2eg7 - Revision history

OCA at 08:39, 25 October 2023

2023-10-25T08:39:45Z

← Older revision		Revision as of 08:39, 25 October 2023
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	<StructureSection load='2eg7' size='340' side='right'caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2eg7' size='340' side='right'caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OTD:2~~-~~OXO-1~~,2~~,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1xge\|1xge]]~~, ~~[[2eg6\|2eg6]]~~, ~~[[2eg8\|2eg8]]</div></td></tr>~~
	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b><~~/td><td class="sblockDat">PYRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [https://pdbe.org/2eg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [https://pdbe.org/2eg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg7 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/PYRC_ECOLI PYRC_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2eg7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2eg7" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dihydroorotase 3D structures\|Dihydroorotase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~		[[Category: Escherichia coli]]
	~~[[Category: Dihydroorotase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Guss~~, J M~~]]		[[Category: Guss JM]]
	[[Category: Lee, M]]		[[Category: Lee M]]
	[[Category: Maher~~, M J]]~~		[[Category: Maher MJ]]
	~~[[Category: Amidohydrolase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Tim barrel~~]]

OCA at 12:05, 10 February 2021

2021-02-10T12:05:40Z

← Older revision		Revision as of 12:05, 10 February 2021
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	==The crystal structure of E. coli dihydroorotase complexed with HDDP==		==The crystal structure of E. coli dihydroorotase complexed with HDDP==
	<StructureSection load='2eg7' size='340' side='right' caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2eg7' size='340' side='right'caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [~~http~~://pdbe.org/2eg7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eg7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [https://pdbe.org/2eg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2eg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2eg7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2eg7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydroorotase]]		[[Category: Dihydroorotase]]
			[[Category: Large Structures]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]
	[[Category: Lee, M]]		[[Category: Lee, M]]

OCA at 08:52, 12 October 2017

2017-10-12T08:52:00Z

← Older revision		Revision as of 08:52, 12 October 2017
Line 1:		Line 1:

	==The crystal structure of E. coli dihydroorotase complexed with HDDP==		==The crystal structure of E. coli dihydroorotase complexed with HDDP==
	<StructureSection load='2eg7' size='340' side='right' caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2eg7' size='340' side='right' caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://pdbe.org/2eg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://pdbe.org/2eg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eg7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eg7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:55, 11 September 2015

2015-09-11T23:55:24Z

← Older revision		Revision as of 23:55, 11 September 2015
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	<StructureSection load='2eg7' size='340' side='right' caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2eg7' size='340' side='right' caption='[[2eg7]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://pdbe.org/2eg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2eg7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydroorotase]]		[[Category: Dihydroorotase]]
	~~[[Category: Escherichia coli]]~~
	[[Category: Guss, J M]]		[[Category: Guss, J M]]
	[[Category: Lee, M]]		[[Category: Lee, M]]

OCA at 16:38, 15 January 2015

2015-01-15T16:38:15Z

← Older revision		Revision as of 16:38, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EG7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OTD:2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC+ACID'>OTD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xge\|1xge]], [[2eg6\|2eg6]], [[2eg8\|2eg8]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eg7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eg7 RCSB], [http://www.ebi.ac.uk/pdbsum/2eg7 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Dihydroorotase]]		[[Category: Dihydroorotase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Guss, J M.]]		[[Category: Guss, J M]]
	[[Category: Lee, M.]]		[[Category: Lee, M]]
	[[Category: Maher, M J.]]		[[Category: Maher, M J]]
	[[Category: Amidohydrolase]]		[[Category: Amidohydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 00:10, 30 September 2014

2014-09-30T00:10:19Z

@@ Line 1: / Line 1: @@
-[[Image:2eg7.png|left|200px]]
+==The crystal structure of E. coli dihydroorotase complexed with HDDP==
-{{STRUCTURE_2eg7|  PDB=2eg7  |  SCENE=  }}
+Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.,Lee M, Chan CW, Graham SC, Christopherson RI, Guss JM, Maher MJ J Mol Biol. 2007 Jul 27;370(5):812-25. Epub 2007 May 22. PMID:17550785<ref>PMID:17550785</ref>
-===The crystal structure of E. coli dihydroorotase complexed with HDDP===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_17550785}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA].
+</StructureSection>
 [[Category: Dihydroorotase]]
 [[Category: Escherichia coli]]

OCA: Protected "2eg7" [edit=sysop:move=sysop]

