2f2f - Revision history

OCA at 05:11, 17 October 2024

2024-10-17T05:11:55Z

← Older revision		Revision as of 05:11, 17 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:41, 23 August 2023

2023-08-23T07:41:53Z

← Older revision		Revision as of 07:41, 23 August 2023
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	<StructureSection load='2f2f' size='340' side='right'caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f2f' size='340' side='right'caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>cdtA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~714~~ "~~Bacterium acetinomycetum comitans~~" ~~(sic) (Klinger 1912) Colebrook 1920])~~, ~~cdtB (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920~~]~~), cdtC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [https://pdbe.org/2f2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [https://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [https://pdbe.org/2f2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [https://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>		[https://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Aggregatibacter actinomycetemcomitans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Komoto, J]]		[[Category: Komoto J]]
	[[Category: Konishi, K]]		[[Category: Konishi K]]
	[[Category: Saiki, K]]		[[Category: Saiki K]]
	[[Category: Takusagawa, F]]		[[Category: Takusagawa F]]
	[[Category: Yamada, T]]		[[Category: Yamada T]]
	~~[[Category: Actinobacillus actinomycetemcomitan]]~~
	~~[[Category: Cdt]]~~
	~~[[Category: Cytolethal distending toxin]]~~
	~~[[Category: Oligomerization]]~~
	~~[[Category: Stability and toxic activity]]~~
	~~[[Category: Toxin~~]]

OCA at 10:37, 17 February 2021

2021-02-17T10:37:01Z

← Older revision		Revision as of 10:37, 17 February 2021
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	==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==		==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==
	<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f2f' size='340' side='right'caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [~~http~~://pdbe.org/2f2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [https://pdbe.org/2f2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [https://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>		[[https://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Komoto, J]]		[[Category: Komoto, J]]
	[[Category: Konishi, K]]		[[Category: Konishi, K]]

OCA at 07:32, 18 October 2017

2017-10-18T07:32:43Z

← Older revision		Revision as of 07:32, 18 October 2017
Line 1:		Line 1:

	==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==		==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==
	<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://pdbe.org/2f2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://pdbe.org/2f2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f2f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:56, 11 September 2015

2015-09-11T15:56:44Z

← Older revision		Revision as of 15:56, 11 September 2015
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	<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_acetinomycetum_comitans"_(sic)_(klinger_1912)_colebrook_1920 "bacterium acetinomycetum comitans" (sic) (klinger 1912) colebrook 1920]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 ~~Aggregatibacter actinomycetemcomitans~~]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 ~~Aggregatibacter actinomycetemcomitans~~]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 ~~Aggregatibacter actinomycetemcomitans~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 "Bacterium acetinomycetum comitans" (sic) (Klinger 1912) Colebrook 1920])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://pdbe.org/2f2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~CDTA_ACTAC CDTA_ACTAC~~]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>		[[http://www.uniprot.org/uniprot/CDTA_AGGAC CDTA_AGGAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2f2f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Aggregatibacter actinomycetemcomitans]]~~
	[[Category: Komoto, J]]		[[Category: Komoto, J]]
	[[Category: Konishi, K]]		[[Category: Konishi, K]]

OCA at 18:41, 25 December 2014

2014-12-25T18:41:24Z

← Older revision		Revision as of 18:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CDTA_ACTAC CDTA_ACTAC]] CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.<ref>PMID:16434747</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Aggregatibacter actinomycetemcomitans]]		[[Category: Aggregatibacter actinomycetemcomitans]]
	[[Category: Komoto, J.]]		[[Category: Komoto, J]]
	[[Category: Konishi, K.]]		[[Category: Konishi, K]]
	[[Category: Saiki, K.]]		[[Category: Saiki, K]]
	[[Category: Takusagawa, F.]]		[[Category: Takusagawa, F]]
	[[Category: Yamada, T.]]		[[Category: Yamada, T]]
	[[Category: Actinobacillus actinomycetemcomitan]]		[[Category: Actinobacillus actinomycetemcomitan]]
	[[Category: Cdt]]		[[Category: Cdt]]

