2e2n - Revision history

OCA at 09:05, 6 November 2024

2024-11-06T09:05:26Z

← Older revision		Revision as of 09:05, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2n_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 08:34, 25 October 2023

2023-10-25T08:34:07Z

← Older revision		Revision as of 08:34, 25 October 2023
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	<StructureSection load='2e2n' size='340' side='right'caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2e2n' size='340' side='right'caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera~~ tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)~~-1~~-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [https://pdbe.org/2e2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [https://www.ebi.ac.uk/pdbsum/2e2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [https://pdbe.org/2e2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [https://www.ebi.ac.uk/pdbsum/2e2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2n ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q96Y14_SULTO Q96Y14_SULTO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Hexokinase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fushinobu, S]]		[[Category: Sulfurisphaera tokodaii]]
	[[Category: Nishimasu, H]]		[[Category: Fushinobu S]]
	[[Category: Shoun, H]]		[[Category: Nishimasu H]]
	[[Category: Wakagi, T]]		[[Category: Shoun H]]
	~~[[Category: Acetate and sugar kinase]]~~		[[Category: Wakagi T]]
	~~[[Category: Actin superfamily]]~~
	~~[[Category: Hsp70]]~~
	~~[[Category: Transferase~~]]

OCA at 17:19, 15 December 2021

2021-12-15T17:19:44Z

← Older revision		Revision as of 17:19, 15 December 2021
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	<StructureSection load='2e2n' size='340' side='right'caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2e2n' size='340' side='right'caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [~~http~~://pdbe.org/2e2n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e2n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [https://pdbe.org/2e2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [https://www.ebi.ac.uk/pdbsum/2e2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2n ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:26, 11 March 2020

2020-03-11T08:26:08Z

← Older revision		Revision as of 08:26, 11 March 2020
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	==Crystal structure of Sulfolobus tokodaii hexokinase in the apo form==		==Crystal structure of Sulfolobus tokodaii hexokinase in the apo form==
	<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2e2n' size='340' side='right'caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Hexokinase\|Hexokinase]]		*[[Hexokinase 3D structures\|Hexokinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
			[[Category: Large Structures]]
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]
	[[Category: Nishimasu, H]]		[[Category: Nishimasu, H]]

OCA at 06:45, 6 June 2018

2018-06-06T06:45:07Z

← Older revision		Revision as of 06:45, 6 June 2018
Line 1:		Line 1:

	==Crystal structure of Sulfolobus tokodaii hexokinase in the apo form==		==Crystal structure of Sulfolobus tokodaii hexokinase in the apo form==
	<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dsm_16993 Dsm 16993~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://pdbe.org/2e2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://pdbe.org/2e2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2n ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2n_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Dsm 16993]]~~
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]

OCA at 06:40, 7 February 2016

2016-02-07T06:40:24Z

← Older revision		Revision as of 06:40, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e2n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:49, 9 September 2015

2015-09-09T22:49:15Z

← Older revision		Revision as of 22:49, 9 September 2015
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	<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_tokodaii Sulfolobus tokodaii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://pdbe.org/2e2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2e2n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Dsm 16993]]
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	~~[[Category: Sulfolobus tokodaii]]~~
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]
	[[Category: Nishimasu, H]]		[[Category: Nishimasu, H]]

OCA at 16:27, 15 January 2015

2015-01-15T16:27:15Z

← Older revision		Revision as of 16:27, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Fushinobu, S.]]		[[Category: Fushinobu, S]]
	[[Category: Nishimasu, H.]]		[[Category: Nishimasu, H]]
	[[Category: Shoun, H.]]		[[Category: Shoun, H]]
	[[Category: Wakagi, T.]]		[[Category: Wakagi, T]]
	[[Category: Acetate and sugar kinase]]		[[Category: Acetate and sugar kinase]]
	[[Category: Actin superfamily]]		[[Category: Actin superfamily]]
	[[Category: Hsp70]]		[[Category: Hsp70]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:28, 29 September 2014

2014-09-29T03:28:25Z

← Older revision		Revision as of 03:28, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2e2n~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Sulfolobus tokodaii hexokinase in the apo form==
			<StructureSection load='2e2n' size='340' side='right' caption='[[2e2n]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2N FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2o\|2e2o]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2n RCSB], [http://www.ebi.ac.uk/pdbsum/2e2n PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2n_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hexokinase catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor. Recently, we identified and characterized an ATP-dependent hexokinase (StHK) from the hyperthermophilic archaeon Sulfolobus tokodaii, which can phosphorylate a broad range of sugar substrates, including glucose, mannose, glucosamine, and N-acetylglucosamine. Here we present the crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg(2+), and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not. The four different crystal structures of the same enzyme provide "snapshots" of the conformational changes during the catalytic cycle. StHK exhibits a core fold characteristic of the hexokinase family, but the structures of several loop regions responsible for substrate binding are significantly different from those of other known hexokinase family members. Structural comparison of StHK with human N-acetylglucosamine kinase and other hexokinases provides an explanation for the ability of StHK to phosphorylate both glucose and N-acetylglucosamine. A Mg(2+) ion and coordinating water molecules are well defined in the electron density of the quaternary complex structure. This structure represents the first direct visualization of the binding mode for magnesium to hexokinase and thus allows for a better understanding of the catalytic mechanism proposed for the entire hexokinase family.

	~~{{STRUCTURE_2e2n\| PDB=2e2n \| SCENE= }}~~		Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii.,Nishimasu H, Fushinobu S, Shoun H, Wakagi T J Biol Chem. 2007 Mar 30;282(13):9923-31. Epub 2007 Jan 17. PMID:17229727<ref>PMID:17229727</ref>

	~~===Crystal structure~~ of ~~Sulfolobus tokodaii hexokinase in~~ the ~~apo form===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17229727}}~~

	~~==About this Structure==~~
	~~[[2e2n]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2E2N OCA].~~

	==See Also==		==See Also==
	*[[Hexokinase\|Hexokinase]]		*[[Hexokinase\|Hexokinase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017229727<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]

OCA at 05:53, 20 October 2012

2012-10-20T05:53:06Z

← Older revision		Revision as of 05:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2e2n]] is a 2 chain structure ~~of [[Hexokinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA].		[[2e2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2N OCA].

	==See Also==		==See Also==