2ec0 - Revision history

OCA at 08:38, 25 October 2023

2023-10-25T08:38:33Z

← Older revision		Revision as of 08:38, 25 October 2023
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	<StructureSection load='2ec0' size='340' side='right'caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2ec0' size='340' side='right'caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-~~mouth_disease_virus_c~~-~~s8c1~~ Foot-and-mouth disease virus c-~~s8c1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_C-S8c1 Foot-and-mouth disease virus C-S8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em~~;~~'>[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>3D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~244367 Foot-and-mouth disease virus C-S8c1])</td~~><~~/tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [https://pdbe.org/2ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [https://pdbe.org/2ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec0 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Foot-and-mouth disease virus c-~~s8c1~~]]		[[Category: Foot-and-mouth disease virus C-S8c1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: RNA-directed RNA polymerase]]~~		[[Category: Arias A]]
	[[Category: Arias, A]]		[[Category: Domingo E]]
	[[Category: Domingo, E]]		[[Category: Escarmis C]]
	[[Category: Escarmis, C]]		[[Category: Ferrer-Orta C]]
	[[Category: Ferrer-Orta, C]]		[[Category: Perez-Luque R]]
	[[Category: Perez-Luque, R]]		[[Category: Verdaguer N]]
	[[Category: Verdaguer, N]]
	~~[[Category: 3d polymerase]]~~
	~~[[Category: Foot-and- mouth disease virus]]~~
	~~[[Category: Polymerase]]~~
	~~[[Category: Rna-dependent rna polymerase]]~~
	~~[[Category: Transferase-rna complex~~]]

OCA at 11:57, 10 February 2021

2021-02-10T11:57:32Z

← Older revision		Revision as of 11:57, 10 February 2021
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	==RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP==		==RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP==
	<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2ec0' size='340' side='right'caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_c-s8c1 Foot-and-mouth disease virus c-s8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_c-s8c1 Foot-and-mouth disease virus c-s8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [~~http~~://pdbe.org/2ec0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ec0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [https://pdbe.org/2ec0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Foot-and-mouth disease virus c-s8c1]]		[[Category: Foot-and-mouth disease virus c-s8c1]]
			[[Category: Large Structures]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Arias, A]]		[[Category: Arias, A]]

OCA at 07:00, 6 June 2018

2018-06-06T07:00:58Z

← Older revision		Revision as of 07:00, 6 June 2018
Line 1:		Line 1:

	==RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP==		==RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP==
	<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://pdbe.org/2ec0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://pdbe.org/2ec0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:07, 11 September 2015

2015-09-11T10:07:36Z

← Older revision		Revision as of 10:07, 11 September 2015
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	<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_c-s8c1 Foot-and-mouth disease virus c-s8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10239 Viruses~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://pdbe.org/2ec0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ec0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Foot-and-mouth disease virus c-s8c1]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	~~[[Category: Viruses]]~~
	[[Category: Arias, A]]		[[Category: Arias, A]]
	[[Category: Domingo, E]]		[[Category: Domingo, E]]

OCA at 18:15, 15 January 2015

2015-01-15T18:15:59Z

← Older revision		Revision as of 18:15, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Arias, A.]]		[[Category: Arias, A]]
	[[Category: Domingo, E.]]		[[Category: Domingo, E]]
	[[Category: Escarmis, C.]]		[[Category: Escarmis, C]]
	[[Category: Ferrer-Orta, C.]]		[[Category: Ferrer-Orta, C]]
	[[Category: Perez-Luque, R.]]		[[Category: Perez-Luque, R]]
	[[Category: Verdaguer, N.]]		[[Category: Verdaguer, N]]
	[[Category: 3d polymerase]]		[[Category: 3d polymerase]]
	[[Category: Foot-and- mouth disease virus]]		[[Category: Foot-and- mouth disease virus]]

OCA at 10:10, 29 September 2014

2014-09-29T10:10:29Z

← Older revision		Revision as of 10:10, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2ec0~~.~~png~~\|~~left~~\|~~200px~~]]		==RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP==
			<StructureSection load='2ec0' size='340' side='right' caption='[[2ec0]], [[Resolution\|resolution]] 2.75Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EC0 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u09\|1u09]], [[1wne\|1wne]], [[2d7s\|2d7s]], [[2f8e\|2f8e]], [[2e9z\|2e9z]], [[2e9t\|2e9t]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ec0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ec0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ec0 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			RNA virus replication is an error-prone event caused by the low fidelity of viral RNA-dependent RNA polymerases. Replication fidelity can be decreased further by the use of mutagenic ribonucleoside analogs to a point where viral genetic information can no longer be maintained. For foot-and-mouth disease virus, the antiviral analogs ribavirin and 5-fluorouracil have been shown to be mutagenic, contributing to virus extinction through lethal mutagenesis. Here, we report the x-ray structure of four elongation complexes of foot-and-mouth disease virus polymerase 3D obtained in presence of natural substrates, ATP and UTP, or mutagenic nucleotides, ribavirin triphosphate and 5-fluorouridine triphosphate with different RNAs as template-primer molecules. The ability of these complexes to synthesize RNA in crystals allowed us to capture different successive replication events and to define the critical amino acids involved in (i) the recognition and positioning of the incoming nucleotide or analog; (ii) the positioning of the acceptor base of the template strand; and (iii) the positioning of the 3'-OH group of the primer nucleotide during RNA replication. The structures identify key interactions involved in viral RNA replication and provide insights into the molecular basis of the low fidelity of viral RNA polymerases.

