2fce - Revision history

OCA at 18:56, 29 May 2024

2024-05-29T18:56:16Z

← Older revision		Revision as of 18:56, 29 May 2024
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	==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==		==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==
	<StructureSection load='2fce' size='340' side='right'caption='[[2fce~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2fce' size='340' side='right'caption='[[2fce]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MLC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4932 ATCC 18824])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [https://pdbe.org/2fce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [https://www.ebi.ac.uk/pdbsum/2fce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fce ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [https://pdbe.org/2fce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [https://www.ebi.ac.uk/pdbsum/2fce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST]] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>		[https://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cicero~~, D O~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Contessa~~, G M~~]]		[[Category: Cicero DO]]
	[[Category: Melino, S]]		[[Category: Contessa GM]]
	[[Category: Paci, M]]		[[Category: Melino S]]
	[[Category: Pennestri, M]]		[[Category: Paci M]]
	[[Category: Ragnini-Wilson, A]]		[[Category: Pennestri M]]
	~~[[Category: Cell cycle]]~~		[[Category: Ragnini-Wilson A]]
	~~[[Category: Ef-hand protein~~]]

OCA at 07:14, 24 February 2021

2021-02-24T07:14:48Z

← Older revision		Revision as of 07:14, 24 February 2021
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	==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==		==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==
	<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fce' size='340' side='right'caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [~~http~~://pdbe.org/2fce PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fce PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fce ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [https://pdbe.org/2fce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [https://www.ebi.ac.uk/pdbsum/2fce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST]] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>		[[https://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST]] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Cicero, D O]]		[[Category: Cicero, D O]]
	[[Category: Contessa, G M]]		[[Category: Contessa, G M]]

OCA at 09:27, 14 June 2018

2018-06-14T09:27:16Z

← Older revision		Revision as of 09:27, 14 June 2018
Line 1:		Line 1:

	==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==		==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==
	<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://pdbe.org/2fce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://pdbe.org/2fce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fce_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fce_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:32, 9 February 2016

2016-02-09T10:32:00Z

← Older revision		Revision as of 10:32, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fce ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:24, 10 September 2015

2015-09-10T21:24:17Z

← Older revision		Revision as of 21:24, 10 September 2015
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	<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://pdbe.org/2fce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fce" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Cicero, D O]]		[[Category: Cicero, D O]]
	[[Category: Contessa, G M]]		[[Category: Contessa, G M]]

OCA at 06:17, 25 December 2014

2014-12-25T06:17:15Z

← Older revision		Revision as of 06:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MLC1_YEAST MLC1_YEAST]] Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.<ref>PMID:9700160</ref> <ref>PMID:12456647</ref> <ref>PMID:15210731</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cicero, D O.]]		[[Category: Cicero, D O]]
	[[Category: Contessa, G M.]]		[[Category: Contessa, G M]]
	[[Category: Melino, S.]]		[[Category: Melino, S]]
	[[Category: Paci, M.]]		[[Category: Paci, M]]
	[[Category: Pennestri, M.]]		[[Category: Pennestri, M]]
	[[Category: Ragnini-Wilson, A.]]		[[Category: Ragnini-Wilson, A]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Ef-hand protein]]		[[Category: Ef-hand protein]]

OCA at 09:25, 29 September 2014

2014-09-29T09:25:27Z

← Older revision		Revision as of 09:25, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2fce~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae==
			<StructureSection load='2fce' size='340' side='right' caption='[[2fce]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCE FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fce RCSB], [http://www.ebi.ac.uk/pdbsum/2fce PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fce_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Calmodulin, regulatory, and essential myosin light chain are evolutionary conserved proteins that, by binding to IQ motifs of target proteins, regulate essential intracellular processes among which are efficiency of secretory vesicles release at synapsis, intracellular signaling, and regulation of cell division. The yeast Saccharomyces cerevisiae calmodulin Cmd1 and the essential myosin light chain Mlc1p share the ability to interact with the class V myosin Myo2p and Myo4 and the class II myosin Myo1p. These myosins are required for vesicle, organelle, and mRNA transport, spindle orientation, and cytokinesis. We have used the budding yeast model system to study how calmodulin and essential myosin light chain selectively regulate class V myosin function. NMR structural analysis of uncomplexed Mlc1p and interaction studies with the first three IQ motifs of Myo2p show that the structural similarities between Mlc1p and the other members of the EF-hand superfamily of calmodulin-like proteins are mainly restricted to the C-lobe of these proteins. The N-lobe of Mlc1p presents a significantly compact and stable structure that is maintained both in the free and complexed states. The Mlc1p N-lobe interacts with the IQ motif in a manner that is regulated both by the IQ motifs sequence as well as by light chain structural features. These characteristic allows a distinctive interaction of Mlc1p with the first IQ motif of Myo2p when compared with calmodulin. This finding gives us a novel view of how calmodulin and essential light chain, through a differential binding to IQ1 of class V myosin motor, regulate this activity during vegetative growth and cytokinesis.

	~~{{STRUCTURE_2fce\| PDB=2fce \| SCENE= }}~~		Structural basis for the interaction of the myosin light chain Mlc1p with the myosin V Myo2p IQ motifs.,Pennestri M, Melino S, Contessa GM, Casavola EC, Paci M, Ragnini-Wilson A, Cicero DO J Biol Chem. 2007 Jan 5;282(1):667-79. Epub 2006 Oct 29. PMID:17074768<ref>PMID:17074768</ref>

	~~===Solution structure~~ of ~~C-lobe Myosin Light Chain from Saccharomices cerevisiae===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17074768}}~~

	~~==About this Structure==~~
	~~[[2fce]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2FCE OCA].~~

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017074768<~~/~~ref~~><~~ref group="xtra">PMID:018975975</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cicero, D O.]]		[[Category: Cicero, D O.]]

OCA at 13:35, 20 October 2012

2012-10-20T13:35:09Z

← Older revision		Revision as of 13:35, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2fce]] is a 1 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA].		[[2fce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA].

	==See Also==		==See Also==

OCA: Protected "2fce" [edit=sysop:move=sysop]

2012-07-26T12:26:41Z

Protected "2fce" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:26, 26 July 2012
(No difference)

OCA at 12:26, 26 July 2012

2012-07-26T12:26:40Z

← Older revision		Revision as of 12:26, 26 July 2012
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	~~{{Seed}}~~
	[[Image:2fce.png\|left\|200px]]		[[Image:2fce.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fce", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fce\| PDB=2fce \| SCENE= }}		{{STRUCTURE_2fce\| PDB=2fce \| SCENE= }}

	===Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae===		===Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17074768}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17074768 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17074768}}		{{ABSTRACT_PUBMED_17074768}}

	==About this Structure==		==About this Structure==
	~~2FCE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA].		[[2fce]] is a 1 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCE OCA].

			==See Also==
			*[[Myosin\|Myosin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17074768~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017074768</ref><ref group="xtra">PMID:018975975</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cicero, D O.]]		[[Category: Cicero, D O.]]
Line 33:		Line 24:
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Ef-hand protein]]		[[Category: Ef-hand protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 8 20:12:57 2009''~~