2e5d - Revision history

OCA at 08:35, 25 October 2023

2023-10-25T08:35:16Z

← Older revision		Revision as of 08:35, 25 October 2023
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	<StructureSection load='2e5d' size='340' side='right'caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e5d' size='340' side='right'caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2e5b\|2e5b]], [[2e5c\|2e5c]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [https://pdbe.org/2e5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [https://www.ebi.ac.uk/pdbsum/2e5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [https://pdbe.org/2e5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [https://www.ebi.ac.uk/pdbsum/2e5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).		[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Nicotinamide phosphoribosyltransferase]]~~		[[Category: Kobayashi Y]]
	[[Category: Kobayashi, Y]]		[[Category: Nakamura S]]
	[[Category: Nakamura, S]]		[[Category: Ohkubo T]]
	[[Category: Ohkubo, T]]		[[Category: Takahashi R]]
	[[Category: Takahashi, R]]
	~~[[Category: Nmprtase]]~~
	~~[[Category: Pbef]]~~
	~~[[Category: Prtase]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Visfatin~~]]

OCA at 17:20, 15 December 2021

2021-12-15T17:20:51Z

← Older revision		Revision as of 17:20, 15 December 2021
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	<StructureSection load='2e5d' size='340' side='right'caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e5d' size='340' side='right'caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e5b\|2e5b]], [[2e5c\|2e5c]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [~~http~~://pdbe.org/2e5d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e5d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [https://pdbe.org/2e5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [https://www.ebi.ac.uk/pdbsum/2e5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).		[[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:27, 11 March 2020

2020-03-11T08:27:53Z

← Older revision		Revision as of 08:27, 11 March 2020
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	==Crystal structure of Human NMPRTase complexed with nicotinamide==		==Crystal structure of Human NMPRTase complexed with nicotinamide==
	<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e5d' size='340' side='right'caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Kobayashi, Y]]		[[Category: Kobayashi, Y]]

OCA at 06:48, 6 June 2018

2018-06-06T06:48:37Z

← Older revision		Revision as of 06:48, 6 June 2018
Line 1:		Line 1:

	==Crystal structure of Human NMPRTase complexed with nicotinamide==		==Crystal structure of Human NMPRTase complexed with nicotinamide==
	<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://pdbe.org/2e5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://pdbe.org/2e5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5d_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:41, 10 February 2016

2016-02-10T04:41:30Z

← Older revision		Revision as of 04:41, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:28, 11 September 2015

2015-09-11T05:28:41Z

← Older revision		Revision as of 05:28, 11 September 2015
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	<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://pdbe.org/2e5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2e5d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Kobayashi, Y]]		[[Category: Kobayashi, Y]]

OCA at 11:51, 25 December 2014

2014-12-25T11:51:30Z

← Older revision		Revision as of 11:51, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Kobayashi, Y.]]		[[Category: Kobayashi, Y]]
	[[Category: Nakamura, S.]]		[[Category: Nakamura, S]]
	[[Category: Ohkubo, T.]]		[[Category: Ohkubo, T]]
	[[Category: Takahashi, R.]]		[[Category: Takahashi, R]]
	[[Category: Nmprtase]]		[[Category: Nmprtase]]
	[[Category: Pbef]]		[[Category: Pbef]]

OCA at 00:59, 30 September 2014

2014-09-30T00:59:33Z

← Older revision		Revision as of 00:59, 30 September 2014
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	[[Image:~~2e5d~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Human NMPRTase complexed with nicotinamide==
			<StructureSection load='2e5d' size='340' side='right' caption='[[2e5d]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5D FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e5b\|2e5b]], [[2e5c\|2e5c]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5d RCSB], [http://www.ebi.ac.uk/pdbsum/2e5d PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5d_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nicotinamide (NM) phosphoribosyltransferase (NMPRTase) catalyzes the reaction of NM and 5'-phosphoribosyl-1'-pyrophosphate (PRPP) to form NM mononucleotide (NMN) and pyrophosphate (PPi) in the pathway of NAD-biosynthesis. Monitoring the (1)H and (31)P NMR spectra of the reaction mixture, we found that this reaction is reversible as dictated by the equilibrium constant K = [NMN][PPi]/([NM][PRPP]) = 0.14, which agreed well with the ratio of second-order rate constants for forward and backward reactions, K = 0.16. The crystal structures of this enzyme in the free form and bound to NM and PRPP at the resolution of 2.0-2.2 A were essentially identical to that of the complex with NMN, except for some variations that could facilitate the substitution reaction by fixing the nucleophile and the leaving group for the requisite inversion of configuration at the C1' carbon of the ribose ring. In the active site near the C1' atom of the bound PRPP or NMN, there was neither negatively charged group nor waterproof environment necessary to support the feasibility of a ribo-oxocarbocation intermediate inherent in the S(N)1 mechanism. The structures and catalytic mechanism thus revealed are also discussed in connection with the multiple biological functions of NMPRTase.

	~~{{STRUCTURE_2e5d\| PDB=2e5d \| SCENE= }}~~		Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase.,Takahashi R, Nakamura S, Nakazawa T, Minoura K, Yoshida T, Nishi Y, Kobayashi Y, Ohkubo T J Biochem. 2010 Jan;147(1):95-107. Epub 2009 Oct 9. PMID:19819904<ref>PMID:19819904</ref>

	~~===Crystal structure~~ of ~~Human NMPRTase complexed with nicotinamide===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_19819904}}~~		==See Also==
			*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	==~~About this Structure~~==		== References ==
	[[~~2e5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5D OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:019819904<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]

OCA at 10:17, 6 January 2013

2013-01-06T10:17:10Z

← Older revision		Revision as of 10:17, 6 January 2013
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	[[Image:2e5d.png\|left\|200px]]		[[Image:2e5d.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2e5d", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2e5d\| PDB=2e5d \| SCENE= }}		{{STRUCTURE_2e5d\| PDB=2e5d \| SCENE= }}

	===Crystal structure of Human NMPRTase complexed with nicotinamide===		===Crystal structure of Human NMPRTase complexed with nicotinamide===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19819904}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19819904 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19819904}}		{{ABSTRACT_PUBMED_19819904}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19819904~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019819904</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
Line 29:		Line 18:
	[[Category: Ohkubo, T.]]		[[Category: Ohkubo, T.]]
	[[Category: Takahashi, R.]]		[[Category: Takahashi, R.]]
			[[Category: Nmprtase]]
			[[Category: Pbef]]
			[[Category: Prtase]]
			[[Category: Transferase]]
			[[Category: Visfatin]]

OCA: Protected "2e5d" [edit=sysop:move=sysop]

2011-03-02T06:16:02Z

Protected "2e5d" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:16, 2 March 2011
(No difference)