2dwp - Revision history

OCA at 08:31, 25 October 2023

2023-10-25T08:31:29Z

← Older revision		Revision as of 08:31, 25 October 2023
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	<StructureSection load='2dwp' size='340' side='right'caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2dwp' size='340' side='right'caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [https://pdbe.org/2dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [https://www.ebi.ac.uk/pdbsum/2dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [https://pdbe.org/2dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [https://www.ebi.ac.uk/pdbsum/2dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.		[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN] Synthesis and degradation of fructose 2,6-bisphosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lee~~, Y H]]~~		[[Category: Lee YH]]
	~~[[Category: A ternary complex]]~~
	~~[[Category: Amppcp]]~~
	~~[[Category: Fructose-6-phosphate]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Transferase~~]]

OCA at 17:17, 15 December 2021

2021-12-15T17:17:50Z

← Older revision		Revision as of 17:17, 15 December 2021
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	<StructureSection load='2dwp' size='340' side='right'caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2dwp' size='340' side='right'caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [~~http~~://pdbe.org/2dwp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dwp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [https://pdbe.org/2dwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [https://www.ebi.ac.uk/pdbsum/2dwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.		[[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:22, 11 March 2020

2020-03-11T08:22:43Z

← Older revision		Revision as of 08:22, 11 March 2020
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	==A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB==		==A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB==
	<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2dwp' size='340' side='right'caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Lee, Y H]]		[[Category: Lee, Y H]]
	[[Category: A ternary complex]]		[[Category: A ternary complex]]

OCA at 06:28, 6 June 2018

2018-06-06T06:28:55Z

← Older revision		Revision as of 06:28, 6 June 2018
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	==A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB==		==A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB==
	<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://pdbe.org/2dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://pdbe.org/2dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwp_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:02, 7 February 2016

2016-02-07T20:02:07Z

← Older revision		Revision as of 20:02, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:34, 10 September 2015

2015-09-10T04:34:01Z

← Older revision		Revision as of 04:34, 10 September 2015
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	<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://pdbe.org/2dwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2dwp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Lee, Y H]]		[[Category: Lee, Y H]]
	[[Category: A ternary complex]]		[[Category: A ternary complex]]

OCA at 17:55, 24 December 2014

2014-12-24T17:55:04Z

← Older revision		Revision as of 17:55, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lee, Y H.]]		[[Category: Lee, Y H]]
	[[Category: A ternary complex]]		[[Category: A ternary complex]]
	[[Category: Amppcp]]		[[Category: Amppcp]]

OCA at 00:39, 30 September 2014

2014-09-30T00:39:37Z

← Older revision		Revision as of 00:39, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2dwp~~.~~png~~\|~~left~~\|~~200px~~]]		==A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB==
			<StructureSection load='2dwp' size='340' side='right' caption='[[2dwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWP FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2axn\|2axn]], [[2i1v\|2i1v]], [[2dwo\|2dwo]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwp RCSB], [http://www.ebi.ac.uk/pdbsum/2dwp PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwp_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			To understand the molecular basis of a phosphoryl transfer reaction catalyzed by the 6-phosphofructo-2-kinase domain of the hypoxia-inducible bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), the crystal structures of PFKFB3AMPPCPfructose-6-phosphate and PFKFB3ADPphosphoenolpyruvate complexes were determined to 2.7 A and 2.25 A resolution, respectively. Kinetic studies on the wild-type and site-directed mutant proteins were carried out to confirm the structural observations. The experimentally varied liganding states in the active pocket cause no significant conformational changes. In the pseudo-substrate complex, a strong direct interaction between AMPPCP and fructose-6-phosphate (Fru-6-P) is found. By virtue of this direct substrate-substrate interaction, Fru-6-P is aligned with AMPPCP in an orientation and proximity most suitable for a direct transfer of the gamma-phosphate moiety to 2-OH of Fru-6-P. The three key atoms involved in the phosphoryl transfer, the beta,gamma-phosphate bridge oxygen atom, the gamma-phosphorus atom, and the 2-OH group are positioned in a single line, suggesting a direct phosphoryl transfer without formation of a phosphoenzyme intermediate. In addition, the distance between 2-OH and gamma-phosphorus allows the gamma-phosphate oxygen atoms to serve as a general base catalyst to induce an "associative" phosphoryl transfer mechanism. The site-directed mutant study and inhibition kinetics suggest that this reaction will be catalyzed most efficiently by the protein when the substrates bind to the active pocket in an ordered manner in which ATP binds first.

	~~{{STRUCTURE_2dwp\| PDB=2dwp \| SCENE= }}~~		A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.,Kim SG, Cavalier M, El-Maghrabi MR, Lee YH J Mol Biol. 2007 Jun 29;370(1):14-26. Epub 2007 Mar 21. PMID:17499765<ref>PMID:17499765</ref>

	~~===A pseudo substrate complex of 6-phosphofructo-2-kinase~~ of ~~PFKFB===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17499765}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2dwp]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017499765<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lee, Y H.]]		[[Category: Lee, Y H.]]

OCA: Protected "2dwp" [edit=sysop:move=sysop]

2013-01-06T10:01:25Z

Protected "2dwp" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:01, 6 January 2013
(No difference)

OCA at 10:01, 6 January 2013

2013-01-06T10:01:20Z

← Older revision		Revision as of 10:01, 6 January 2013
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	[[Image:2dwp.png\|left\|200px]]		[[Image:2dwp.png\|left\|200px]]

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	{{STRUCTURE_2dwp\| PDB=2dwp \| SCENE= }}		{{STRUCTURE_2dwp\| PDB=2dwp \| SCENE= }}

	===A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB===		===A pseudo substrate complex of 6-phosphofructo-2-kinase of PFKFB===


	~~<!--~~
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	{{ABSTRACT_PUBMED_17499765}}		{{ABSTRACT_PUBMED_17499765}}

	==About this Structure==		==About this Structure==
	~~2DWP~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA].		[[2dwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWP OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17499765~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017499765</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lee, Y H.]]		[[Category: Lee, Y H.]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:10:59 2009''~~