2ex2 - Revision history

OCA at 07:58, 30 October 2024

2024-10-30T07:58:01Z

← Older revision		Revision as of 07:58, 30 October 2024
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	<StructureSection load='2ex2' size='340' side='right'caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ex2' size='340' side='right'caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">dacB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [https://pdbe.org/2ex2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ex2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [https://pdbe.org/2ex2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ex2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>		[https://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kishida, H]]		[[Category: Kishida H]]
	[[Category: Lloyd, A]]		[[Category: Lloyd A]]
	[[Category: Park, S Y]]		[[Category: Park S-Y]]
	[[Category: Roper~~, D I~~]]		[[Category: Roper DI]]
	[[Category: Tame~~, J R.H~~]]		[[Category: Tame JRH]]
	[[Category: Unzai, S]]		[[Category: Unzai S]]
	~~[[Category: Cephem]]~~
	~~[[Category: D-alanyl-d-alanine-carboxypeptidase]]~~
	~~[[Category: D-alanyl-d-alanine-endopeptidase]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Penem]]~~
	~~[[Category: Penicillin]]~~
	~~[[Category: Penicillin-binding protein~~]]

OCA at 12:33, 10 February 2021

2021-02-10T12:33:04Z

← Older revision		Revision as of 12:33, 10 February 2021
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	==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli==		==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli==
	<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ex2' size='340' side='right'caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [~~http~~://pdbe.org/2ex2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ex2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [https://pdbe.org/2ex2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ex2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>		[[https://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Penicillin-binding protein\|Penicillin-binding protein]]		*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Kishida, H]]		[[Category: Kishida, H]]
	[[Category: Lloyd, A]]		[[Category: Lloyd, A]]

OCA at 08:33, 25 July 2018

2018-07-25T08:33:49Z

← Older revision		Revision as of 08:33, 25 July 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:58, 19 October 2016

2016-10-19T09:58:18Z

← Older revision		Revision as of 09:58, 19 October 2016
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	==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli==		==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli==
	<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://pdbe.org/2ex2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://pdbe.org/2ex2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:34, 8 February 2016

2016-02-08T08:34:33Z

← Older revision		Revision as of 08:34, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ex2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:46, 10 September 2015

2015-09-10T09:46:02Z

← Older revision		Revision as of 09:46, 10 September 2015
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	<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://pdbe.org/2ex2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ex2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Kishida, H]]		[[Category: Kishida, H]]
	[[Category: Lloyd, A]]		[[Category: Lloyd, A]]

OCA at 22:00, 24 December 2014

2014-12-24T22:00:34Z

← Older revision		Revision as of 22:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kishida, H.]]		[[Category: Kishida, H]]
	[[Category: Lloyd, A.]]		[[Category: Lloyd, A]]
	[[Category: Park, S Y.]]		[[Category: Park, S Y]]
	[[Category: Roper, D I.]]		[[Category: Roper, D I]]
	[[Category: Tame, J R.H.]]		[[Category: Tame, J R.H]]
	[[Category: Unzai, S.]]		[[Category: Unzai, S]]
	[[Category: Cephem]]		[[Category: Cephem]]
	[[Category: D-alanyl-d-alanine-carboxypeptidase]]		[[Category: D-alanyl-d-alanine-carboxypeptidase]]

OCA at 04:27, 3 October 2014

2014-10-03T04:27:55Z

← Older revision		Revision as of 04:27, 3 October 2014
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	~~{{STRUCTURE_2ex2~~\| ~~PDB~~=2ex2 \| ~~SCENE~~= }}		==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli==
	===~~Crystal~~ structure of penicillin binding protein 4 (~~dacB~~) from Escherichia coli~~===~~		<StructureSection load='2ex2' size='340' side='right' caption='[[2ex2]], [[Resolution\|resolution]] 1.55Å' scene=''>
	~~{{ABSTRACT_PUBMED_16411754}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EX2 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ex6\|2ex6]], [[2ex8\|2ex8]], [[2ex9\|2ex9]], [[2exa\|2exa]], [[2exb\|2exb]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dacB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ex2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ex2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ex2 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of penicillin binding protein 4 (PBP4) from Escherichia coli, which has both DD-endopeptidase and DD-carboxypeptidase activity, is presented. PBP4 is one of 12 penicillin binding proteins in E. coli involved in the synthesis and maintenance of the cell wall. The model contains a penicillin binding domain similar to known structures, but includes a large insertion which folds into domains with unique folds. The structures of the protein covalently attached to five different antibiotics presented here show the active site residues are unmoved compared to the apoprotein, but nearby surface loops and helices are displaced in some cases. The altered geometry of conserved active site residues compared with those of other PBPs suggests a possible cause for the slow deacylation rate of PBP4.

	~~==Function==~~		Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics.,Kishida H, Unzai S, Roper DI, Lloyd A, Park SY, Tame JR Biochemistry. 2006 Jan 24;45(3):783-92. PMID:16411754<ref>PMID:16411754</ref>
	~~[[http://www~~.~~uniprot~~.~~org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD~~-~~endopeptidase reaction~~.<ref>PMID:~~2046551~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2ex2]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:016411754</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Penicillin-binding protein\|Penicillin-binding protein]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kishida, H.]]		[[Category: Kishida, H.]]

OCA at 08:01, 30 June 2013

2013-06-30T08:01:25Z

← Older revision		Revision as of 08:01, 30 June 2013
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	~~[[Image:2ex2.png\|left\|200px]]~~

	{{STRUCTURE_2ex2\| PDB=2ex2 \| SCENE= }}		{{STRUCTURE_2ex2\| PDB=2ex2 \| SCENE= }}

	===Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli===		===Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli===
			{{ABSTRACT_PUBMED_16411754}}

	~~{{ABSTRACT_PUBMED_16411754}}~~		==Function==
			[[http://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>

	==About this Structure==		==About this Structure==
	[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA].		[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA].

	~~==See Also==~~
	*[[Penicillin-binding protein\|Penicillin-binding protein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:016411754</ref><references group="xtra"/>		<ref group="xtra">PMID:016411754</ref><references group="xtra"/><references/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kishida, H.]]		[[Category: Kishida, H.]]

OCA at 09:33, 20 October 2012

2012-10-20T09:33:59Z

← Older revision		Revision as of 09:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2ex2]] is a 1 chain structure ~~of [[Penicillin-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA].		[[2ex2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX2 OCA].

	==See Also==		==See Also==