2dhs - Revision history

OCA at 06:39, 1 May 2024

2024-05-01T06:39:32Z

← Older revision		Revision as of 06:39, 1 May 2024
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	==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==		==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==
	<StructureSection load='2dhs' size='340' side='right'caption='[[2dhs~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>		<StructureSection load='2dhs' size='340' side='right'caption='[[2dhs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CUGBP1 (AMINO ACIDS 1 - 187) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [https://pdbe.org/2dhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [https://www.ebi.ac.uk/pdbsum/2dhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [https://pdbe.org/2dhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [https://www.ebi.ac.uk/pdbsum/2dhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>		[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gao~~, X L~~]]		[[Category: Gao XL]]
	[[Category: Han~~, X G~~]]		[[Category: Han XG]]
	[[Category: Jun~~, K Y~~]]		[[Category: Jun KY]]
	[[Category: Swanson, M]]		[[Category: Swanson M]]
	[[Category: Timchenko, L]]		[[Category: Timchenko L]]
	[[Category: Xia~~, Y L~~]]		[[Category: Xia YL]]
	[[Category: Zhang, H]]		[[Category: Zhang H]]
	[[Category: Zhu, Q]]		[[Category: Zhu Q]]
	~~[[Category: Beta sheet]]~~
	~~[[Category: Rna binding protein]]~~
	~~[[Category: Two helices packed against the beta sheet~~]]

OCA at 07:02, 1 December 2021

2021-12-01T07:02:37Z

← Older revision		Revision as of 07:02, 1 December 2021
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	<StructureSection load='2dhs' size='340' side='right'caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='2dhs' size='340' side='right'caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [~~http~~://pdbe.org/2dhs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dhs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [https://pdbe.org/2dhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [https://www.ebi.ac.uk/pdbsum/2dhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>		[[https://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:32, 26 February 2020

2020-02-26T09:32:15Z

← Older revision		Revision as of 09:32, 26 February 2020
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	==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==		==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==
	<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='2dhs' size='340' side='right'caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Gao, X L]]		[[Category: Gao, X L]]
	[[Category: Han, X G]]		[[Category: Han, X G]]

OCA at 06:16, 30 May 2018

2018-05-30T06:16:32Z

← Older revision		Revision as of 06:16, 30 May 2018
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	==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==		==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==
	<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://pdbe.org/2dhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://pdbe.org/2dhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhs_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dhs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 08:18, 11 September 2015

2015-09-11T08:18:44Z

← Older revision		Revision as of 08:18, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://pdbe.org/2dhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~CUGB1_HUMAN CUGB1_HUMAN~~]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>		[[http://www.uniprot.org/uniprot/CELF1_HUMAN CELF1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Gao, X L]]		[[Category: Gao, X L]]
	[[Category: Han, X G]]		[[Category: Han, X G]]

OCA at 13:46, 25 December 2014

2014-12-25T13:46:03Z

← Older revision		Revision as of 13:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CUGB1_HUMAN CUGB1_HUMAN]] RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.<ref>PMID:10536163</ref> <ref>PMID:11124939</ref> <ref>PMID:11158314</ref> <ref>PMID:12799066</ref> <ref>PMID:12649496</ref> <ref>PMID:14726956</ref> <ref>PMID:16946708</ref> <ref>PMID:16601207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gao, X L.]]		[[Category: Gao, X L]]
	[[Category: Han, X G.]]		[[Category: Han, X G]]
	[[Category: Jun, K Y.]]		[[Category: Jun, K Y]]
	[[Category: Swanson, M.]]		[[Category: Swanson, M]]
	[[Category: Timchenko, L.]]		[[Category: Timchenko, L]]
	[[Category: Xia, Y L.]]		[[Category: Xia, Y L]]
	[[Category: Zhang, H.]]		[[Category: Zhang, H]]
	[[Category: Zhu, Q.]]		[[Category: Zhu, Q]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Two helices packed against the beta sheet]]		[[Category: Two helices packed against the beta sheet]]

OCA at 00:48, 30 September 2014

2014-09-30T00:48:55Z

← Older revision		Revision as of 00:48, 30 September 2014
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	~~[[Image:2dhs.png\|left\|200px]]~~		==Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA==
			<StructureSection load='2dhs' size='340' side='right' caption='[[2dhs]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	~~{{STRUCTURE_2dhs\| PDB=2dhs \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DHS FirstGlance]. <br>
	===Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA===		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CUGBP1 (AMINO ACIDS 1 - 187) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dhs RCSB], [http://www.ebi.ac.uk/pdbsum/2dhs PDBsum]</span></td></tr>
			<table>
	==~~About this Structure~~==		== Evolutionary Conservation ==
	[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA].		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhs_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gao, X L.]]		[[Category: Gao, X L.]]

OCA: Protected "2dhs" [edit=sysop:move=sysop]

2013-01-06T10:08:46Z

Protected "2dhs" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:08, 6 January 2013
(No difference)

OCA at 10:08, 6 January 2013

2013-01-06T10:08:45Z

← Older revision		Revision as of 10:08, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2dhs.png\|left\|200px]]		[[Image:2dhs.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2dhs", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2dhs\| PDB=2dhs \| SCENE= }}		{{STRUCTURE_2dhs\| PDB=2dhs \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2DHS~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA].		[[2dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gao, X L.]]		[[Category: Gao, X L.]]
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	[[Category: Zhu, Q.]]		[[Category: Zhu, Q.]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
			[[Category: Rna binding protein]]
	[[Category: Two helices packed against the beta sheet]]		[[Category: Two helices packed against the beta sheet]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:48:23 2009''~~

OCA at 15:48, 17 February 2009

2009-02-17T15:48:24Z

← Older revision		Revision as of 15:48, 17 February 2009
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	[[Image:2dhs.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2dhs.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2dhs\| PDB=2dhs \| SCENE= }}		{{STRUCTURE_2dhs\| PDB=2dhs \| SCENE= }}

	~~'''~~Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA~~'''~~		===Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA===


	==About this Structure==		==About this Structure==
	2DHS is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA].		2DHS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHS OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Gao, X L.]]		[[Category: Gao, X L.]]
	[[Category: Han, X G.]]		[[Category: Han, X G.]]
Line 26:		Line 26:
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Two helices packed against the beta sheet]]		[[Category: Two helices packed against the beta sheet]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 00~~:27:~~13 2008~~''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:48:23 2009''