2evf - Revision history

OCA at 07:40, 23 August 2023

2023-08-23T07:40:10Z

← Older revision		Revision as of 07:40, 23 August 2023
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	<StructureSection load='2evf' size='340' side='right'caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2evf' size='340' side='right'caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</div></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NDT80 ([https://www.ncbi.nlm~~.~~nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [https://pdbe.org/2evf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [https://www.ebi.ac.uk/pdbsum/2evf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [https://pdbe.org/2evf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [https://www.ebi.ac.uk/pdbsum/2evf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>		[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Glover, J N~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: ~~Lamoureux, J S~~]]		[[Category: Glover JN]]
	[[Category: ~~Beta-barrel]]~~		[[Category: Lamoureux JS]]
	~~[[Category: Cell cycle-dna complex]]~~
	~~[[Category: Ig-fold transcription factor~~]]

OCA at 12:31, 10 February 2021

2021-02-10T12:31:17Z

← Older revision		Revision as of 12:31, 10 February 2021
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	==Structure of a Ndt80-DNA complex (MSE mutant mA6T)==		==Structure of a Ndt80-DNA complex (MSE mutant mA6T)==
	<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2evf' size='340' side='right'caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EVF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [~~http~~://pdbe.org/2evf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2evf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2evf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [https://pdbe.org/2evf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [https://www.ebi.ac.uk/pdbsum/2evf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>		[[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Glover, J N]]		[[Category: Glover, J N]]
	[[Category: Lamoureux, J S]]		[[Category: Lamoureux, J S]]

OCA at 09:00, 14 June 2018

2018-06-14T09:00:50Z

← Older revision		Revision as of 09:00, 14 June 2018
Line 1:		Line 1:

	==Structure of a Ndt80-DNA complex (MSE mutant mA6T)==		==Structure of a Ndt80-DNA complex (MSE mutant mA6T)==
	<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://pdbe.org/2evf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://pdbe.org/2evf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2evf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2evf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:48, 11 September 2015

2015-09-11T10:48:08Z

← Older revision		Revision as of 10:48, 11 September 2015
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	<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://pdbe.org/2evf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2evf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Glover, J N]]		[[Category: Glover, J N]]
	[[Category: Lamoureux, J S]]		[[Category: Lamoureux, J S]]

OCA at 15:25, 25 December 2014

2014-12-25T15:25:47Z

← Older revision		Revision as of 15:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Glover, J N.]]		[[Category: Glover, J N]]
	[[Category: Lamoureux, J S.]]		[[Category: Lamoureux, J S]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Cell cycle-dna complex]]		[[Category: Cell cycle-dna complex]]
	[[Category: Ig-fold transcription factor]]		[[Category: Ig-fold transcription factor]]

OCA at 00:15, 30 September 2014

2014-09-30T00:15:54Z

← Older revision		Revision as of 00:15, 30 September 2014
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	[[Image:~~2evf~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of a Ndt80-DNA complex (MSE mutant mA6T)==
			<StructureSection load='2evf' size='340' side='right' caption='[[2evf]], [[Resolution\|resolution]] 1.56Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mnn\|1mnn]], [[1mn4\|1mn4]], [[1m6u\|1m6u]], [[1m7u\|1m7u]], [[2euv\|2euv]], [[2etw\|2etw]], [[2eux\|2eux]], [[2euz\|2euz]], [[2euw\|2euw]], [[2evg\|2evg]], [[2evh\|2evh]], [[2ehi\|2ehi]], [[2ehj\|2ehj]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evf RCSB], [http://www.ebi.ac.uk/pdbsum/2evf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Saccharomyces cerevisiae transcription factor Ndt80 selectively binds a DNA consensus sequence (the middle sporulation element [MSE]) to activate gene expression after the successful completion of meiotic recombination. Here we report the X-ray crystal structures of Ndt80 bound to ten distinct MSE variants. Comparison of these structures with the structure of Ndt80 bound to a consensus MSE reveals structural principles that determine the DNA binding specificity of this transcription factor. The 5' GC-rich end of the MSE contains distinct 5'-YpG-3' steps that are recognized by arginine side chains through a combination of hydrogen bonding and cation-pi interactions. The 3' AT-rich region is recognized via minor groove contacts that sterically exclude the N2 atom of GC base pairs. The conformation of the AT-rich region is fixed by interactions with the protein that favor recognition of poly(A)-poly(T) versus mixed AT sequences through an avoidance of major groove steric clashes at 5'-ApT-3' steps.

