2f3a - Revision history

OCA at 00:54, 21 November 2024

2024-11-21T00:54:40Z

← Older revision		Revision as of 00:54, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 5 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [https://pdbe.org/2f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [https://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [https://pdbe.org/2f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [https://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>

OCA at 12:37, 10 January 2024

2024-01-10T12:37:14Z

← Older revision		Revision as of 12:37, 10 January 2024
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	==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==		==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==
	<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a~~]], [[NMR_Ensembles_of_Models \| 5 NMR models~~]]' scene=''>		<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1vm5\|1vm5]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [https://pdbe.org/2f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [https://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [https://pdbe.org/2f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [https://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Li, X~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Peterkofsky, A~~]]		[[Category: Li X]]
	[[Category: ~~Wang, G~~]]		[[Category: Peterkofsky A]]
	[[Category: ~~Antimicrobial peptide]]~~		[[Category: Wang G]]
	~~[[Category: Antimicrobial protein]]~~
	~~[[Category: Aurein 1 2]]~~
	~~[[Category: Ll-37]]~~
	~~[[Category: Llaa~~]]

OCA at 10:54, 6 April 2022

2022-04-06T10:54:25Z

← Older revision		Revision as of 10:54, 6 April 2022
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	<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>		<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vm5\|1vm5]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [~~http~~://pdbe.org/2f3a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [https://pdbe.org/2f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [https://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:38, 25 June 2020

2020-06-25T06:38:16Z

← Older revision		Revision as of 06:38, 25 June 2020
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	<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>		<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F3A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://pdbe.org/2f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://pdbe.org/2f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:45, 18 March 2020

2020-03-18T10:45:05Z

← Older revision		Revision as of 10:45, 18 March 2020
Line 1:		Line 1:

	==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==		==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==
	<StructureSection load='2f3a' size='340' side='right' caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>		<StructureSection load='2f3a' size='340' side='right'caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F3A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Li, X]]		[[Category: Li, X]]
	[[Category: Peterkofsky, A]]		[[Category: Peterkofsky, A]]

OCA at 09:04, 14 June 2018

2018-06-14T09:04:48Z

← Older revision		Revision as of 09:04, 14 June 2018
Line 1:		Line 1:

	==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==		==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==
	<StructureSection load='2f3a' size='340' side='right' caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>		<StructureSection load='2f3a' size='340' side='right' caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://pdbe.org/2f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://pdbe.org/2f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:23, 11 September 2015

2015-09-11T03:23:16Z

← Older revision		Revision as of 03:23, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://pdbe.org/2f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2f3a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:48, 15 January 2015

2015-01-15T16:48:44Z

← Older revision		Revision as of 16:48, 15 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Li, X.]]		[[Category: Li, X]]
	[[Category: Peterkofsky, A.]]		[[Category: Peterkofsky, A]]
	[[Category: Wang, G.]]		[[Category: Wang, G]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 15:29, 12 October 2014

2014-10-12T15:29:00Z

← Older revision		Revision as of 15:29, 12 October 2014
Line 1:		Line 1:
	[[~~Image~~:~~2f3a~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles==
			<StructureSection load='2f3a' size='340' side='right' caption='[[2f3a]], [[NMR_Ensembles_of_Models \| 5 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2f3a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F3A FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vm5\|1vm5]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f3a RCSB], [http://www.ebi.ac.uk/pdbsum/2f3a PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aurein 1.2 is an antimicrobial and anticancer peptide isolated from an Australian frog. To improve our understanding of the mechanism of action, two series of peptides were designed. The first series includes the N-terminal membrane anchor of bacterial glucose-specific enzyme IIA, aurein 1.2, and a newly identified aurein 1.2 analog from human LL-37 (LLAA). The order of antibacterial activity is LLAA>aurein 1.2>>the membrane anchor (inactive). The structure of LLAA in detergent micelles was determined by (1)H NMR spectroscopy, including structural refinement by natural abundance (13)C(alpha), (13)C(beta), and (15)N chemical shifts. The hydrophobic surface area of the 3D structure is related to the retention time of the peptide on a reverse-phase HPLC column. The higher activity of LLAA compared to aurein 1.2 was attributed to additional cationic residues that enhance the membrane perturbation potential. The second peptide series was created by changing the C-terminal phenylalanine (F13) of aurein 1.2 to either phenylglycine or tryptophan. A closer or further location of the aromatic rings to the peptide backbone in the mutants relative to F13 is proposed to cause a drop in activity. Phenylglycine with unique chemical shifts may be a useful NMR probe for structure-activity relationship studies of antimicrobial peptides. To facilitate potential future use for NMR studies, random-coil chemical shifts for phenylglycine (X) were measured using the synthetic peptide GGXGG. Aromatic rings of phenylalanines in all the peptides penetrated 2-5 A below the lipid head group and are essential for membrane targeting as illustrated by intermolecular peptide-lipid NOE patterns.

	~~{{STRUCTURE_2f3a\| PDB=2f3a \| SCENE= }}~~		NMR studies of aurein 1.2 analogs.,Li X, Li Y, Peterkofsky A, Wang G Biochim Biophys Acta. 2006 Sep;1758(9):1203-14. Epub 2006 Apr 7. PMID:16716252<ref>PMID:16716252</ref>

	~~===Solution structure~~ of the ~~LL-37-derived aurein 1~~.~~2 analog (LLAA) in membrane-mimetic micelles===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16716252}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2f3a]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2F3A OCA].~~		</StructureSection>
	[[Category: Li, X.]]		[[Category: Li, X.]]
	[[Category: Peterkofsky, A.]]		[[Category: Peterkofsky, A.]]

OCA: Protected "2f3a" [edit=sysop:move=sysop]

2013-01-07T14:31:18Z

Protected "2f3a" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:31, 7 January 2013
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