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Pseudechis australis]]		[[Category: Pseudechis australis]]
	[[Category: Fujimoto, Z]]		[[Category: Fujimoto, Z]]

OCA at 06:45, 30 May 2018

2018-05-30T06:45:01Z

← Older revision		Revision as of 06:45, 30 May 2018
Line 1:		Line 1:

	==Crystal structure of pseudechetoxin from Pseudechis australis==		==Crystal structure of pseudechetoxin from Pseudechis australis==
	<StructureSection load='2dda' size='340' side='right' caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2dda' size='340' side='right' caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://pdbe.org/2dda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://pdbe.org/2dda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2dda_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2dda_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:45, 9 February 2016

2016-02-09T22:45:44Z

← Older revision		Revision as of 22:45, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dda ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:47, 11 September 2015

2015-09-11T02:47:46Z

← Older revision		Revision as of 02:47, 11 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://pdbe.org/2dda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2dda" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:03, 25 December 2014

2014-12-25T10:03:47Z

← Older revision		Revision as of 10:03, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU]] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Pseudechis australis]]		[[Category: Pseudechis australis]]
	[[Category: Fujimoto, Z.]]		[[Category: Fujimoto, Z]]
	[[Category: Mizuno, H.]]		[[Category: Mizuno, H]]
	[[Category: Morita, T.]]		[[Category: Morita, T]]
	[[Category: Suzuki, N.]]		[[Category: Suzuki, N]]
	[[Category: Yamazaki, Y.]]		[[Category: Yamazaki, Y]]
	[[Category: Cng channel]]		[[Category: Cng channel]]
	[[Category: Crisp]]		[[Category: Crisp]]
	[[Category: Snake venom]]		[[Category: Snake venom]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 05:20, 29 September 2014

2014-09-29T05:20:13Z

← Older revision		Revision as of 05:20, 29 September 2014
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	[[Image:~~2dda~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of pseudechetoxin from Pseudechis australis==
			<StructureSection load='2dda' size='340' side='right' caption='[[2dda]], [[Resolution\|resolution]] 2.25Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ddb\|2ddb]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [http://www.ebi.ac.uk/pdbsum/2dda PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2dda_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction by retinal photoreceptors and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channels. These toxins belong to a cysteine-rich secretory protein (CRISP) family containing an N-terminal pathogenesis-related proteins of group 1 (PR-1) domain and a C-terminal cysteine-rich domain (CRD). PsTx and Pdc are highly homologous proteins, but their blocking affinities on CNG channels are different: PsTx blocks both the olfactory and retinal channels with approximately 15-30-fold higher affinity than Pdc. To gain further insights into their structure and function, the crystal structures of PsTx, Pdc and Zn2+-bound Pdc were determined. The structures revealed that most of the amino-acid-residue differences between PsTx and Pdc are located around the concave surface formed between the PR-1 domain and the CRD, suggesting that the concave surface is functionally important for CNG-channel binding and inhibition. A structural comparison in the presence and absence of Zn2+ ion demonstrated that the concave surface can open and close owing to movement of the CRD upon Zn2+ binding. The data suggest that PsTx and Pdc occlude the pore entrance and that the dynamic motion of the concave surface facilitates interaction with the CNG channels.

	~~{{STRUCTURE_2dda\| PDB=2dda \| SCENE= }}~~		Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain.,Suzuki N, Yamazaki Y, Brown RL, Fujimoto Z, Morita T, Mizuno H Acta Crystallogr D Biol Crystallogr. 2008 Oct;64(Pt 10):1034-42. Epub 2008, Sep 19. PMID:18931410<ref>PMID:18931410</ref>

	~~===Crystal structure~~ of ~~pseudechetoxin from Pseudechis australis===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18931410}}~~

	~~==About this Structure==~~
	~~[[2dda]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudechis_australis Pseudechis australis]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2DDA OCA].~~

	==See Also==		==See Also==
	*[[Pseudechetoxin\|Pseudechetoxin]]		*[[Pseudechetoxin\|Pseudechetoxin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018931410<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Pseudechis australis]]		[[Category: Pseudechis australis]]
	[[Category: Fujimoto, Z.]]		[[Category: Fujimoto, Z.]]

OCA at 15:24, 20 October 2012

2012-10-20T15:24:34Z

← Older revision		Revision as of 15:24, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2dda]] is a 4 chain structure ~~of [[Pseudechetoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA].		[[2dda]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA].

	==See Also==		==See Also==