2e7f - Revision history

OCA at 08:35, 25 October 2023

2023-10-25T08:35:58Z

← Older revision		Revision as of 08:35, 25 October 2023
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	<StructureSection load='2e7f' size='340' side='right'caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e7f' size='340' side='right'caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35608 Atcc 35608~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7F FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C2F:5-METHYL~~-5,~~6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>[[1f6y\|1f6y]]~~, ~~[[1q8j\|1q8j]]~~, ~~[[1aj0\|1aj0]]~~, ~~[[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</div~~></td><~~/tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MeTr, acsE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [https://pdbe.org/2e7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [https://www.ebi.ac.uk/pdbsum/2e7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [https://pdbe.org/2e7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [https://www.ebi.ac.uk/pdbsum/2e7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACSE_MOOTH ACSE_MOOTH]] Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.<ref>PMID:17172470</ref> <ref>PMID:22419154</ref> <ref>PMID:7928975</ref>		[https://www.uniprot.org/uniprot/ACSE_MOOTH ACSE_MOOTH] Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.<ref>PMID:17172470</ref> <ref>PMID:22419154</ref> <ref>PMID:7928975</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 35608]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Doukov, T I~~]]		[[Category: Moorella thermoacetica]]
	[[Category: ~~Drennan, C L~~]]		[[Category: Doukov TI]]
	[[Category: ~~Hemmi, H~~]]		[[Category: Drennan CL]]
	[[Category: ~~Ragsdale, S W~~]]		[[Category: Hemmi H]]
	[[Category: ~~Corrionoid]]~~		[[Category: Ragsdale SW]]
	~~[[Category: Methyltetrahydrofolate-protein complex]]~~
	~~[[Category: Tim barrel]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Vitamin b12~~]]

OCA at 11:51, 10 February 2021

2021-02-10T11:51:59Z

← Older revision		Revision as of 11:51, 10 February 2021
Line 1:		Line 1:

	==5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution==		==5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution==
	<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e7f' size='340' side='right'caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35608 Atcc 35608]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E7F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35608 Atcc 35608]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [~~http~~://pdbe.org/2e7f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e7f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [https://pdbe.org/2e7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [https://www.ebi.ac.uk/pdbsum/2e7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACSE_MOOTH ACSE_MOOTH]] Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.<ref>PMID:17172470</ref> <ref>PMID:22419154</ref> <ref>PMID:7928975</ref>		[[https://www.uniprot.org/uniprot/ACSE_MOOTH ACSE_MOOTH]] Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.<ref>PMID:17172470</ref> <ref>PMID:22419154</ref> <ref>PMID:7928975</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 35608]]		[[Category: Atcc 35608]]
			[[Category: Large Structures]]
	[[Category: Doukov, T I]]		[[Category: Doukov, T I]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 06:57, 6 June 2018

2018-06-06T06:57:55Z

← Older revision		Revision as of 06:57, 6 June 2018
Line 1:		Line 1:

	==5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution==		==5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution==
	<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://pdbe.org/2e7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://pdbe.org/2e7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:32, 8 February 2016

2016-02-08T04:32:48Z

← Older revision		Revision as of 04:32, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e7f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:53, 10 September 2015

2015-09-10T07:53:57Z

← Older revision		Revision as of 07:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Moorella_thermoacetica Moorella thermoacetica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35608 Atcc 35608]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ~~Moorella thermoacetica~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 ATCC 35608])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://pdbe.org/2e7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACSE_MOOTH ACSE_MOOTH]] Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.<ref>PMID:17172470</ref> <ref>PMID:22419154</ref> <ref>PMID:7928975</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2e7f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Moorella thermoacetica~~]]		[[Category: Atcc 35608]]
	[[Category: Doukov, T I]]		[[Category: Doukov, T I]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 18:12, 15 January 2015

2015-01-15T18:12:10Z

← Older revision		Revision as of 18:12, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7F FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 Moorella thermoacetica])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 Moorella thermoacetica])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Moorella thermoacetica]]		[[Category: Moorella thermoacetica]]
	[[Category: Doukov, T I.]]		[[Category: Doukov, T I]]
	[[Category: Drennan, C L.]]		[[Category: Drennan, C L]]
	[[Category: Hemmi, H.]]		[[Category: Hemmi, H]]
	[[Category: Ragsdale, S W.]]		[[Category: Ragsdale, S W]]
	[[Category: Corrionoid]]		[[Category: Corrionoid]]
	[[Category: Methyltetrahydrofolate-protein complex]]		[[Category: Methyltetrahydrofolate-protein complex]]

