2eff - Revision history

OCA at 08:39, 25 October 2023

2023-10-25T08:39:20Z

← Older revision		Revision as of 08:39, 25 October 2023
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	<StructureSection load='2eff' size='340' side='right'caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eff' size='340' side='right'caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat~~">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1ew4\|1ew4]]~~, [[~~1soy~~\|~~1soy~~]]~~</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CYAY, B3807 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895]~~)</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [https://pdbe.org/2eff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [https://www.ebi.ac.uk/pdbsum/2eff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [https://pdbe.org/2eff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [https://www.ebi.ac.uk/pdbsum/2eff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eff ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CYAY_ECOLI CYAY_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Franzese, M]]		[[Category: Franzese M]]
	[[Category: Sica, F]]		[[Category: Sica F]]
	~~[[Category: Detoxifying redox-active iron]]~~
	~~[[Category: Frataxin]]~~
	~~[[Category: Friedreich's ataxia iron binding]]~~
	~~[[Category: Iron-sulfur cluster assembly]]~~
	~~[[Category: Unknown function~~]]

OCA at 12:04, 10 February 2021

2021-02-10T12:04:28Z

← Older revision		Revision as of 12:04, 10 February 2021
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	==Crystal structure analysis of the complex between CyaY and Co(II)==		==Crystal structure analysis of the complex between CyaY and Co(II)==
	<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eff' size='340' side='right'caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ew4\|1ew4]], [[1soy\|1soy]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [~~http~~://pdbe.org/2eff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [https://pdbe.org/2eff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [https://www.ebi.ac.uk/pdbsum/2eff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eff ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2eff" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2eff" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Frataxin 3D Structures\|Frataxin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Franzese, M]]		[[Category: Franzese, M]]
	[[Category: Sica, F]]		[[Category: Sica, F]]

OCA at 07:08, 6 June 2018

2018-06-06T07:08:36Z

← Older revision		Revision as of 07:08, 6 June 2018
Line 1:		Line 1:

	==Crystal structure analysis of the complex between CyaY and Co(II)==		==Crystal structure analysis of the complex between CyaY and Co(II)==
	<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://pdbe.org/2eff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://pdbe.org/2eff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eff ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2eff_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2eff_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:38, 7 February 2016

2016-02-07T07:38:48Z

← Older revision		Revision as of 07:38, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eff ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:15, 9 September 2015

2015-09-09T23:15:48Z

← Older revision		Revision as of 23:15, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://pdbe.org/2eff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2eff" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Franzese, M]]		[[Category: Franzese, M]]
	[[Category: Sica, F]]		[[Category: Sica, F]]

OCA at 09:02, 24 December 2014

2014-12-24T09:02:54Z

← Older revision		Revision as of 09:02, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Franzese, M.]]		[[Category: Franzese, M]]
	[[Category: Sica, F.]]		[[Category: Sica, F]]
	[[Category: Detoxifying redox-active iron]]		[[Category: Detoxifying redox-active iron]]
	[[Category: Frataxin]]		[[Category: Frataxin]]

OCA at 02:07, 30 September 2014

2014-09-30T02:07:56Z

← Older revision		Revision as of 02:07, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2eff~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure analysis of the complex between CyaY and Co(II)==
			<StructureSection load='2eff' size='340' side='right' caption='[[2eff]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ew4\|1ew4]], [[1soy\|1soy]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYAY, B3807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eff RCSB], [http://www.ebi.ac.uk/pdbsum/2eff PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2eff_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Deficiency of the small mitochondrial protein frataxin causes Friedreich's ataxia, a severe neurodegenerative pathology. Frataxin, which has been highly conserved throughout evolution, is thought to be involved in, among other processes, Fe-S cluster formation. Independent evidence shows that it binds iron directly, although with very distinct features and low affinity. Here, we have carried out an extensive study of the binding properties of CyaY, the bacterial ortholog of frataxin, to different divalent and trivalent cations, using NMR and X-ray crystallography. We demonstrate that the protein has low cation specificity and contains multiple binding sites able to chelate divalent and trivalent metals with low affinity. Binding does not involve cavities or pockets, but exposed glutamates and aspartates, which are residues that are unusual for iron chelation when not assisted by histidines and/or cysteines. We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function.

	~~{{STRUCTURE_2eff\| PDB=2eff \| SCENE= }}~~		Understanding the binding properties of an unusual metal-binding protein--a study of bacterial frataxin.,Pastore C, Franzese M, Sica F, Temussi P, Pastore A FEBS J. 2007 Aug;274(16):4199-210. Epub 2007 Jul 25. PMID:17651435<ref>PMID:17651435</ref>

	~~===Crystal structure analysis~~ of the ~~complex between CyaY and Co(II)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17651435}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2eff]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017651435<~~/~~ref~~><~~ref group="xtra">PMID:015530368</ref><ref group="xtra">PMID:010908679</ref><references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Franzese, M.]]		[[Category: Franzese, M.]]

OCA at 12:27, 23 January 2013

2013-01-23T12:27:45Z

← Older revision		Revision as of 12:27, 23 January 2013
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	[[Image:2eff.png\|left\|200px]]		[[Image:2eff.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2eff", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2eff\| PDB=2eff \| SCENE= }}		{{STRUCTURE_2eff\| PDB=2eff \| SCENE= }}

	===Crystal structure analysis of the complex between CyaY and Co(II)===		===Crystal structure analysis of the complex between CyaY and Co(II)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17651435}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17651435 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_17651435}}		{{ABSTRACT_PUBMED_17651435}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17651435~~</ref><ref group="xtra">PMID:~~15530368~~</ref><ref group="xtra">PMID:~~10908679~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017651435</ref><ref group="xtra">PMID:015530368</ref><ref group="xtra">PMID:010908679</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Franzese, M.]]		[[Category: Franzese, M.]]

OCA: Protected "2eff" [edit=sysop:move=sysop]

2011-03-14T22:43:13Z

Protected "2eff" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:43, 14 March 2011
(No difference)

OCA at 22:43, 14 March 2011

2011-03-14T22:43:11Z

← Older revision		Revision as of 22:43, 14 March 2011
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	~~{{Seed}}~~
	[[Image:2eff.png\|left\|200px]]		[[Image:2eff.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
	~~2EFF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA].		[[2eff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFF OCA].

	==Reference==		==Reference==
Line 27:		Line 26:
	[[Category: Franzese, M.]]		[[Category: Franzese, M.]]
	[[Category: Sica, F.]]		[[Category: Sica, F.]]
			[[Category: Detoxifying redox-active iron]]
	[[Category: Frataxin]]		[[Category: Frataxin]]
	[[Category: Friedreich's ataxia iron binding]]		[[Category: Friedreich's ataxia iron binding]]
	[[Category: Iron-sulfur cluster assembly~~,detoxifying redox-active iron~~]]		[[Category: Iron-sulfur cluster assembly]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:19:04 2009''~~