2eoc - Revision history

OCA at 18:53, 29 May 2024

2024-05-29T18:53:25Z

← Older revision		Revision as of 18:53, 29 May 2024
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	==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==		==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==
	<StructureSection load='2eoc' size='340' side='right'caption='[[2eoc~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2eoc' size='340' side='right'caption='[[2eoc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [https://pdbe.org/2eoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [https://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [https://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [https://pdbe.org/2eoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [https://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [https://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>		[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi F]]
	[[Category: Nagashima, T]]		[[Category: Nagashima T]]
	~~[[Category: Structural genomic~~]]		[[Category: Yokoyama S]]
	[[Category: Yokoyama, S]]
	~~[[Category: Anti-parallel beta-sheet]]~~
	~~[[Category: Cell cycle control]]~~
	~~[[Category: Dna damage]]~~
	~~[[Category: Nad+]]~~
	~~[[Category: National project on protein structural and functional analyse]]~~
	~~[[Category: Nppsfa]]~~
	~~[[Category: Rsgi]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Transferase~~]]

OCA at 17:25, 15 December 2021

2021-12-15T17:25:58Z

← Older revision		Revision as of 17:25, 15 December 2021
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	<StructureSection load='2eoc' size='340' side='right'caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2eoc' size='340' side='right'caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [~~http~~://pdbe.org/2eoc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [https://pdbe.org/2eoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [https://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [https://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>		[[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:35, 11 March 2020

2020-03-11T08:35:36Z

← Older revision		Revision as of 08:35, 11 March 2020
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	==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==		==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==
	<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2eoc' size='340' side='right'caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]		*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Nagashima, T]]		[[Category: Nagashima, T]]

OCA at 06:58, 6 June 2018

2018-06-06T06:58:17Z

← Older revision		Revision as of 06:58, 6 June 2018
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	==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==		==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==
	<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://pdbe.org/2eoc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://pdbe.org/2eoc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eoc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eoc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eoc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 17:46, 11 September 2015

2015-09-11T17:46:53Z

← Older revision		Revision as of 17:46, 11 September 2015
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	<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://pdbe.org/2eoc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Nagashima, T]]		[[Category: Nagashima, T]]

OCA at 19:46, 25 December 2014

2014-12-25T19:46:48Z

← Older revision		Revision as of 19:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]		*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F]]
	[[Category: Nagashima, T.]]		[[Category: Nagashima, T]]
	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S]]
	[[Category: Anti-parallel beta-sheet]]		[[Category: Anti-parallel beta-sheet]]
	[[Category: Cell cycle control]]		[[Category: Cell cycle control]]
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	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	~~[[Category: Riken structural genomics/proteomics initiative]]~~
	[[Category: Rsgi]]		[[Category: Rsgi]]
	~~[[Category: Structural genomic]]~~
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:04, 29 September 2014

2014-09-29T03:04:43Z

← Older revision		Revision as of 03:04, 29 September 2014
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	~~[[Image:2eoc.png\|left\|200px]]~~		==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3==
			<StructureSection load='2eoc' size='340' side='right' caption='[[2eoc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{STRUCTURE_2eoc\| PDB=2eoc \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EOC FirstGlance]. <br>
	===Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3===		</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [http://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [http://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr>
			<table>
	==~~About this Structure~~==		== Evolutionary Conservation ==
	[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA].		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eoc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]		*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 20:43, 20 October 2012

2012-10-20T20:43:42Z

← Older revision		Revision as of 20:43, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2eoc]] is a 1 chain structure ~~of [[Poly (ADP-ribose) polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA].		[[2eoc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA].

	==See Also==		==See Also==

OCA: Protected "2eoc" [edit=sysop:move=sysop]

2012-07-27T11:25:28Z

Protected "2eoc" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:25, 27 July 2012
(No difference)

OCA at 11:25, 27 July 2012

2012-07-27T11:25:27Z

← Older revision		Revision as of 11:25, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2eoc.png\|left\|200px]]		[[Image:2eoc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2eoc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2eoc\| PDB=2eoc \| SCENE= }}		{{STRUCTURE_2eoc\| PDB=2eoc \| SCENE= }}

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	==About this Structure==		==About this Structure==
	~~2EOC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA].		[[2eoc]] is a 1 chain structure of [[Poly (ADP-ribose) polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA].

			==See Also==
			*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:39:02 2009''~~