OCA at 01:09, 30 September 2014

2014-09-30T01:09:57Z

← Older revision		Revision as of 01:09, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2e7f~~.~~png~~\|~~left~~\|~~200px~~]]		==5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution==
			<StructureSection load='2e7f' size='340' side='right' caption='[[2e7f]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7F FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f6y\|1f6y]], [[1q8j\|1q8j]], [[1aj0\|1aj0]], [[1ad4\|1ad4]], [[1tx0\|1tx0]], [[1tww\|1tww]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MeTr, acsE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 Moorella thermoacetica])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7f RCSB], [http://www.ebi.ac.uk/pdbsum/2e7f PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7f_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The methyltetrahydrofolate (CH(3)-H(4)folate) corrinoid-iron-sulfur protein (CFeSP) methyltransferase (MeTr) catalyzes transfer of the methyl group of CH(3)-H(4)folate to cob(I)amide. This key step in anaerobic CO and CO(2) fixation is similar to the first half-reaction in the mechanisms of other cobalamin-dependent methyltransferases. Methyl transfer requires electrophilic activation of the methyl group of CH(3)-H(4)folate, which includes proton transfer to the N5 group of the pterin ring and poises the methyl group for reaction with the Co(I) nucleophile. The structure of the binary CH(3)-H(4)folate/MeTr complex (revealed here) lacks any obvious proton donor near the N5 group. Instead, an Asn residue and water molecules are found within H-bonding distance of N5. Structural and kinetic experiments described here are consistent with the involvement of an extended H-bonding network in proton transfer to N5 of the folate that includes an Asn (Asn-199 in MeTr), a conserved Asp (Asp-160), and a water molecule. This situation is reminiscent of purine nucleoside phosphorylase, which involves protonation of the purine N7 in the transition state and is accomplished by an extended H-bond network that includes water molecules, a Glu residue, and an Asn residue (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Shi, W., Fedorov, A., Lewandowicz, A., Cahill, S. M., Almo, S. C., and Schramm, V. L. (2002) Biochemistry 41, 14489-14498). In MeTr, the Asn residue swings from a distant position to within H-bonding distance of the N5 atom upon CH(3)-H(4)folate binding. An N199A variant exhibits only approximately 20-fold weakened affinity for CH(3)-H(4)folate but a much more marked 20,000-40,000-fold effect on catalysis, suggesting that Asn-199 plays an important role in stabilizing a transition state or high energy intermediate for methyl transfer.

	~~{{STRUCTURE_2e7f\| PDB=2e7f \| SCENE= }}~~		Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.,Doukov TI, Hemmi H, Drennan CL, Ragsdale SW J Biol Chem. 2007 Mar 2;282(9):6609-18. Epub 2006 Dec 15. PMID:17172470<ref>PMID:17172470</ref>

	~~===5-methyltetrahydrofolate corrinoid~~/~~iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17172470}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2e7f]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Moorella_thermoacetica Moorella thermoacetica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017172470<~~/~~ref><ref group="xtra">PMID:010997901</ref~~><~~references group="xtra"~~/>
	[[Category: Moorella thermoacetica]]		[[Category: Moorella thermoacetica]]
	[[Category: Doukov, T I.]]		[[Category: Doukov, T I.]]

OCA at 12:15, 23 January 2013

2013-01-23T12:15:50Z

← Older revision		Revision as of 12:15, 23 January 2013
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	[[Image:2e7f.png\|left\|200px]]		[[Image:2e7f.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2e7f", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2e7f\| PDB=2e7f \| SCENE= }}		{{STRUCTURE_2e7f\| PDB=2e7f \| SCENE= }}

	===5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution===		===5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17172470}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17172470 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17172470}}		{{ABSTRACT_PUBMED_17172470}}

Line 22:		Line 11:

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17172470~~</ref><ref group="xtra">PMID:~~10997901~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017172470</ref><ref group="xtra">PMID:010997901</ref><references group="xtra"/>
	[[Category: Moorella thermoacetica]]		[[Category: Moorella thermoacetica]]
	[[Category: Doukov, T I.]]		[[Category: Doukov, T I.]]

OCA: Protected "2e7f" [edit=sysop:move=sysop]

2011-03-14T20:33:39Z

Protected "2e7f" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:33, 14 March 2011
(No difference)

OCA at 20:33, 14 March 2011

2011-03-14T20:33:37Z

← Older revision		Revision as of 20:33, 14 March 2011
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	~~{{Seed}}~~
	[[Image:2e7f.png\|left\|200px]]		[[Image:2e7f.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~2E7F~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA].		[[2e7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7F OCA].

	==Reference==		==Reference==
Line 32:		Line 31:
	[[Category: Methyltetrahydrofolate-protein complex]]		[[Category: Methyltetrahydrofolate-protein complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
			[[Category: Transferase]]
	[[Category: Vitamin b12]]		[[Category: Vitamin b12]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:50:07 2009''~~