	~~{{STRUCTURE_2evf\| PDB=2evf \| SCENE= }}~~		Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes.,Lamoureux JS, Glover JN Structure. 2006 Mar;14(3):555-65. PMID:16531239<ref>PMID:16531239</ref>

	~~===Structure~~ of ~~a Ndt80-DNA complex (MSE mutant mA6T)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16531239}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2evf]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016531239<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Glover, J N.]]		[[Category: Glover, J N.]]

OCA: Protected "2evf" [edit=sysop:move=sysop]

2013-01-06T09:40:29Z

Protected "2evf" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:40, 6 January 2013
(No difference)

OCA at 09:40, 6 January 2013

2013-01-06T09:40:26Z

← Older revision		Revision as of 09:40, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2evf.png\|left\|200px]]		[[Image:2evf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2evf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2evf\| PDB=2evf \| SCENE= }}		{{STRUCTURE_2evf\| PDB=2evf \| SCENE= }}

	===Structure of a Ndt80-DNA complex (MSE mutant mA6T)===		===Structure of a Ndt80-DNA complex (MSE mutant mA6T)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16531239}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16531239 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16531239}}		{{ABSTRACT_PUBMED_16531239}}

	==About this Structure==		==About this Structure==
	~~2EVF~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA].		[[2evf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16531239~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016531239</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Glover, J N.]]		[[Category: Glover, J N.]]
	[[Category: Lamoureux, J S.]]		[[Category: Lamoureux, J S.]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
			[[Category: Cell cycle-dna complex]]
	[[Category: Ig-fold transcription factor]]		[[Category: Ig-fold transcription factor]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:16:55 2009''~~

OCA at 18:16, 17 February 2009

2009-02-17T18:16:57Z

← Older revision		Revision as of 18:16, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2EVF is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA].		2EVF is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVF OCA].

	==Reference==		==Reference==
	~~Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes., Lamoureux JS, Glover JN, Structure. 2006 Mar;14(3):555-65.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16531239 16531239]~~		<ref group="xtra">PMID:16531239</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	~~[[Category: Single protein]]~~
	[[Category: Glover, J N.]]		[[Category: Glover, J N.]]
	[[Category: Lamoureux, J S.]]		[[Category: Lamoureux, J S.]]
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	[[Category: Ig-fold transcription factor]]		[[Category: Ig-fold transcription factor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:09:~~17 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:16:55 2009''

OCA at 01:09, 29 July 2008

2008-07-29T01:09:22Z

← Older revision		Revision as of 01:09, 29 July 2008
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	[[Image:2evf.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2evf.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2evf\| PDB=2evf \| SCENE= }}		{{STRUCTURE_2evf\| PDB=2evf \| SCENE= }}

	~~'''~~Structure of a Ndt80-DNA complex (MSE mutant mA6T)~~'''~~		===Structure of a Ndt80-DNA complex (MSE mutant mA6T)===


	~~==Overview==~~		<!--
	The ~~Saccharomyces cerevisiae transcription factor Ndt80 selectively binds a DNA consensus sequence (~~the ~~middle sporulation element [MSE])~~ to ~~activate gene expression after~~ the ~~successful completion of meiotic recombination. Here we report the X-ray crystal structures of Ndt80 bound to ten distinct MSE variants~~. ~~Comparison of these structures with the structure of Ndt80 bound to a consensus MSE reveals structural principles that determine the DNA binding specificity of this transcription factor~~. ~~The 5' GC-rich end of the MSE contains distinct 5'-YpG-3' steps that are recognized by arginine side chains through a combination of hydrogen bonding and cation-pi interactions. The 3' AT-rich region~~ is ~~recognized via minor groove contacts that sterically exclude~~ the ~~N2 atom of GC base pairs~~. The conformation of the AT-rich region is fixed by interactions with the protein that favor recognition of poly(A)-poly(T) versus mixed AT sequences through an avoidance of major groove steric clashes at 5'-~~ApT~~-~~3' steps.~~		The line below this paragraph, {{ABSTRACT_PUBMED_16531239}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16531239 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16531239}}

	==About this Structure==		==About this Structure==
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	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Ig-fold transcription factor]]		[[Category: Ig-fold transcription factor]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 03~~:09:28 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:09:17 2008''