2e95 - Revision history

OCA at 08:37, 25 October 2023

2023-10-25T08:37:10Z

← Older revision		Revision as of 08:37, 25 October 2023
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	<StructureSection load='2e95' size='340' side='right'caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e95' size='340' side='right'caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B75:1-HYDROXY~~-2~~-[3-(NAPHTHALENE-~~2~~-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[2dh4\|2dh4]~~], ~~[[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</div~~></td><~~/tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [https://pdbe.org/2e95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [https://www.ebi.ac.uk/pdbsum/2e95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e95 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [https://pdbe.org/2e95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [https://www.ebi.ac.uk/pdbsum/2e95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>		[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	~~[[Category: Heptaprenyl diphosphate synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cao, R]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chang~~, T H~~]]		[[Category: Cao R]]
	[[Category: Chen~~, C K.~~M]]		[[Category: Chang TH]]
	[[Category: Guo~~, R T~~]]		[[Category: Chen CK-M]]
	[[Category: Jeng~~, W Y~~]]		[[Category: Guo RT]]
	[[Category: Ko~~, T P~~]]		[[Category: Jeng WY]]
	[[Category: Liang~~, P H~~]]		[[Category: Ko TP]]
	[[Category: Oldfield, E]]		[[Category: Liang PH]]
	[[Category: Wang~~, A H.~~J]]		[[Category: Oldfield E]]
	~~[[Category: Bisphosphonate]]~~		[[Category: Wang AH-J]]
	~~[[Category: Farnesyl pyrophosphate]]~~
	~~[[Category: Prenyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 17:22, 15 December 2021

2021-12-15T17:22:07Z

← Older revision		Revision as of 17:22, 15 December 2021
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	<StructureSection load='2e95' size='340' side='right'caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e95' size='340' side='right'caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [~~http~~://pdbe.org/2e95 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e95 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e95 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [https://pdbe.org/2e95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [https://www.ebi.ac.uk/pdbsum/2e95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>		[[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:29, 11 March 2020

2020-03-11T08:29:43Z

← Older revision		Revision as of 08:29, 11 March 2020
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	==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675==		==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675==
	<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e95' size='340' side='right'caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Geranylgeranyl pyrophosphate synthase\|Geranylgeranyl pyrophosphate synthase]]		*[[Geranylgeranyl pyrophosphate synthase 3D structures\|Geranylgeranyl pyrophosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Heptaprenyl diphosphate synthase]]		[[Category: Heptaprenyl diphosphate synthase]]
			[[Category: Large Structures]]
	[[Category: Cao, R]]		[[Category: Cao, R]]
	[[Category: Chang, T H]]		[[Category: Chang, T H]]

OCA at 06:28, 6 June 2018

2018-06-06T06:28:51Z

← Older revision		Revision as of 06:28, 6 June 2018
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	==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675==		==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675==
	<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://pdbe.org/2e95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://pdbe.org/2e95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e95 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e95_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e95_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:47, 8 February 2016

2016-02-08T22:47:30Z

← Older revision		Revision as of 22:47, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e95 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:05, 10 September 2015

2015-09-10T16:05:37Z

← Older revision		Revision as of 16:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Trans-hexaprenyltranstransferase Trans-hexaprenyltranstransferase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://pdbe.org/2e95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2e95" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: ~~Trans-hexaprenyltranstransferase~~]]		[[Category: Heptaprenyl diphosphate synthase]]
	[[Category: Cao, R]]		[[Category: Cao, R]]
	[[Category: Chang, T H]]		[[Category: Chang, T H]]

