2eb7 - Revision history

OCA at 13:49, 13 March 2024

2024-03-13T13:49:33Z

← Older revision		Revision as of 13:49, 13 March 2024
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	<StructureSection load='2eb7' size='340' side='right'caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eb7' size='340' side='right'caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sulto Sulto~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ST1710 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=273063 SULTO])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [https://pdbe.org/2eb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eb7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [https://pdbe.org/2eb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eb7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q96ZY1_SULTO Q96ZY1_SULTO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eb7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eb7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The emergence of bacterial resistance to multiple drugs poses a serious and growing health concern. Understanding and deciphering the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.80 and 2.0A, respectively. The overall structure of the ST1710 dimer shares the topology of the MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif. We also show the protein-DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein-DNA interactions.

	Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7.,Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:17933554<ref>PMID:17933554</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2eb7" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Sulto~~]]		[[Category: Sulfurisphaera tokodaii str. 7]]
	[[Category: Kumarevel~~, T S~~]]		[[Category: Kumarevel TS]]
	[[Category: Nishio, M]]		[[Category: Nishio M]]
	~~[[Category: Structural genomic~~]]		[[Category: Shinkai A]]
	[[Category: Shinkai, A]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Hypothetical regulator]]~~
	~~[[Category: Mar family]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: St1710]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transcription regulator~~]]

OCA at 11:56, 10 February 2021

2021-02-10T11:56:02Z

← Older revision		Revision as of 11:56, 10 February 2021
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	==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==		==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==
	<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eb7' size='340' side='right'caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [~~http~~://pdbe.org/2eb7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eb7 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [https://pdbe.org/2eb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eb7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Sulto]]		[[Category: Sulto]]
	[[Category: Kumarevel, T S]]		[[Category: Kumarevel, T S]]

OCA at 06:50, 6 June 2018

2018-06-06T06:50:39Z

← Older revision		Revision as of 06:50, 6 June 2018
Line 1:		Line 1:

	==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==		==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==
	<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://pdbe.org/2eb7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://pdbe.org/2eb7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eb7 ProSAT], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2eb7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2eb7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eb7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:48, 11 September 2015

2015-09-11T16:48:52Z

← Older revision		Revision as of 16:48, 11 September 2015
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	<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_tokodaii Sulfolobus tokodaii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~111955 Sulfolobus tokodaii~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://pdbe.org/2eb7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2eb7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Sulfolobus tokodaii~~]]		[[Category: Sulto]]
	[[Category: Kumarevel, T S]]		[[Category: Kumarevel, T S]]
	[[Category: Nishio, M]]		[[Category: Nishio, M]]

OCA at 16:36, 15 January 2015

2015-01-15T16:36:55Z

← Older revision		Revision as of 16:36, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 Sulfolobus tokodaii])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 Sulfolobus tokodaii])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Kumarevel, T S.]]		[[Category: Kumarevel, T S]]
	[[Category: Nishio, M.]]		[[Category: Nishio, M]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Shinkai, A.]]		[[Category: Shinkai, A]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Hypothetical regulator]]		[[Category: Hypothetical regulator]]
	[[Category: Mar family]]		[[Category: Mar family]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: St1710]]		[[Category: St1710]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 00:09, 30 September 2014

2014-09-30T00:09:33Z

← Older revision		Revision as of 00:09, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2eb7~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7==
			<StructureSection load='2eb7' size='340' side='right' caption='[[2eb7]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EB7 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ST1710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 Sulfolobus tokodaii])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eb7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eb7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eb7 TOPSAN]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2eb7_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The emergence of bacterial resistance to multiple drugs poses a serious and growing health concern. Understanding and deciphering the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.80 and 2.0A, respectively. The overall structure of the ST1710 dimer shares the topology of the MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif. We also show the protein-DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein-DNA interactions.

	~~{{STRUCTURE_2eb7\| PDB=2eb7 \| SCENE= }}~~		Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7.,Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:17933554<ref>PMID:17933554</ref>

	~~===Crystal structure~~ of the ~~hypothetical regulator from Sulfolobus tokodaii 7===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17933554}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2eb7]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017933554<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Kumarevel, T S.]]		[[Category: Kumarevel, T S.]]

OCA: Protected "2eb7" [edit=sysop:move=sysop]

2013-01-06T09:35:31Z

Protected "2eb7" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:35, 6 January 2013
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OCA at 09:35, 6 January 2013

2013-01-06T09:35:26Z

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	~~{{Seed}}~~
	[[Image:2eb7.png\|left\|200px]]		[[Image:2eb7.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2eb7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2eb7\| PDB=2eb7 \| SCENE= }}		{{STRUCTURE_2eb7\| PDB=2eb7 \| SCENE= }}

	===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===		===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17933554}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17933554 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17933554}}		{{ABSTRACT_PUBMED_17933554}}

	==About this Structure==		==About this Structure==
	~~2EB7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].		[[2eb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17933554~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017933554</ref><references group="xtra"/>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Kumarevel, T S.]]		[[Category: Kumarevel, T S.]]
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	[[Category: St1710]]		[[Category: St1710]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
			[[Category: Transcription]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

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OCA at 02:09, 18 February 2009

2009-02-18T02:09:11Z

← Older revision		Revision as of 02:09, 18 February 2009
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	==Reference==		==Reference==
	Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7., Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S, J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17933554 17933554]~~		<ref group="xtra">PMID:17933554</ref><references group="xtra"/>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Kumarevel, T S.]]		[[Category: Kumarevel, T S.]]
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	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

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OCA at 08:04, 16 November 2008

2008-11-16T08:04:19Z

← Older revision		Revision as of 08:04, 16 November 2008
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	==About this Structure==		==About this Structure==
	2EB7 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].		2EB7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB7 OCA].

	==Reference==		==Reference==
	Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7., Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S, J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17933554 17933554]		Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7., Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S, J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17933554 17933554]
	~~[[Category: Single protein]]~~
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Kumarevel, T S.]]		[[Category: Kumarevel, T S.]]
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	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

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