2e2c - Revision history

OCA at 06:43, 9 August 2023

2023-08-09T06:43:28Z

← Older revision		Revision as of 06:43, 9 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin~~-~~-protein ligase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.~~2~~.19 6.3.2.19] </span>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [https://pdbe.org/2e2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [https://www.ebi.ac.uk/pdbsum/2e2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [https://pdbe.org/2e2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [https://www.ebi.ac.uk/pdbsum/2e2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).		[https://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Spisula solidissima]]		[[Category: Spisula solidissima]]
	~~[[Category: Ubiquitin--protein ligase]]~~		[[Category: Basavappa R]]
	[[Category: Basavappa, R]]		[[Category: Jiang F]]
	[[Category: Jiang, F]]
	~~[[Category: Ligase]]~~
	~~[[Category: Thioester bond]]~~
	~~[[Category: Ubiquitin carrier protein]]~~
	~~[[Category: Ubiquitin conjugation~~]]

OCA at 17:19, 15 December 2021

2021-12-15T17:19:40Z

← Older revision		Revision as of 17:19, 15 December 2021
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	<StructureSection load='2e2c' size='340' side='right'caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e2c' size='340' side='right'caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [~~http~~://pdbe.org/2e2c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e2c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [https://pdbe.org/2e2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [https://www.ebi.ac.uk/pdbsum/2e2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).		[[https://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[~~Ubiquitin~~ conjugating enzyme\|~~Ubiquitin~~ conjugating enzyme]]		*[[3D structures of ubiquitin conjugating enzyme\|3D structures of ubiquitin conjugating enzyme]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:25, 11 March 2020

2020-03-11T08:25:56Z

← Older revision		Revision as of 08:25, 11 March 2020
Line 1:		Line 1:

	==E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS==		==E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS==
	<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e2c' size='340' side='right'caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Spisula solidissima]]		[[Category: Spisula solidissima]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA at 06:38, 6 June 2018

2018-06-06T06:38:51Z

← Older revision		Revision as of 06:38, 6 June 2018
Line 1:		Line 1:

	==E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS==		==E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS==
	<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://pdbe.org/2e2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://pdbe.org/2e2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2c_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:37, 8 February 2016

2016-02-08T05:37:46Z

← Older revision		Revision as of 05:37, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e2c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:25, 10 September 2015

2015-09-10T08:25:39Z

← Older revision		Revision as of 08:25, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1br7 1br7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://pdbe.org/2e2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2e2c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:01, 24 December 2014

2014-12-24T21:01:32Z

← Older revision		Revision as of 21:01, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Spisula solidissima]]		[[Category: Spisula solidissima]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Basavappa, R.]]		[[Category: Basavappa, R]]
	[[Category: Jiang, F.]]		[[Category: Jiang, F]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Thioester bond]]		[[Category: Thioester bond]]
	[[Category: Ubiquitin carrier protein]]		[[Category: Ubiquitin carrier protein]]
	[[Category: Ubiquitin conjugation]]		[[Category: Ubiquitin conjugation]]

OCA at 11:07, 3 October 2014

2014-10-03T11:07:04Z

← Older revision		Revision as of 11:07, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2e2c\| PDB=2e2c \| SCENE= }}~~		==E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS==
	===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS===		<StructureSection load='2e2c' size='340' side='right' caption='[[2e2c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~{{ABSTRACT_PUBMED_10350465}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2c_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The destruction of the cyclin B protein is necessary for the cell to exit from mitosis. The destruction of cyclin B occurs via the ubiquitin/proteasome system and involves a specific ubiquitin-conjugating enzyme (Ubc) that donates ubiquitin to cyclin B. Here we present the crystal structure of the cyclin-specific Ubc from clam, E2-C, determined at 2.0 A resolution. The E2-C enzyme contains an N-terminal extension in addition to the Ubc core domain. The N-terminal extension is disordered, perhaps reflecting a need for flexibility as it interacts with various partners in the ubiquitination system. The overall structure of the E2-C core domain is quite similar to those in previously determined Ubc proteins. The interaction between particular pairs of E2-C proteins in the crystal has some of the hallmarks of a functional dimer, though solution studies suggest that the E2-C protein exists as a monomer. Comparison of the E2-C structure with that of the other available Ubc structures indicates conserved surface residues that may interact with common components of the ubiquitination system. Such comparison also reveals a remarkable spine of conserved hydrophobic residues in the center of the protein that may drive the protein to fold and stabilize the protein once folded. Comparison of residues conserved only among E2-C and its homologues indicates surface areas that may be involved in mitotic-specific ubiquitination.

	~~==Function==~~		Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution.,Jiang F, Basavappa R Biochemistry. 1999 May 18;38(20):6471-8. PMID:10350465<ref>PMID:10350465</ref>
	~~[[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor~~ of the ~~anaphase promoting complex/cyclosome (APC/C), a cell cycle~~-~~regulated~~ ubiquitin ~~ligase that is essential for the transition~~ from ~~metaphase to anaphase in mitosis~~. ~~Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins~~ A ~~and B at the exit of mitosis~~. ~~Acts by initiating polyubiquitin chains on APC/C substrates~~, ~~leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit~~ (~~By similarity~~).

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2e2c]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes~~ the ~~now removed PDB entries and [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2E2C OCA].~~		</div>

	==See Also==		==See Also==
	*[[Ubiquitin conjugating enzyme\|Ubiquitin conjugating enzyme]]		*[[Ubiquitin conjugating enzyme\|Ubiquitin conjugating enzyme]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:010350465</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Spisula solidissima]]		[[Category: Spisula solidissima]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA at 08:30, 23 April 2014

2014-04-23T08:30:43Z

← Older revision		Revision as of 08:30, 23 April 2014
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	~~[[Image:2e2c.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2e2c", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2e2c\| PDB=2e2c \| SCENE= }}		{{STRUCTURE_2e2c\| PDB=2e2c \| SCENE= }}

	===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS===		===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS===
			{{ABSTRACT_PUBMED_10350465}}

			==Function==
			[[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).

	~~<!--~~		==About this Structure==
	~~The line below~~ this ~~paragraph, {{ABSTRACT_PUBMED_10350465}}, adds the Publication Abstract to the page~~		[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA].
	~~(as it appears on PubMed at~~ http://~~www~~.~~pubmed~~.~~gov), where 10350465 is~~ the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_10350465}}~~

	==~~About this Structure~~==		==See Also==
	[[~~2e2c~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA].		*[[Ubiquitin conjugating enzyme\|Ubiquitin conjugating enzyme]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:010350465</ref><references group="xtra"/>		<ref group="xtra">PMID:010350465</ref><references group="xtra"/><references/>
	[[Category: Spisula solidissima]]		[[Category: Spisula solidissima]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA: Protected "2e2c" [edit=sysop:move=sysop]

2011-11-16T10:00:15Z

Protected "2e2c" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:00, 16 November 2011
(No difference)