2eph - Revision history

OCA at 07:38, 23 August 2023

2023-08-23T07:38:29Z

← Older revision		Revision as of 07:38, 23 August 2023
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	<StructureSection load='2eph' size='340' side='right'caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2eph' size='340' side='right'caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1a5c\|1a5c]]~~, [[~~2pc4~~\|~~2pc4~~]]~~</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.~~13 4.1.2.13] </span>~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [https://pdbe.org/2eph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [https://www.ebi.ac.uk/pdbsum/2eph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eph ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [https://pdbe.org/2eph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [https://www.ebi.ac.uk/pdbsum/2eph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eph ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/ALF_PLAFA ALF_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Fructose-bisphosphate aldolase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plafa]]~~		[[Category: Plasmodium berghei]]
	~~[[Category: Bosch, J]]~~
	~~[[Category: Buscaglia, C A]]~~
	~~[[Category: Cardozo, T]]~~
	~~[[Category: Hol, W G.J]]~~
	~~[[Category: Krumm, B]]~~
	~~[[Category: Nussenzweig, V]]~~
	~~[[Category: Structural genomic]]~~
	~~[[Category: Aldolase]]~~
	~~[[Category: Invasion machinery]]~~
	~~[[Category: Lyase~~]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: ~~PSI, Protein structure initiative~~]]		[[Category: Bosch J]]
	[[Category: ~~Sgpp~~]]		[[Category: Buscaglia CA]]
			[[Category: Cardozo T]]
			[[Category: Hol WGJ]]
			[[Category: Krumm B]]
			[[Category: Nussenzweig V]]

OCA at 15:56, 22 December 2021

2021-12-22T15:56:49Z

← Older revision		Revision as of 15:56, 22 December 2021
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	<StructureSection load='2eph' size='340' side='right'caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2eph' size='340' side='right'caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5c\|1a5c]], [[2pc4\|2pc4]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [~~http~~://pdbe.org/2eph PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eph PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eph ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [https://pdbe.org/2eph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [https://www.ebi.ac.uk/pdbsum/2eph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eph ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:40, 18 March 2020

2020-03-18T10:40:39Z

← Older revision		Revision as of 10:40, 18 March 2020
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	==Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution==		==Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution==
	<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2eph' size='340' side='right'caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase 3D structures\|Aldolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
			[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Bosch, J]]		[[Category: Bosch, J]]

OCA at 09:18, 14 June 2018

2018-06-14T09:18:54Z

← Older revision		Revision as of 09:18, 14 June 2018
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	==Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution==		==Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution==
	<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://pdbe.org/2eph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://pdbe.org/2eph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eph ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2eph_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2eph_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:07, 8 February 2016

2016-02-08T19:07:30Z

← Older revision		Revision as of 19:07, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eph ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:32, 10 September 2015

2015-09-10T14:32:15Z

← Older revision		Revision as of 14:32, 10 September 2015
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	<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://pdbe.org/2eph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2eph" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: ~~Plasmodium falciparum~~]]		[[Category: Plafa]]
	[[Category: Bosch, J]]		[[Category: Bosch, J]]
	[[Category: Buscaglia, C A]]		[[Category: Buscaglia, C A]]
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	[[Category: Invasion machinery]]		[[Category: Invasion machinery]]
	[[Category: Lyase]]		[[Category: Lyase]]
			[[Category: Plasmodium falciparum]]
	[[Category: PSI, Protein structure initiative]]		[[Category: PSI, Protein structure initiative]]
	[[Category: Sgpp]]		[[Category: Sgpp]]

OCA at 18:32, 15 January 2015

2015-01-15T18:32:56Z

← Older revision		Revision as of 18:32, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Bosch, J.]]		[[Category: Bosch, J]]
	[[Category: Buscaglia, C A.]]		[[Category: Buscaglia, C A]]
	[[Category: Cardozo, T.]]		[[Category: Cardozo, T]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J]]
	[[Category: Krumm, B.]]		[[Category: Krumm, B]]
	[[Category: Nussenzweig, V.]]		[[Category: Nussenzweig, V]]
	[[Category: ~~SGPP,~~ Structural ~~Genomics of Pathogenic Protozoa Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Aldolase]]		[[Category: Aldolase]]
	[[Category: Invasion machinery]]		[[Category: Invasion machinery]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: ~~Plasmodium falciparum]]~~		[[Category: PSI, Protein structure initiative]]
	~~[[Category:~~ Protein structure initiative]]
	~~[[Category: Psi~~]]
	[[Category: Sgpp]]		[[Category: Sgpp]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics of pathogenic protozoa consortium]]~~

OCA at 05:22, 29 September 2014

2014-09-29T05:22:54Z

← Older revision		Revision as of 05:22, 29 September 2014
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	[[Image:~~2eph~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution==
			<StructureSection load='2eph' size='340' side='right' caption='[[2eph]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EPH FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5c\|1a5c]], [[2pc4\|2pc4]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eph RCSB], [http://www.ebi.ac.uk/pdbsum/2eph PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2eph_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			An actomyosin motor located underneath the plasma membrane drives motility and host-cell invasion of apicomplexan parasites such as Plasmodium falciparum and Plasmodium vivax, the causative agents of malaria. Aldolase connects the motor actin filaments to transmembrane adhesive proteins of the thrombospondin-related anonymous protein (TRAP) family and transduces the motor force across the parasite surface. The TRAP-aldolase interaction is a distinctive and critical trait of host hepatocyte invasion by Plasmodium sporozoites, with a likely similar interaction crucial for erythrocyte invasion by merozoites. Here, we describe 2.4-A and 2.7-A structures of P. falciparum aldolase (PfAldo) obtained from crystals grown in the presence of the C-terminal hexapeptide of TRAP from Plasmodium berghei. The indole ring of the critical penultimate Trp-residue of TRAP fits snugly into a newly formed hydrophobic pocket, which is exclusively delimited by hydrophilic residues: two arginines, one glutamate, and one glutamine. Comparison with the unliganded PfAldo structure shows that the two arginines adopt new side-chain rotamers, whereas a 25-residue subdomain, forming a helix-loop-helix unit, shifts upon binding the TRAP-tail. The structural data are in agreement with decreased TRAP binding after mutagenesis of PfAldo residues in and near the induced TRAP-binding pocket. Remarkably, the TRAP- and actin-binding sites of PfAldo seem to overlap, suggesting that both the plasticity of the aldolase active-site region and the multimeric nature of the enzyme are crucial for its intriguing nonenzymatic function in the invasion machinery of the malaria parasite.

	~~{{STRUCTURE_2eph\| PDB=2eph \| SCENE= }}~~		Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.,Bosch J, Buscaglia CA, Krumm B, Ingason BP, Lucas R, Roach C, Cardozo T, Nussenzweig V, Hol WG Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7015-20. Epub 2007 Apr 10. PMID:17426153<ref>PMID:17426153</ref>

	~~===Crystal structure~~ of ~~fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2~~.~~7 angstrom resolution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17426153}}~~

	~~==About this Structure==~~
	~~[[2eph]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA].~~

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017426153<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 11:10, 20 October 2012

2012-10-20T11:10:22Z

← Older revision		Revision as of 11:10, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2eph]] is a 5 chain structure ~~of [[Aldolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA].		[[2eph]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPH OCA].

	==See Also==		==See Also==

OCA: Protected "2eph" [edit=sysop:move=sysop]

2012-07-26T04:28:10Z

Protected "2eph" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:28, 26 July 2012
(No difference)