2fa3 - Revision history

OCA at 07:58, 30 October 2024

2024-10-30T07:58:52Z

← Older revision		Revision as of 07:58, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa3_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:24, 30 August 2023

2023-08-30T09:24:08Z

← Older revision		Revision as of 09:24, 30 August 2023
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	<StructureSection load='2fa3' size='340' side='right'caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2fa3' size='340' side='right'caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Braju Braju~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SCY~~:S-ACETYL~~-CYSTEINE~~'>~~SCY~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]~~</~~div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [https://pdbe.org/2fa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [https://pdbe.org/2fa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa3 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9M6U3_BRAJU Q9M6U3_BRAJU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Braju~~]]		[[Category: Brassica juncea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ferrer~~, J L~~]]		[[Category: Ferrer JL]]
	[[Category: Noel~~, J P~~]]		[[Category: Noel JP]]
	[[Category: Pojer, F]]		[[Category: Pojer F]]
	[[Category: Richard~~, S B]]~~		[[Category: Richard SB]]
	~~[[Category: Acetyl-coa]]~~
	~~[[Category: Hmgs1]]~~
	~~[[Category: Transferase~~]]

OCA at 16:02, 22 December 2021

2021-12-22T16:02:36Z

← Older revision		Revision as of 16:02, 22 December 2021
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	<StructureSection load='2fa3' size='340' side='right'caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2fa3' size='340' side='right'caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Braju Braju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Braju Braju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [~~http~~://pdbe.org/2fa3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fa3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [https://pdbe.org/2fa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:47, 18 March 2020

2020-03-18T10:47:24Z

← Older revision		Revision as of 10:47, 18 March 2020
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	==HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.==		==HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.==
	<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2fa3' size='340' side='right'caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Braju Braju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Braju Braju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Braju]]		[[Category: Braju]]
			[[Category: Large Structures]]
	[[Category: Ferrer, J L]]		[[Category: Ferrer, J L]]
	[[Category: Noel, J P]]		[[Category: Noel, J P]]

OCA at 09:15, 14 June 2018

2018-06-14T09:15:42Z

← Older revision		Revision as of 09:15, 14 June 2018
Line 1:		Line 1:

	==HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.==		==HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.==
	<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://pdbe.org/2fa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://pdbe.org/2fa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa3_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:33, 8 February 2016

2016-02-08T15:33:06Z

← Older revision		Revision as of 15:33, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fa3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:59, 10 September 2015

2015-09-10T12:59:32Z

← Older revision		Revision as of 12:59, 10 September 2015
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	<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Brassica_juncea Brassica juncea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Braju Braju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://pdbe.org/2fa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fa3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Brassica juncea~~]]		[[Category: Braju]]
	[[Category: Ferrer, J L]]		[[Category: Ferrer, J L]]
	[[Category: Noel, J P]]		[[Category: Noel, J P]]

OCA at 09:24, 16 January 2015

2015-01-16T09:24:41Z

← Older revision		Revision as of 09:24, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Brassica juncea]]		[[Category: Brassica juncea]]
	[[Category: Ferrer, J L.]]		[[Category: Ferrer, J L]]
	[[Category: Noel, J P.]]		[[Category: Noel, J P]]
	[[Category: Pojer, F.]]		[[Category: Pojer, F]]
	[[Category: Richard, S B.]]		[[Category: Richard, S B]]
	[[Category: Acetyl-coa]]		[[Category: Acetyl-coa]]
	[[Category: Hmgs1]]		[[Category: Hmgs1]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 02:59, 30 September 2014

2014-09-30T02:59:59Z

← Older revision		Revision as of 02:59, 30 September 2014
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	[[Image:~~2fa3~~.~~png~~\|~~left~~\|~~200px~~]]		==HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.==
			<StructureSection load='2fa3' size='340' side='right' caption='[[2fa3]], [[Resolution\|resolution]] 2.52Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FA3 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f82\|2f82]], [[2f9a\|2f9a]], [[2fa0\|2fa0]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fa3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fa3 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa3_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.

	~~{{STRUCTURE_2fa3\| PDB=2fa3 \| SCENE= }}~~		Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.,Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776<ref>PMID:16864776</ref>

	~~===HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16864776}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fa3]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Brassica_juncea Brassica juncea]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FA3 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016864776<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Brassica juncea]]		[[Category: Brassica juncea]]
	[[Category: Ferrer, J L.]]		[[Category: Ferrer, J L.]]

OCA: Protected "2fa3" [edit=sysop:move=sysop]

2013-01-07T12:39:07Z

Protected "2fa3" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:39, 7 January 2013
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