2eyn - Revision history

OCA at 07:40, 23 August 2023

2023-08-23T07:40:52Z

← Older revision		Revision as of 07:40, 23 August 2023
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	<StructureSection load='2eyn' size='340' side='right'caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eyn' size='340' side='right'caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2eyi\|2eyi]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ACTN1 ([https://www.ncbi.nlm~~.~~nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [https://pdbe.org/2eyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [https://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [https://pdbe.org/2eyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [https://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.		[https://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Borrego-Diaz, E]]		[[Category: Borrego-Diaz E]]
	[[Category: Dominguez, R]]		[[Category: Dominguez R]]
	[[Category: Ferron, F]]		[[Category: Ferron F]]
	[[Category: Kerff, F]]		[[Category: Kerff F]]
	[[Category: Lee~~, S H~~]]		[[Category: Lee SH]]
	[[Category: Li, Y]]		[[Category: Li Y]]
	~~[[Category: Actin-binding]]~~
	~~[[Category: Actin-bundling]]~~
	~~[[Category: Actin-crosslinking]]~~
	~~[[Category: Calponin homology domain]]~~
	~~[[Category: Ch domain]]~~
	~~[[Category: Structural protein~~]]

OCA at 12:34, 10 February 2021

2021-02-10T12:34:57Z

← Older revision		Revision as of 12:34, 10 February 2021
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	==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==		==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==
	<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eyn' size='340' side='right'caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2eyi\|2eyi]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [~~http~~://pdbe.org/2eyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [https://pdbe.org/2eyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [https://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.		[[https://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyn_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Actinin 3D structures\|Actinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Borrego-Diaz, E]]		[[Category: Borrego-Diaz, E]]
	[[Category: Dominguez, R]]		[[Category: Dominguez, R]]

OCA at 07:31, 18 October 2017

2017-10-18T07:31:02Z

← Older revision		Revision as of 07:31, 18 October 2017
Line 1:		Line 1:

	==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==		==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==
	<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://pdbe.org/2eyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://pdbe.org/2eyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eyn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Actinin\|Actinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:41, 12 September 2015

2015-09-12T02:41:46Z

← Older revision		Revision as of 02:41, 12 September 2015
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	<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://pdbe.org/2eyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Borrego-Diaz, E]]		[[Category: Borrego-Diaz, E]]
	[[Category: Dominguez, R]]		[[Category: Dominguez, R]]

OCA at 22:51, 25 December 2014

2014-12-25T22:51:10Z

← Older revision		Revision as of 22:51, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Borrego-Diaz, E.]]		[[Category: Borrego-Diaz, E]]
	[[Category: Dominguez, R.]]		[[Category: Dominguez, R]]
	[[Category: Ferron, F.]]		[[Category: Ferron, F]]
	[[Category: Kerff, F.]]		[[Category: Kerff, F]]
	[[Category: Lee, S H.]]		[[Category: Lee, S H]]
	[[Category: Li, Y.]]		[[Category: Li, Y]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Actin-bundling]]		[[Category: Actin-bundling]]

OCA at 10:32, 29 September 2014

2014-09-29T10:32:03Z

← Older revision		Revision as of 10:32, 29 September 2014
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	[[Image:~~2eyn~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==
			<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eyi\|2eyi]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyn_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Alpha-actinin belongs to the spectrin family of actin crosslinking and bundling proteins that function as key regulators of cell motility, morphology and adhesion. The actin-binding domain (ABD) of these proteins consists of two consecutive calponin homology (CH) domains. Electron microscopy studies on ABDs appear to support two competing actin-binding models, extended and compact, whereas the crystal structures typically display a compact conformation. We have determined the 1.7A resolution structure of the ABD of alpha-actinin 1, a ubiquitously expressed isoform. The structure displays the classical compact conformation. We evaluated the two binding models by surface conservation analysis. The results show a conserved surface that spans both domains and corresponds to two previously identified actin-binding sites (ABS2 and ABS3). A third, and probably less important site, ABS1, is mostly buried in the compact conformation. However, a thorough examination of existing structures suggests a weak and semi-polar binding interface between the two CHs, leaving open the possibility of domain reorientation or opening. Our results are consistent with a two-step binding mechanism in which the ABD interacts first in the compact form observed in the structures, and then transitions toward a higher affinity state, possibly through minor rearrangement of the domains.

	~~{{STRUCTURE_2eyn\| PDB=2eyn \| SCENE= }}~~		Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models.,Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R J Struct Biol. 2006 Aug;155(2):230-8. Epub 2006 Apr 25. PMID:16698282<ref>PMID:16698282</ref>

	~~===Crystal structure~~ of the ~~actin-binding domain~~ of ~~human alpha-actinin 1 at 1~~.~~8 Angstrom resolution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16698282}}~~

	~~==About this Structure==~~
	~~[[2eyn]] is a 1 chain structure with sequence from [http:/~~/~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].~~

	==See Also==		==See Also==
	*[[Actinin\|Actinin]]		*[[Actinin\|Actinin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016698282<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Borrego-Diaz, E.]]		[[Category: Borrego-Diaz, E.]]

OCA at 22:36, 20 October 2012

2012-10-20T22:36:15Z

← Older revision		Revision as of 22:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2eyn]] is a 1 chain structure ~~of [[Actinin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].		[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].

	==See Also==		==See Also==

OCA: Protected "2eyn" [edit=sysop:move=sysop]

2012-07-27T16:52:26Z

Protected "2eyn" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:52, 27 July 2012
(No difference)

OCA at 16:52, 27 July 2012

2012-07-27T16:52:25Z

← Older revision		Revision as of 16:52, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2eyn.png\|left\|200px]]		[[Image:2eyn.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2eyn", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2eyn\| PDB=2eyn \| SCENE= }}		{{STRUCTURE_2eyn\| PDB=2eyn \| SCENE= }}

	===Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution===		===Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16698282}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16698282 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16698282}}		{{ABSTRACT_PUBMED_16698282}}

	==About this Structure==		==About this Structure==
	~~2EYN~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].		[[2eyn]] is a 1 chain structure of [[Actinin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].

			==See Also==
			*[[Actinin\|Actinin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16698282~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016698282</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Borrego-Diaz, E.]]		[[Category: Borrego-Diaz, E.]]
Line 37:		Line 28:
	[[Category: Ch domain]]		[[Category: Ch domain]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:11:50 2009''~~

OCA at 08:11, 18 February 2009

2009-02-18T08:11:51Z

← Older revision		Revision as of 08:11, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2EYN is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].		2EYN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA].

	==Reference==		==Reference==
	Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models., Borrego-Diaz E, Kerff F, Lee SH, Ferron F, Li Y, Dominguez R, J Struct Biol. 2006 Aug;155(2):230-8. Epub 2006 Apr 25. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16698282 16698282]~~		<ref group="xtra">PMID:16698282</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Borrego-Diaz, E.]]		[[Category: Borrego-Diaz, E.]]
	[[Category: Dominguez, R.]]		[[Category: Dominguez, R.]]
Line 39:		Line 38:
	[[Category: Structural protein]]		[[Category: Structural protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:38:~~00 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:11:50 2009''