2doa - Revision history

OCA at 18:45, 29 May 2024

2024-05-29T18:45:40Z

← Older revision		Revision as of 18:45, 29 May 2024
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	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
	<StructureSection load='2doa' size='340' side='right'caption='[[2doa~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2doa' size='340' side='right'caption='[[2doa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ELL, C19orf17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>		[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	~~[[Category: Structural genomic~~]]		[[Category: Saito K]]
	[[Category: Saito, K]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: C19orf17]]~~
	~~[[Category: Elongation factor]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Transcription~~]]

OCA at 11:33, 10 February 2021

2021-02-10T11:33:08Z

← Older revision		Revision as of 11:33, 10 February 2021
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	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2doa' size='340' side='right'caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [~~http~~://pdbe.org/2doa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2doa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>		[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 06:49, 30 May 2018

2018-05-30T06:49:57Z

← Older revision		Revision as of 06:49, 30 May 2018
Line 1:		Line 1:

	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 22:37, 11 September 2015

2015-09-11T22:37:09Z

← Older revision		Revision as of 22:37, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 17:10, 15 January 2015

2015-01-15T17:10:24Z

← Older revision		Revision as of 17:10, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Saito, K.]]		[[Category: Saito, K]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: C19orf17]]		[[Category: C19orf17]]
	[[Category: Elongation factor]]		[[Category: Elongation factor]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:11, 30 September 2014

2014-09-30T02:11:03Z

← Older revision		Revision as of 02:11, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}~~		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
	===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===		<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
			== Function ==
	==Function==		[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref><ref>PMID:16006523</ref><ref>PMID:20471948</ref><ref>PMID:20159561</ref><ref>PMID:22252557</ref>		== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
	==~~About this Structure~~==		Check<jmol>
	[[~~2doa~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2DOA OCA~~].		<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>
	==~~Reference~~==		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<references ~~group="xtra"~~/><~~references~~/>		<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA at 01:50, 25 March 2013

2013-03-25T01:50:25Z

← Older revision		Revision as of 01:50, 25 March 2013
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	~~[[Image:2doa.png\|left\|200px]]~~

	{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}		{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}
			===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===

	===~~Solution structure of the helical domain~~ in ~~human Eleven-nineteen lysine-rich leukemia~~ protein ~~ELL===~~		==Disease==
			[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.

			==Function==
			[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref><ref>PMID:16006523</ref><ref>PMID:20471948</ref><ref>PMID:20159561</ref><ref>PMID:22252557</ref>

	==About this Structure==		==About this Structure==
	[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].		[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "2doa" [edit=sysop:move=sysop]

2013-01-06T11:23:51Z

Protected "2doa" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:23, 6 January 2013
(No difference)

OCA at 11:23, 6 January 2013

2013-01-06T11:23:48Z

← Older revision		Revision as of 11:23, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2doa.png\|left\|200px]]		[[Image:2doa.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2doa", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}		{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2DOA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].		[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
			[[Category: Transcription]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun Nov 16 13:03:11 2008''~~

OCA at 11:03, 16 November 2008

2008-11-16T11:03:14Z

← Older revision		Revision as of 11:03, 16 November 2008
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	==About this Structure==		==About this Structure==
	2DOA is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].		2DOA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28 19~~:48:11 2008''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 13:03:11 2008''