2err - Revision history

OCA at 06:55, 9 March 2022

2022-03-09T06:55:33Z

← Older revision		Revision as of 06:55, 9 March 2022
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	</div>		</div>
	<div class="pdbe-citations 2err" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2err" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Entertaining PDB codes\|Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:26, 10 February 2021

2021-02-10T12:26:35Z

← Older revision		Revision as of 12:26, 10 February 2021
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	==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==		==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==
	<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2err' size='340' side='right'caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [~~http~~://pdbe.org/2err PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2err PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2err ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [https://pdbe.org/2err PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [https://www.ebi.ac.uk/pdbsum/2err PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2err ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RFOX1_HUMAN RFOX1_HUMAN]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref>		[[https://www.uniprot.org/uniprot/RFOX1_HUMAN RFOX1_HUMAN]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[~~User:Eric Martz/~~Entertaining PDB codes\|~~User:Eric Martz/~~Entertaining PDB codes]]		*[[Entertaining PDB codes\|Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Allain, F H]]		[[Category: Allain, F H]]
	[[Category: Auweter, S D]]		[[Category: Auweter, S D]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 08:37, 14 June 2018

2018-06-14T08:37:45Z

← Older revision		Revision as of 08:37, 14 June 2018
Line 1:		Line 1:

	==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==		==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==
	<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://pdbe.org/2err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://pdbe.org/2err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2err ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2err_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2err_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2err ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2err" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2err" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:47, 11 September 2015

2015-09-11T12:47:47Z

← Older revision		Revision as of 12:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://pdbe.org/2err PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~A2BP1_HUMAN A2BP1_HUMAN~~]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref>		[[http://www.uniprot.org/uniprot/RFOX1_HUMAN RFOX1_HUMAN]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2err" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Allain, F H]]		[[Category: Allain, F H]]
	[[Category: Auweter, S D]]		[[Category: Auweter, S D]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 16:39, 25 December 2014

2014-12-25T16:39:40Z

← Older revision		Revision as of 16:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/A2BP1_HUMAN A2BP1_HUMAN]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.]]		[[Category: Allain, F H]]
	[[Category: Auweter, S D.]]		[[Category: Auweter, S D]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 02:28, 30 September 2014

2014-09-30T02:28:56Z

← Older revision		Revision as of 02:28, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2err~~.~~png~~\|~~left~~\|~~200px~~]]		==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==
			<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2err_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a canonical way by the four-stranded beta-sheet of the RBD. In contrast, the first four nucleotides, UGCA, are bound by two loops of the protein in an unprecedented manner. Nucleotides U1, G2, and C3 are wrapped around a single phenylalanine, while G2 and A4 form a base-pair. This novel RNA binding site is independent from the beta-sheet binding interface. Surface plasmon resonance analyses were used to quantify the energetic contributions of electrostatic and hydrogen bond interactions to complex formation and support our structural findings. These results demonstrate the unusual molecular mechanism of sequence-specific RNA recognition by Fox-1, which is exceptional in its high affinity for a defined but short sequence element.

	~~{{STRUCTURE_2err\| PDB=2err \| SCENE= }}~~		Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.,Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH EMBO J. 2006 Jan 11;25(1):163-73. Epub 2005 Dec 15. PMID:16362037<ref>PMID:16362037</ref>

	~~===NMR Structure~~ of the ~~RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16362037}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2err]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016362037<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]

OCA: Protected "2err" [edit=sysop:move=sysop]

2013-01-06T11:41:03Z

Protected "2err" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:41, 6 January 2013
(No difference)

OCA at 11:40, 6 January 2013

2013-01-06T11:40:59Z

← Older revision		Revision as of 11:40, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2err.png\|left\|200px]]		[[Image:2err.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2err", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2err\| PDB=2err \| SCENE= }}		{{STRUCTURE_2err\| PDB=2err \| SCENE= }}

	===NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===		===NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16362037}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16362037 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16362037}}		{{ABSTRACT_PUBMED_16362037}}

	==About this Structure==		==About this Structure==
	~~2ERR~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].		[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16362037~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016362037</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]
	[[Category: Auweter, S D.]]		[[Category: Auweter, S D.]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
			[[Category: Rna binding protein]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 21:59:46 2009''~~

OCA at 19:59, 17 February 2009

2009-02-17T19:59:48Z

← Older revision		Revision as of 19:59, 17 February 2009
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	==About this Structure==		==About this Structure==
	2ERR is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].		2ERR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].

	==Reference==		==Reference==
	Molecular basis of RNA recognition by the human alternative splicing factor Fox-1., Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH, EMBO J. 2006 Jan 11;25(1):163-73. Epub 2005 Dec 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16362037 16362037]~~		<ref group="xtra">PMID:16362037</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]
	[[Category: Auweter, S D.]]		[[Category: Auweter, S D.]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:13:~~27 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:59:46 2009''

OCA at 03:13, 29 July 2008

2008-07-29T03:13:29Z

← Older revision		Revision as of 03:13, 29 July 2008
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	[[Image:2err.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2err.png\|left\|200px]]

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	{{STRUCTURE_2err\| PDB=2err \| SCENE= }}		{{STRUCTURE_2err\| PDB=2err \| SCENE= }}

	~~'''~~NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU~~'''~~		===NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===


	~~==Overview==~~		<!--
	~~The Fox~~-~~1 protein regulates alternative splicing of tissue~~-~~specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU.~~ The ~~last three nucleotides~~, ~~UGU~~, ~~are recognized in a canonical way by~~ the ~~four-stranded beta-sheet of~~ the ~~RBD~~. ~~In contrast, the first four nucleotides, UGCA, are bound by two loops of the protein in an unprecedented manner~~. ~~Nucleotides U1, G2, and C3 are wrapped around a single phenylalanine~~, ~~while G2 and A4 form a base-pair. This novel RNA binding site~~ is ~~independent from~~ the ~~beta-sheet binding interface~~. Surface plasmon resonance analyses were used to quantify the energetic contributions of electrostatic and hydrogen bond interactions to complex formation and support our structural findings. These results demonstrate the unusual molecular mechanism of sequence-~~specific RNA recognition by Fox~~-~~1, which is exceptional in its high affinity for a defined but short sequence element.~~		The line below this paragraph, {{ABSTRACT_PUBMED_16362037}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16362037 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16362037}}

	==About this Structure==		==About this Structure==
	2ERR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].		2ERR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].

	==Reference==		==Reference==
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	[[Category: Auweter, S D.]]		[[Category: Auweter, S D.]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 03~~:02:33 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:13:27 2008''