OCA at 02:33, 30 September 2014

2014-09-30T02:33:07Z

← Older revision		Revision as of 02:33, 30 September 2014
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	[[Image:~~2f2f~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans==
			<StructureSection load='2f2f' size='340' side='right' caption='[[2f2f]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2F FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdtA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans]), cdtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f2f RCSB], [http://www.ebi.ac.uk/pdbsum/2f2f PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2f_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cytolethal distending toxin (CDT) secreted by Actinobacillus actinomycetemcomitans induces cell cycle arrest of cultured cells in the G2 phase. The crystal structure of the natural form of A. actinomycetemcomitans DCT (aCDT) has been determined at 2.4 A resolution. aCDT is a heterotrimer consisting of the three subunits, aCdtA, aCdtB, and aCdtC. Two crystallographically independent aCDTs form a dimer through interactions of the aCdtB subunits. The primary structure of aCDT has 94.3% identity with that of Haemophilus ducreyi CDT (hCDT), and the structure of aCDT is quite similar to that of hCDT reconstituted from the three subunits determined recently. However, the molecular packings in the crystal structures of aCDT and hCDT are quite different. A careful analysis of molecular packing suggests that variation of the amino acid residues in a nonconserved loop (181TSSPSSPERRGY192 of aCdtB and 181NSSSSPPERRVY192 of hCdtB) is responsible for the different oligomerization of very similar CDTs. The loop of aCdtB has a conformation to form a dimer, while the loop conformation of hCdtB prevents hCDT from forming a dimer. Although dimerization of aCDT does not affect toxic activity, it changes the stability of protein. aCDT rapidly aggregates and loses toxic activity in the absence of sucrose in a buffered solution, while hCDT is stable and retains toxic activity. Another analysis of crystal structures of aCDT and hCDT suggests that the receptor contact area is in the deep groove between CdtA and CdtC, and the characteristic "aromatic patch" on CdtA.

	~~{{STRUCTURE_2f2f\| PDB=2f2f \| SCENE= }}~~		Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans.,Yamada T, Komoto J, Saiki K, Konishi K, Takusagawa F Protein Sci. 2006 Feb;15(2):362-72. PMID:16434747<ref>PMID:16434747</ref>

	~~===Crystal structure~~ of ~~cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16434747}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2f2f]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016434747<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Aggregatibacter actinomycetemcomitans]]		[[Category: Aggregatibacter actinomycetemcomitans]]
	[[Category: Komoto, J.]]		[[Category: Komoto, J.]]

OCA: Protected "2f2f" [edit=sysop:move=sysop]

2013-01-07T14:58:36Z

Protected "2f2f" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:58, 7 January 2013
(No difference)

OCA at 14:58, 7 January 2013

2013-01-07T14:58:33Z

← Older revision		Revision as of 14:58, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2f2f.png\|left\|200px]]		[[Image:2f2f.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2f2f", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2f2f\| PDB=2f2f \| SCENE= }}		{{STRUCTURE_2f2f\| PDB=2f2f \| SCENE= }}

	===Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans===		===Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16434747}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16434747 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16434747}}		{{ABSTRACT_PUBMED_16434747}}

	==About this Structure==		==About this Structure==
	~~2F2F~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA].		[[2f2f]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16434747~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016434747</ref><references group="xtra"/>
	[[Category: Aggregatibacter actinomycetemcomitans]]		[[Category: Aggregatibacter actinomycetemcomitans]]
	[[Category: Komoto, J.]]		[[Category: Komoto, J.]]
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	[[Category: Actinobacillus actinomycetemcomitan]]		[[Category: Actinobacillus actinomycetemcomitan]]
	[[Category: Cdt]]		[[Category: Cdt]]
	~~[[Category: Crystal structure]]~~
	[[Category: Cytolethal distending toxin]]		[[Category: Cytolethal distending toxin]]
	[[Category: Oligomerization]]		[[Category: Oligomerization]]
	[[Category: Stability and toxic activity]]		[[Category: Stability and toxic activity]]
			[[Category: Toxin]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 02:48:53 2009''~~

OCA at 00:48, 18 February 2009

2009-02-18T00:48:54Z

← Older revision		Revision as of 00:48, 18 February 2009
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	==About this Structure==		==About this Structure==
	2F2F is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA].		2F2F is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2F OCA].

	==Reference==		==Reference==
	Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans., Yamada T, Komoto J, Saiki K, Konishi K, Takusagawa F, Protein Sci. 2006 Feb;15(2):362-72. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16434747 16434747]~~		<ref group="xtra">PMID:16434747</ref><references group="xtra"/>
	[[Category: Aggregatibacter actinomycetemcomitans]]		[[Category: Aggregatibacter actinomycetemcomitans]]
	~~[[Category: Protein complex]]~~
	[[Category: Komoto, J.]]		[[Category: Komoto, J.]]
	[[Category: Konishi, K.]]		[[Category: Konishi, K.]]
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	[[Category: Stability and toxic activity]]		[[Category: Stability and toxic activity]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:29:~~10 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:48:53 2009''