OCA at 02:39, 25 December 2014

2014-12-25T02:39:10Z

← Older revision		Revision as of 02:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-hexaprenyltranstransferase Trans-hexaprenyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-hexaprenyltranstransferase Trans-hexaprenyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Trans-hexaprenyltranstransferase]]		[[Category: Trans-hexaprenyltranstransferase]]
	[[Category: Cao, R.]]		[[Category: Cao, R]]
	[[Category: Chang, T H.]]		[[Category: Chang, T H]]
	[[Category: Chen, C K.M.]]		[[Category: Chen, C K.M]]
	[[Category: Guo, R T.]]		[[Category: Guo, R T]]
	[[Category: Jeng, W Y.]]		[[Category: Jeng, W Y]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P]]
	[[Category: Liang, P H.]]		[[Category: Liang, P H]]
	[[Category: Oldfield, E.]]		[[Category: Oldfield, E]]
	[[Category: Wang, A H.J.]]		[[Category: Wang, A H.J]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]
	[[Category: Farnesyl pyrophosphate]]		[[Category: Farnesyl pyrophosphate]]
	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 23:44, 29 September 2014

2014-09-29T23:44:53Z

← Older revision		Revision as of 23:44, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2e95~~.~~png~~\|~~left~~\|~~200px~~]]		==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675==
			<StructureSection load='2e95' size='340' side='right' caption='[[2e95]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E95 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B75:1-HYDROXY-2-[3-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC+ACID'>B75</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dh4\|2dh4]], [[2e8t\|2e8t]], [[2e8u\|2e8u]], [[2e8v\|2e8v]], [[2e8w\|2e8w]], [[2e8x\|2e8x]], [[2e90\|2e90]], [[2e91\|2e91]], [[2e92\|2e92]], [[2e93\|2e93]], [[2e94\|2e94]], [[2e96\|2e96]], [[2e97\|2e97]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trans-hexaprenyltranstransferase Trans-hexaprenyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e95 RCSB], [http://www.ebi.ac.uk/pdbsum/2e95 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e95_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undecaprenyl diphosphate synthase (UPPS), a cis-prenyltransferase of interest as a target for antibacterial therapy. Our results on GGPPS (10 structures) show that there are three bisphosphonate-binding sites, consisting of FPP or isopentenyl diphosphate substrate-binding sites together with a GGPP product- or inhibitor-binding site. In UPPS, there are a total of four binding sites (in five structures). These results are of general interest because they provide the first structures of GGPPS- and UPPS-inhibitor complexes, potentially important drug targets, in addition to revealing a remarkably broad spectrum of binding modes not seen in FPPS inhibition.

	~~{{STRUCTURE_2e95\| PDB=2e95 \| SCENE= }}~~		Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.,Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. Epub 2007 May 29. PMID:17535895<ref>PMID:17535895</ref>

	~~===~~S. ~~cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_17535895}}~~		==See Also==
			*[[Geranylgeranyl pyrophosphate synthase\|Geranylgeranyl pyrophosphate synthase]]
	==~~About this Structure~~==		== References ==
	[[~~2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:017535895<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Trans-hexaprenyltranstransferase]]		[[Category: Trans-hexaprenyltranstransferase]]

OCA: Protected "2e95" [edit=sysop:move=sysop]

2013-01-06T09:15:13Z

Protected "2e95" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:15, 6 January 2013
(No difference)

OCA at 09:15, 6 January 2013

2013-01-06T09:15:08Z

← Older revision		Revision as of 09:15, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2e95.png\|left\|200px]]		[[Image:2e95.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2e95", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2e95\| PDB=2e95 \| SCENE= }}		{{STRUCTURE_2e95\| PDB=2e95 \| SCENE= }}

	===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675===		===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-675===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17535895}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17535895 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17535895}}		{{ABSTRACT_PUBMED_17535895}}

	==About this Structure==		==About this Structure==
	~~2E95~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA].		[[2e95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E95 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17535895~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017535895</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Trans-hexaprenyltranstransferase]]		[[Category: Trans-hexaprenyltranstransferase]]
Line 38:		Line 26:
	[[Category: Farnesyl pyrophosphate]]		[[Category: Farnesyl pyrophosphate]]
	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]
			[[Category: Transferase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 04:08:36 2009''~~