	~~{{STRUCTURE_2ec0\| PDB=2ec0 \| SCENE= }}~~		Sequential structures provide insights into the fidelity of RNA replication.,Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N Proc Natl Acad Sci U S A. 2007 May 29;104(22):9463-8. Epub 2007 May 21. PMID:17517631<ref>PMID:17517631</ref>

	~~===RNA-dependent RNA polymerase~~ of ~~foot-and-mouth disease virus in complex with a template-primer RNA and ATP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17517631}}~~

	~~==About this Structure==~~
	~~[[2ec0]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Viruses Viruses]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].~~

	==See Also==		==See Also==
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase\|RNA polymerase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017517631<~~/~~ref~~><~~ref group="xtra">PMID:016364629</ref><ref group="xtra">PMID:015294895</ref><ref group="xtra">PMID:016216271</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Viruses]]		[[Category: Viruses]]

OCA at 18:03, 20 October 2012

2012-10-20T18:03:11Z

← Older revision		Revision as of 18:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2ec0]] is a 6 chain structure ~~of [[RNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].		[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
	<ref group="xtra">PMID:017517631~~</ref><ref group="xtra">PMID:016456546~~</ref><ref group="xtra">PMID:016364629</ref><ref group="xtra">PMID:015294895</ref><ref group="xtra">PMID:016216271</ref><references group="xtra"/>		<ref group="xtra">PMID:017517631</ref><ref group="xtra">PMID:016364629</ref><ref group="xtra">PMID:015294895</ref><ref group="xtra">PMID:016216271</ref><references group="xtra"/>
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Viruses]]		[[Category: Viruses]]

OCA at 02:49, 27 July 2012

2012-07-27T02:49:32Z

← Older revision		Revision as of 02:49, 27 July 2012
Line 1:		Line 1:
	[[Image:2ec0.png\|left\|200px]]		[[Image:2ec0.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ec0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ec0\| PDB=2ec0 \| SCENE= }}		{{STRUCTURE_2ec0\| PDB=2ec0 \| SCENE= }}

	===RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP===		===RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17517631}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17517631 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17517631}}		{{ABSTRACT_PUBMED_17517631}}

	==About this Structure==		==About this Structure==
	[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].		[[2ec0]] is a 6 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].

			==See Also==
			*[[RNA polymerase\|RNA polymerase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17517631~~</ref><ref group="xtra">PMID:~~16456546~~</ref><ref group="xtra">PMID:~~16364629~~</ref><ref group="xtra">PMID:~~15294895~~</ref><ref group="xtra">PMID:~~16216271~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017517631</ref><ref group="xtra">PMID:016456546</ref><ref group="xtra">PMID:016364629</ref><ref group="xtra">PMID:015294895</ref><ref group="xtra">PMID:016216271</ref><references group="xtra"/>
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Viruses]]		[[Category: Viruses]]
Line 35:		Line 27:
	[[Category: Polymerase]]		[[Category: Polymerase]]
	[[Category: Rna-dependent rna polymerase]]		[[Category: Rna-dependent rna polymerase]]
	[[Category: Transferase/rna complex]]		[[Category: Transferase-rna complex]]

OCA: Protected "2ec0" [edit=sysop:move=sysop]

2011-03-15T00:05:03Z

Protected "2ec0" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:05, 15 March 2011
(No difference)

OCA at 00:05, 15 March 2011

2011-03-15T00:05:02Z

← Older revision		Revision as of 00:05, 15 March 2011
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2ec0.png\|left\|200px]]		[[Image:2ec0.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
	~~2EC0~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Foot-and-mouth_disease_virus Foot-and-mouth disease virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].		[[2ec0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC0 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:17517631</ref><ref group="xtra">PMID:16456546</ref><ref group="xtra">PMID:16364629</ref><ref group="xtra">PMID:15294895</ref><ref group="xtra">PMID:16216271</ref><references group="xtra"/>		<ref group="xtra">PMID:17517631</ref><ref group="xtra">PMID:16456546</ref><ref group="xtra">PMID:16364629</ref><ref group="xtra">PMID:15294895</ref><ref group="xtra">PMID:16216271</ref><references group="xtra"/>
	~~[[Category: Foot-and-mouth disease virus]]~~
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
			[[Category: Viruses]]
	[[Category: Arias, A.]]		[[Category: Arias, A.]]
	[[Category: Domingo, E.]]		[[Category: Domingo, E.]]
Line 36:		Line 35:
	[[Category: Polymerase]]		[[Category: Polymerase]]
	[[Category: Rna-dependent rna polymerase]]		[[Category: Rna-dependent rna polymerase]]
			[[Category: Transferase/rna complex]]
	~~''Page seeded by~~ [~~http~~:/~~/oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 19:23:54 2009''~~