2ddb - Revision history

OCA at 00:51, 21 November 2024

2024-11-21T00:51:55Z

← Older revision		Revision as of 00:51, 21 November 2024
Line 15:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 08:25, 25 October 2023

2023-10-25T08:25:39Z

← Older revision		Revision as of 08:25, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2ddb' size='340' side='right'caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ddb' size='340' side='right'caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Psepo Psepo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dda\|2dda]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [https://pdbe.org/2ddb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [https://www.ebi.ac.uk/pdbsum/2ddb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [https://pdbe.org/2ddb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [https://www.ebi.ac.uk/pdbsum/2ddb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CRVP_PSEPO CRVP_PSEPO]] Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.<ref>PMID:12234174</ref>		[https://www.uniprot.org/uniprot/CRVP_PSEPO CRVP_PSEPO] Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.<ref>PMID:12234174</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Psepo~~]]		[[Category: Pseudechis porphyriacus]]
	[[Category: Fujimoto, Z]]		[[Category: Fujimoto Z]]
	[[Category: Mizuno, H]]		[[Category: Mizuno H]]
	[[Category: Morita, T]]		[[Category: Morita T]]
	[[Category: Suzuki, N]]		[[Category: Suzuki N]]
	[[Category: Yamazaki, Y]]		[[Category: Yamazaki Y]]
	~~[[Category: Cng channel]]~~
	~~[[Category: Crisp]]~~
	~~[[Category: Snake venom]]~~
	~~[[Category: Toxin~~]]

OCA at 09:48, 5 May 2021

2021-05-05T09:48:44Z

← Older revision		Revision as of 09:48, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2ddb' size='340' side='right'caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ddb' size='340' side='right'caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Psepo Psepo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Psepo Psepo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dda\|2dda]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [~~http~~://pdbe.org/2ddb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ddb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [https://pdbe.org/2ddb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [https://www.ebi.ac.uk/pdbsum/2ddb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CRVP_PSEPO CRVP_PSEPO]] Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.<ref>PMID:12234174</ref>		[[https://www.uniprot.org/uniprot/CRVP_PSEPO CRVP_PSEPO]] Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.<ref>PMID:12234174</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:02, 24 July 2019

2019-07-24T09:02:55Z

← Older revision		Revision as of 09:02, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of pseudecin from Pseudechis porphyriacus==		==Crystal structure of pseudecin from Pseudechis porphyriacus==
	<StructureSection load='2ddb' size='340' side='right' caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ddb' size='340' side='right'caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psepo Psepo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psepo Psepo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ddb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ddb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Pseudechetoxin\|Pseudechetoxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Psepo]]		[[Category: Psepo]]
	[[Category: Fujimoto, Z]]		[[Category: Fujimoto, Z]]

OCA at 12:40, 12 October 2017

2017-10-12T12:40:36Z

← Older revision		Revision as of 12:40, 12 October 2017
Line 1:		Line 1:

	==Crystal structure of pseudecin from Pseudechis porphyriacus==		==Crystal structure of pseudecin from Pseudechis porphyriacus==
	<StructureSection load='2ddb' size='340' side='right' caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ddb' size='340' side='right' caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudechis_porphyriacus Pseudechis porphyriacus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psepo Psepo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://pdbe.org/2ddb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://pdbe.org/2ddb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ddb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ddb" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Pseudechetoxin\|Pseudechetoxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Pseudechis porphyriacus~~]]		[[Category: Psepo]]
	[[Category: Fujimoto, Z]]		[[Category: Fujimoto, Z]]
	[[Category: Mizuno, H]]		[[Category: Mizuno, H]]

OCA at 02:23, 9 February 2016

2016-02-09T02:23:14Z

← Older revision		Revision as of 02:23, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ddb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:41, 10 September 2015

2015-09-10T17:41:01Z

← Older revision		Revision as of 17:41, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://pdbe.org/2ddb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ddb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:45, 25 December 2014

2014-12-25T03:45:30Z

← Older revision		Revision as of 03:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CRVP_PSEPO CRVP_PSEPO]] Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.<ref>PMID:12234174</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Pseudechis porphyriacus]]		[[Category: Pseudechis porphyriacus]]
	[[Category: Fujimoto, Z.]]		[[Category: Fujimoto, Z]]
	[[Category: Mizuno, H.]]		[[Category: Mizuno, H]]
	[[Category: Morita, T.]]		[[Category: Morita, T]]
	[[Category: Suzuki, N.]]		[[Category: Suzuki, N]]
	[[Category: Yamazaki, Y.]]		[[Category: Yamazaki, Y]]
	[[Category: Cng channel]]		[[Category: Cng channel]]
	[[Category: Crisp]]		[[Category: Crisp]]
	[[Category: Snake venom]]		[[Category: Snake venom]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 03:24, 29 September 2014

2014-09-29T03:24:05Z

← Older revision		Revision as of 03:24, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2ddb~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of pseudecin from Pseudechis porphyriacus==
			<StructureSection load='2ddb' size='340' side='right' caption='[[2ddb]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dda\|2dda]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ddb RCSB], [http://www.ebi.ac.uk/pdbsum/2ddb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction by retinal photoreceptors and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channels. These toxins belong to a cysteine-rich secretory protein (CRISP) family containing an N-terminal pathogenesis-related proteins of group 1 (PR-1) domain and a C-terminal cysteine-rich domain (CRD). PsTx and Pdc are highly homologous proteins, but their blocking affinities on CNG channels are different: PsTx blocks both the olfactory and retinal channels with approximately 15-30-fold higher affinity than Pdc. To gain further insights into their structure and function, the crystal structures of PsTx, Pdc and Zn2+-bound Pdc were determined. The structures revealed that most of the amino-acid-residue differences between PsTx and Pdc are located around the concave surface formed between the PR-1 domain and the CRD, suggesting that the concave surface is functionally important for CNG-channel binding and inhibition. A structural comparison in the presence and absence of Zn2+ ion demonstrated that the concave surface can open and close owing to movement of the CRD upon Zn2+ binding. The data suggest that PsTx and Pdc occlude the pore entrance and that the dynamic motion of the concave surface facilitates interaction with the CNG channels.

	~~{{STRUCTURE_2ddb\| PDB=2ddb \| SCENE= }}~~		Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain.,Suzuki N, Yamazaki Y, Brown RL, Fujimoto Z, Morita T, Mizuno H Acta Crystallogr D Biol Crystallogr. 2008 Oct;64(Pt 10):1034-42. Epub 2008, Sep 19. PMID:18931410<ref>PMID:18931410</ref>

	~~===Crystal structure~~ of ~~pseudecin from Pseudechis porphyriacus===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18931410}}~~

	~~==About this Structure==~~
	~~[[2ddb]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2DDB OCA].~~

	==See Also==		==See Also==
	*[[Pseudechetoxin\|Pseudechetoxin]]		*[[Pseudechetoxin\|Pseudechetoxin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018931410<~~/~~ref~~><~~ref group="xtra">PMID:016597622</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Pseudechis porphyriacus]]		[[Category: Pseudechis porphyriacus]]
	[[Category: Fujimoto, Z.]]		[[Category: Fujimoto, Z.]]

OCA at 12:18, 20 October 2012

2012-10-20T12:18:56Z

← Older revision		Revision as of 12:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2ddb]] is a 4 chain structure ~~of [[Pseudechetoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA].		[[2ddb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudechis_porphyriacus Pseudechis porphyriacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDB OCA].

	==See Also==		==See Also==