2ev5 - Revision history

OCA at 07:40, 23 August 2023

2023-08-23T07:40:04Z

← Older revision		Revision as of 07:40, 23 August 2023
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	<StructureSection load='2ev5' size='340' side='right'caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ev5' size='340' side='right'caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~mntR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [https://pdbe.org/2ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ev5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [https://pdbe.org/2ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.		[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]		[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brennan~~, R G~~]]		[[Category: Brennan RG]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld A]]
	[[Category: Griner~~, S L~~]]		[[Category: Griner SL]]
	[[Category: Helmann~~, J D~~]]		[[Category: Helmann JD]]
	[[Category: Kliegman~~, J I]]~~		[[Category: Kliegman JI]]
	~~[[Category: Dna-binding protein]]~~
	~~[[Category: Helix-turn-helix]]~~
	~~[[Category: Metalloregulatory protein]]~~
	~~[[Category: Transcription~~]]

OCA at 12:30, 10 February 2021

2021-02-10T12:30:48Z

← Older revision		Revision as of 12:30, 10 February 2021
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	==Bacillus subtilis manganese transport regulator (MNTR) bound to calcium==		==Bacillus subtilis manganese transport regulator (MNTR) bound to calcium==
	<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ev5' size='340' side='right'caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [~~http~~://pdbe.org/2ev5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ev5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ev5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [https://pdbe.org/2ev5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ev5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.		[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
			[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 08:42, 14 June 2018

2018-06-14T08:42:26Z

← Older revision		Revision as of 08:42, 14 June 2018
Line 1:		Line 1:

	==Bacillus subtilis manganese transport regulator (MNTR) bound to calcium==		==Bacillus subtilis manganese transport regulator (MNTR) bound to calcium==
	<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://pdbe.org/2ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://pdbe.org/2ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ev5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2ev5_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2ev5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus globigii migula 1900~~]]		[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 18:37, 9 February 2016

2016-02-09T18:37:17Z

← Older revision		Revision as of 18:37, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ev5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:57, 11 September 2015

2015-09-11T00:57:39Z

← Older revision		Revision as of 00:57, 11 September 2015
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	<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://pdbe.org/2ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ev5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Bacillus ~~subtilis~~]]		[[Category: Bacillus globigii migula 1900]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 08:43, 25 December 2014

2014-12-25T08:43:58Z

← Older revision		Revision as of 08:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A.]]		[[Category: Glasfeld, A]]
	[[Category: Griner, S L.]]		[[Category: Griner, S L]]
	[[Category: Helmann, J D.]]		[[Category: Helmann, J D]]
	[[Category: Kliegman, J I.]]		[[Category: Kliegman, J I]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:33, 30 September 2014

2014-09-30T02:33:26Z

← Older revision		Revision as of 02:33, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ev5~~.~~png~~\|~~left~~\|~~200px~~]]		==Bacillus subtilis manganese transport regulator (MNTR) bound to calcium==
			<StructureSection load='2ev5' size='340' side='right' caption='[[2ev5]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EV5 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2ev0\|2ev0]], [[2ev6\|2ev6]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ev5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ev5 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2ev5_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The manganese transport regulator (MntR) of Bacillus subtilis is activated by Mn(2+) to repress transcription of genes encoding transporters involved in the uptake of manganese. MntR is also strongly activated by cadmium, both in vivo and in vitro, but it is poorly activated by other metal cations, including calcium and zinc. The previously published MntR.Mn(2+) structure revealed a binuclear complex of manganese ions with a metal-metal separation of 3.3 A (herein designated the AB conformer). Analysis of four additional crystal forms of MntR.Mn(2+) reveals that the AB conformer is only observed in monoclinic crystals at 100 K, suggesting that this conformation may be stabilized by crystal packing forces. In contrast, monoclinic crystals analyzed at room temperature (at either pH 6.5 or pH 8.5), and a second hexagonal crystal form (analyzed at 100 K), all reveal the shift of one manganese ion by 2.5 A, thereby leading to a newly identified conformation (the AC conformer) with an internuclear distance of 4.4 A. Significantly, the cadmium and calcium complexes of MntR also contain binuclear complexes with a 4.4 A internuclear separation. In contrast, the zinc complex of MntR contains only one metal ion per subunit, in the A site. Isothermal titration calorimetry confirms the stoichiometry of Mn(2+), Cd(2+), and Zn(2+) binding to MntR. We propose that the specificity of MntR activation is tied to productive binding of metal ions at two sites; the A site appears to act as a selectivity filter, determining whether the B or C site will be occupied and thereby fully activate MntR.

	~~{{STRUCTURE_2ev5\| PDB=2ev5 \| SCENE= }}~~		Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.,Kliegman JI, Griner SL, Helmann JD, Brennan RG, Glasfeld A Biochemistry. 2006 Mar 21;45(11):3493-505. PMID:16533030<ref>PMID:16533030</ref>

	~~===Bacillus subtilis manganese transport regulator (MNTR) bound to calcium===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16533030}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ev5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016533030<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA: Protected "2ev5" [edit=sysop:move=sysop]

2013-01-06T11:45:45Z

Protected "2ev5" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:45, 6 January 2013
(No difference)

OCA at 11:45, 6 January 2013

2013-01-06T11:45:42Z

← Older revision		Revision as of 11:45, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2ev5.png\|left\|200px]]		[[Image:2ev5.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ev5", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ev5\| PDB=2ev5 \| SCENE= }}		{{STRUCTURE_2ev5\| PDB=2ev5 \| SCENE= }}

	===Bacillus subtilis manganese transport regulator (MNTR) bound to calcium===		===Bacillus subtilis manganese transport regulator (MNTR) bound to calcium===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16533030}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16533030 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16533030}}		{{ABSTRACT_PUBMED_16533030}}

	==About this Structure==		==About this Structure==
	~~2EV5~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA].		[[2ev5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16533030~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016533030</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
Line 33:		Line 21:
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
			[[Category: Transcription]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:53:41 2009''~~

OCA at 09:53, 17 February 2009

2009-02-17T09:53:43Z

← Older revision		Revision as of 09:53, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2EV5 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA].		2EV5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EV5 OCA].

	==Reference==		==Reference==
	Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis., Kliegman JI, Griner SL, Helmann JD, Brennan RG, Glasfeld A, Biochemistry. 2006 Mar 21;45(11):3493-505. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16533030 16533030]~~		<ref group="xtra">PMID:16533030</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	~~[[Category: Single protein]]~~
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
	[[Category: Glasfeld, A.]]		[[Category: Glasfeld, A.]]
Line 35:		Line 34:
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 16~~:04:~~34 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:53:41 2009''