2dnf - Revision history

OCA at 18:44, 29 May 2024

2024-05-29T18:44:51Z

← Older revision		Revision as of 18:44, 29 May 2024
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	==Solution structure of RSGI RUH-062, a DCX domain from human==		==Solution structure of RSGI RUH-062, a DCX domain from human==
	<StructureSection load='2dnf' size='340' side='right'caption='[[2dnf~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2dnf' size='340' side='right'caption='[[2dnf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DCDC2, KIAA1154 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [https://pdbe.org/2dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [https://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [https://pdbe.org/2dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [https://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[https://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>		[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[https://omim.org/entry/600202 600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).		[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi F]]
	[[Category: Hirota, H]]		[[Category: Hirota H]]
	[[Category: Nagashima, T]]		[[Category: Nagashima T]]
	[[Category: Ohashi, W]]		[[Category: Ohashi W]]
	~~[[Category: Structural genomic~~]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Doublecortin]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Rsgi~~]]

OCA at 11:30, 10 February 2021

2021-02-10T11:30:54Z

← Older revision		Revision as of 11:30, 10 February 2021
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	==Solution structure of RSGI RUH-062, a DCX domain from human==		==Solution structure of RSGI RUH-062, a DCX domain from human==
	<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2dnf' size='340' side='right'caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [~~http~~://pdbe.org/2dnf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [https://pdbe.org/2dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [https://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[~~http~~://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>		[[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[https://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).		[[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Hirota, H]]		[[Category: Hirota, H]]

OCA at 06:36, 30 May 2018

2018-05-30T06:36:29Z

← Older revision		Revision as of 06:36, 30 May 2018
Line 1:		Line 1:

	==Solution structure of RSGI RUH-062, a DCX domain from human==		==Solution structure of RSGI RUH-062, a DCX domain from human==
	<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://pdbe.org/2dnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://pdbe.org/2dnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:00, 8 February 2016

2016-02-08T08:00:30Z

← Older revision		Revision as of 08:00, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 09:29, 10 September 2015

2015-09-10T09:29:53Z

← Older revision		Revision as of 09:29, 10 September 2015
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	<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://pdbe.org/2dnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Hirota, H]]		[[Category: Hirota, H]]

OCA at 18:11, 15 January 2015

2015-01-15T18:11:43Z

← Older revision		Revision as of 18:11, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>		[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F]]
	[[Category: Hirota, H.]]		[[Category: Hirota, H]]
	[[Category: Nagashima, T.]]		[[Category: Nagashima, T]]
	[[Category: Ohashi, W.]]		[[Category: Ohashi, W]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Doublecortin]]		[[Category: Doublecortin]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~

OCA at 02:47, 30 September 2014

2014-09-30T02:47:27Z

← Older revision		Revision as of 02:47, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2dnf\| PDB=2dnf \| SCENE= }}~~		==Solution structure of RSGI RUH-062, a DCX domain from human==
	===Solution structure of RSGI RUH-062, a DCX domain from human===		<StructureSection load='2dnf' size='340' side='right' caption='[[2dnf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCDC2, KIAA1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [http://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
	==Function==		<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).		[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
			== Evolutionary Conservation ==
	==~~About this Structure~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	[[~~2dnf~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2DNF OCA~~].		Check<jmol>
			<jmolCheckbox>
	==~~Reference~~==		<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked>
	<references ~~group="xtra"~~/><~~references~~/>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 06:56, 25 March 2013

2013-03-25T06:56:58Z

← Older revision		Revision as of 06:56, 25 March 2013
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	~~[[Image:2dnf.png\|left\|200px]]~~

	{{STRUCTURE_2dnf\| PDB=2dnf \| SCENE= }}		{{STRUCTURE_2dnf\| PDB=2dnf \| SCENE= }}
			===Solution structure of RSGI RUH-062, a DCX domain from human===

	===~~Solution structure~~ of ~~RSGI RUH~~-~~062~~, ~~a DCX domain from human===~~		==Disease==
			[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).

	==About this Structure==		==About this Structure==
	[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].		[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA: Protected "2dnf" [edit=sysop:move=sysop]

2013-01-06T11:58:51Z

Protected "2dnf" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:58, 6 January 2013
(No difference)

OCA at 11:58, 6 January 2013

2013-01-06T11:58:47Z

← Older revision		Revision as of 11:58, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2dnf.png\|left\|200px]]		[[Image:2dnf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2dnf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2dnf\| PDB=2dnf \| SCENE= }}		{{STRUCTURE_2dnf\| PDB=2dnf \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2DNF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].		[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
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	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
			[[Category: Protein binding]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:33:59 2008''~~