2013-01-06T09:36:01Z

Protected "2eg7" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:36, 6 January 2013
(No difference)

OCA at 09:35, 6 January 2013

2013-01-06T09:35:58Z

← Older revision		Revision as of 09:35, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2eg7.png\|left\|200px]]		[[Image:2eg7.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2eg7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2eg7\| PDB=2eg7 \| SCENE= }}		{{STRUCTURE_2eg7\| PDB=2eg7 \| SCENE= }}

	===The crystal structure of E. coli dihydroorotase complexed with HDDP===		===The crystal structure of E. coli dihydroorotase complexed with HDDP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17550785}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17550785 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17550785}}		{{ABSTRACT_PUBMED_17550785}}

	==About this Structure==		==About this Structure==
	~~2EG7~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA].		[[2eg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17550785~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017550785</ref><references group="xtra"/>
	[[Category: Dihydroorotase]]		[[Category: Dihydroorotase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 30:		Line 18:
	[[Category: Maher, M J.]]		[[Category: Maher, M J.]]
	[[Category: Amidohydrolase]]		[[Category: Amidohydrolase]]
			[[Category: Hydrolase]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:28:00 2009''~~

OCA at 05:28, 18 February 2009

2009-02-18T05:28:05Z

← Older revision		Revision as of 05:28, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2EG7 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA].		2EG7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EG7 OCA].

	==Reference==		==Reference==
	Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design., Lee M, Chan CW, Graham SC, Christopherson RI, Guss JM, Maher MJ, J Mol Biol. 2007 Jul 27;370(5):812-25. Epub 2007 May 22. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17550785 17550785]~~		<ref group="xtra">PMID:17550785</ref><references group="xtra"/>
	[[Category: Dihydroorotase]]		[[Category: Dihydroorotase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	~~[[Category: Single protein]]~~
	[[Category: Guss, J M.]]		[[Category: Guss, J M.]]
	[[Category: Lee, M.]]		[[Category: Lee, M.]]
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	[[Category: Tim barrel]]		[[Category: Tim barrel]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 14~~:00~~:41 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:28:00 2009''

OCA at 11:00, 29 July 2008

2008-07-29T11:00:46Z

← Older revision		Revision as of 11:00, 29 July 2008
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	[[Image:2eg7.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2eg7.png\|left\|200px]]

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	{{STRUCTURE_2eg7\| PDB=2eg7 \| SCENE= }}		{{STRUCTURE_2eg7\| PDB=2eg7 \| SCENE= }}

	~~'''~~The crystal structure of E. coli dihydroorotase complexed with HDDP~~'''~~		===The crystal structure of E. coli dihydroorotase complexed with HDDP===


	~~==Overview==~~		<!--
	~~Dihydroorotase (DHOase) catalyzes~~ the ~~reversible cyclization of N-carbamyl-L-aspartate (CA-asp)~~ to ~~L-dihydroorotate~~ (~~DHO) in the de novo biosynthesis of pyrimidine nucleotides. DHOase is a potential anti-malarial drug target~~ as ~~malarial parasites can only synthesize pyrimidines via the de novo pathway and do not possess a salvage pathway~~. ~~Here we report the structures of Escherichia coli DHOase crystallized without ligand (1~~.~~7 A resolution~~) ~~and in the presence of the inhibitors 2-oxo-1~~,~~2,3,6-tetrahydropyrimidine-4,6-dicarboxylate (HDDP; 2.0 A) and 5-fluoroorotate (FOA, 2.2 A). These are the first crystal structures of DHOase-inhibitor complexes, providing structural information on~~ the ~~mode of inhibitor binding~~. HDDP possesses features of both the substrate and product, and ligates the Zn atoms in the active site. In addition, HDDP forms hydrogen bonds to the flexible loop (residues 105-115) stabilizing the "loop-~~in" conformation of the flexible loop normally associated with the presence of CA~~-asp in the active site. By contrast, FOA, a product-like inhibitor, binds to the active site in a similar fashion to DHO but does not ligate the Zn atoms directly nor stabilize the loop-in conformation. These structures define the necessary features for the future design of improved inhibitors of DHOase.		The line below this paragraph, {{ABSTRACT_PUBMED_17550785}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 17550785 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_17550785}}

	==About this Structure==		==About this Structure==
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	[[Category: Amidohydrolase]]		[[Category: Amidohydrolase]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 02~~:30:07 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:00:41 2008''