2edb - Revision history

OCA at 18:49, 29 May 2024

2024-05-29T18:49:42Z

← Older revision		Revision as of 18:49, 29 May 2024
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	==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==		==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==
	<StructureSection load='2edb' size='340' side='right'caption='[[2edb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2edb' size='340' side='right'caption='[[2edb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DCC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [https://pdbe.org/2edb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [https://www.ebi.ac.uk/pdbsum/2edb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edb ProSAT], [https://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [https://pdbe.org/2edb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [https://www.ebi.ac.uk/pdbsum/2edb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edb ProSAT], [https://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>		[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>		[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kigawa, T]]		[[Category: Kigawa T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba S]]
	~~[[Category: Structural genomic~~]]		[[Category: Tochio N]]
	[[Category: Tochio, N]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Apoptosis]]~~
	~~[[Category: Colorectal cancer suppressor]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Tumor suppressor protein dcc~~]]

OCA at 12:00, 10 February 2021

2021-02-10T12:00:15Z

← Older revision		Revision as of 12:00, 10 February 2021
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	==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==		==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==
	<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2edb' size='340' side='right'caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [~~http~~://pdbe.org/2edb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2edb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2edb ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [https://pdbe.org/2edb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [https://www.ebi.ac.uk/pdbsum/2edb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edb ProSAT], [https://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[~~http~~://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>		[[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>		[[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba, S]]

OCA at 07:18, 6 June 2018

2018-06-06T07:18:00Z

← Older revision		Revision as of 07:18, 6 June 2018
Line 1:		Line 1:

	==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==		==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==
	<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://pdbe.org/2edb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://pdbe.org/2edb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2edb ProSAT], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:25, 9 February 2016

2016-02-09T12:25:16Z

← Older revision		Revision as of 12:25, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 22:13, 10 September 2015

2015-09-10T22:13:59Z

← Older revision		Revision as of 22:13, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://pdbe.org/2edb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

			==See Also==
			*[[Netrin receptor\|Netrin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S]]		[[Category: Koshiba, S]]

OCA at 18:43, 15 January 2015

2015-01-15T18:43:47Z

← Older revision		Revision as of 18:43, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>		[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T]]
	[[Category: Koshiba, S.]]		[[Category: Koshiba, S]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Tochio, N.]]		[[Category: Tochio, N]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Colorectal cancer suppressor]]		[[Category: Colorectal cancer suppressor]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~
	[[Category: Tumor suppressor protein dcc]]		[[Category: Tumor suppressor protein dcc]]

OCA at 03:07, 30 September 2014

2014-09-30T03:07:38Z

← Older revision		Revision as of 03:07, 30 September 2014
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	~~{{STRUCTURE_2edb\| PDB=2edb \| SCENE= }}~~		==Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC==
	===Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC===		<StructureSection load='2edb' size='340' side='right' caption='[[2edb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDB FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2edb RCSB], [http://www.ebi.ac.uk/pdbsum/2edb PDBsum], [http://www.topsan.org/Proteins/RSGI/2edb TOPSAN]</span></td></tr>
	==Function==		<table>
	[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref><ref>PMID:8187090</ref>		== Disease ==
			[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
	==~~About this Structure~~==		== Function ==
	[[~~2edb~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2EDB OCA~~].		[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
			== Evolutionary Conservation ==
	==~~Reference~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	<references ~~group="xtra"~~/><~~references~~/>		Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]

OCA at 07:22, 25 March 2013

2013-03-25T07:22:59Z

← Older revision		Revision as of 07:22, 25 March 2013
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	~~[[Image:2edb.png\|left\|200px]]~~

	{{STRUCTURE_2edb\| PDB=2edb \| SCENE= }}		{{STRUCTURE_2edb\| PDB=2edb \| SCENE= }}
			===Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC===

	===~~Solution structure~~ of the ~~fourth fibronectin type III domain~~ of ~~human Netrin receptor DCC===~~		==Disease==
			[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref><ref>PMID:8187090</ref>

	==About this Structure==		==About this Structure==
	[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA].		[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]

OCA: Protected "2edb" [edit=sysop:move=sysop]

2013-01-06T12:17:18Z

Protected "2edb" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:17, 6 January 2013
(No difference)

OCA at 12:17, 6 January 2013

2013-01-06T12:17:16Z

← Older revision		Revision as of 12:17, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2edb.png\|left\|200px]]		[[Image:2edb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2edb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2edb\| PDB=2edb \| SCENE= }}		{{STRUCTURE_2edb\| PDB=2edb \| SCENE= }}

	===Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC===		===Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC===


	~~==Disease==~~
	~~Known disease associated with this structure: Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120470 120470]]~~

	==About this Structure==		==About this Structure==
	~~2EDB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA].		[[2edb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDB OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Tumor suppressor protein dcc]]		[[Category: Tumor suppressor protein dcc]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 11:34:28 2009''~~