2ecf - Revision history

OCA at 00:53, 21 November 2024

2024-11-21T00:53:24Z

← Older revision		Revision as of 00:53, 21 November 2024
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	<StructureSection load='2ecf' size='340' side='right'caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ecf' size='340' side='right'caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas~~ maltophilia~~" hugh and ryschenkow 1961~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl~~-~~peptidase IV]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3~~.~~4.14.5 3.4.14.5] </span>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [https://pdbe.org/2ecf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [https://www.ebi.ac.uk/pdbsum/2ecf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [https://pdbe.org/2ecf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [https://www.ebi.ac.uk/pdbsum/2ecf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/P95782_STEMA P95782_STEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]~~
	~~[[Category: Dipeptidyl-peptidase IV]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Ito, K~~]]		[[Category: Stenotrophomonas maltophilia]]
	[[Category: ~~Nakajima, Y~~]]		[[Category: Ito K]]
	[[Category: ~~Yoshimoto, T~~]]		[[Category: Nakajima Y]]
	[[Category: ~~Dipeptidyl peptidase iv]]~~		[[Category: Yoshimoto T]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Peptidase family s9]]~~
	~~[[Category: Prolyl oligopeptidase family~~]]

OCA at 17:23, 15 December 2021

2021-12-15T17:23:11Z

← Older revision		Revision as of 17:23, 15 December 2021
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	<StructureSection load='2ecf' size='340' side='right'caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ecf' size='340' side='right'caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [~~http~~://pdbe.org/2ecf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ecf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [https://pdbe.org/2ecf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [https://www.ebi.ac.uk/pdbsum/2ecf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:31, 11 March 2020

2020-03-11T08:31:13Z

← Older revision		Revision as of 08:31, 11 March 2020
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	==Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia==		==Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia==
	<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ecf' size='340' side='right'caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]		[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
			[[Category: Large Structures]]
	[[Category: Ito, K]]		[[Category: Ito, K]]
	[[Category: Nakajima, Y]]		[[Category: Nakajima, Y]]

OCA at 06:48, 6 June 2018

2018-06-06T06:48:36Z

← Older revision		Revision as of 06:48, 6 June 2018
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	==Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia==		==Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia==
	<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://pdbe.org/2ecf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://pdbe.org/2ecf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:31, 11 September 2015

2015-09-11T14:31:57Z

← Older revision		Revision as of 14:31, 11 September 2015
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	<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Stenotrophomonas_maltophilia Stenotrophomonas~~ maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://pdbe.org/2ecf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ecf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	~~[[Category: Stenotrophomonas maltophilia]]~~
	[[Category: Ito, K]]		[[Category: Ito, K]]
	[[Category: Nakajima, Y]]		[[Category: Nakajima, Y]]

OCA at 17:55, 15 January 2015

2015-01-15T17:55:05Z

← Older revision		Revision as of 17:55, 15 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]
	[[Category: Ito, K.]]		[[Category: Ito, K]]
	[[Category: Nakajima, Y.]]		[[Category: Nakajima, Y]]
	[[Category: Yoshimoto, T.]]		[[Category: Yoshimoto, T]]
	[[Category: Dipeptidyl peptidase iv]]		[[Category: Dipeptidyl peptidase iv]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peptidase family s9]]		[[Category: Peptidase family s9]]
	[[Category: Prolyl oligopeptidase family]]		[[Category: Prolyl oligopeptidase family]]

OCA at 05:08, 29 September 2014

2014-09-29T05:08:18Z

← Older revision		Revision as of 05:08, 29 September 2014
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	[[Image:~~2ecf~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia==
			<StructureSection load='2ecf' size='340' side='right' caption='[[2ecf]], [[Resolution\|resolution]] 2.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecf RCSB], [http://www.ebi.ac.uk/pdbsum/2ecf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of dipeptidyl aminopeptidase IV from Stenotrophomonas maltophilia was determined at 2.8-A resolution by the multiple isomorphous replacement method, using platinum and selenomethionine derivatives. The crystals belong to space group P4(3)2(1)2, with unit cell parameters a = b = 105.9 A and c = 161.9 A. Dipeptidyl aminopeptidase IV is a homodimer, and the subunit structure is composed of two domains, namely, N-terminal beta-propeller and C-terminal catalytic domains. At the active site, a hydrophobic pocket to accommodate a proline residue of the substrate is conserved as well as those of mammalian enzymes. Stenotrophomonas dipeptidyl aminopeptidase IV exhibited activity toward a substrate containing a 4-hydroxyproline residue at the second position from the N terminus. In the Stenotrophomonas enzyme, one of the residues composing the hydrophobic pocket at the active site is changed to Asn611 from the corresponding residue of Tyr631 in the porcine enzyme, which showed very low activity against the substrate containing 4-hydroxyproline. The N611Y mutant enzyme was generated by site-directed mutagenesis. The activity of this mutant enzyme toward a substrate containing 4-hydroxyproline decreased to 30.6% of that of the wild-type enzyme. Accordingly, it was considered that Asn611 would be one of the major factors involved in the recognition of substrates containing 4-hydroxyproline.

	~~{{STRUCTURE_2ecf\| PDB=2ecf \| SCENE= }}~~		Dipeptidyl aminopeptidase IV from Stenotrophomonas maltophilia exhibits activity against a substrate containing a 4-hydroxyproline residue.,Nakajima Y, Ito K, Toshima T, Egawa T, Zheng H, Oyama H, Wu YF, Takahashi E, Kyono K, Yoshimoto T J Bacteriol. 2008 Dec;190(23):7819-29. Epub 2008 Sep 26. PMID:18820015<ref>PMID:18820015</ref>

	~~===Crystal Structure~~ of ~~Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18820015}}~~

	~~==About this Structure==~~
	~~[[2ecf]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2ECF OCA].~~

	==See Also==		==See Also==
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018820015<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]

OCA at 19:36, 20 October 2012

2012-10-20T19:36:26Z

← Older revision		Revision as of 19:36, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2ecf]] is a 1 chain structure ~~of [[Dipeptidyl peptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA].		[[2ecf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA].

	==See Also==		==See Also==

OCA: Protected "2ecf" [edit=sysop:move=sysop]

2012-07-27T07:54:03Z

Protected "2ecf" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:54, 27 July 2012
(No difference)

OCA at 07:54, 27 July 2012

2012-07-27T07:54:02Z

← Older revision		Revision as of 07:54, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2ecf.png\|left\|200px]]		[[Image:2ecf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ecf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ecf\| PDB=2ecf \| SCENE= }}		{{STRUCTURE_2ecf\| PDB=2ecf \| SCENE= }}

	===Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia===		===Crystal Structure of Dipeptidyl Aminopeptidase IV from Stenotrophomonas maltophilia===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18820015}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18820015 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18820015}}		{{ABSTRACT_PUBMED_18820015}}

	==About this Structure==		==About this Structure==
	~~2ECF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA].		[[2ecf]] is a 1 chain structure of [[Dipeptidyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECF OCA].

			==See Also==
			*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18820015~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018820015</ref><references group="xtra"/>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Stenotrophomonas maltophilia]]		[[Category: Stenotrophomonas maltophilia]]
Line 33:		Line 24:
	[[Category: Peptidase family s9]]		[[Category: Peptidase family s9]]
	[[Category: Prolyl oligopeptidase family]]		[[Category: Prolyl oligopeptidase family]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:36:08 2009''~~