2fcf - Revision history

OCA at 09:24, 30 August 2023

2023-08-30T09:24:52Z

← Older revision		Revision as of 09:24, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2fcf' size='340' side='right'caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='2fcf' size='340' side='right'caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MPDZ~~, ~~MUPP1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.76Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [https://pdbe.org/2fcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [https://www.ebi.ac.uk/pdbsum/2fcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [https://pdbe.org/2fcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [https://www.ebi.ac.uk/pdbsum/2fcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>		[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith C]]
	[[Category: Berridge, G]]		[[Category: Berridge G]]
	[[Category: Bray, J]]		[[Category: Bray J]]
	[[Category: Burgess, N]]		[[Category: Burgess N]]
	[[Category: Colebrook, S]]		[[Category: Colebrook S]]
	[[Category: Doyle~~, D A~~]]		[[Category: Doyle DA]]
	[[Category: Edwards, A]]		[[Category: Edwards A]]
	[[Category: Elkins~~, J M~~]]		[[Category: Elkins JM]]
	[[Category: Gileadi, C]]		[[Category: Gileadi C]]
	[[Category: Gorrec, F]]		[[Category: Gorrec F]]
	[[Category: Johansson, C]]		[[Category: Johansson C]]
	[[Category: Papagrigoriou, E]]		[[Category: Papagrigoriou E]]
	[[Category: Phillips, C]]		[[Category: Phillips C]]
	~~[[Category: Structural genomic~~]]		[[Category: Salah E]]
	[[Category: Salah, E]]		[[Category: Savitsky P]]
	[[Category: Savitsky, P]]		[[Category: Schoch G]]
	[[Category: Schoch, G]]		[[Category: Smee C]]
	[[Category: Smee, C]]		[[Category: Soundarajan M]]
	[[Category: Soundarajan, M]]		[[Category: Sundstrom M]]
	[[Category: Sundstrom, M]]		[[Category: Turnbull A]]
	[[Category: Turnbull, A]]		[[Category: Weigelt J]]
	[[Category: Weigelt, J]]		[[Category: Yang X]]
	[[Category: Yang, X]]
	~~[[Category: Adaptor molecule]]~~
	~~[[Category: Protein linker]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Structural protein~~]]

OCA at 07:14, 24 February 2021

2021-02-24T07:14:48Z

← Older revision		Revision as of 07:14, 24 February 2021
Line 1:		Line 1:

	==The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)==		==The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)==
	<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='2fcf' size='340' side='right'caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [~~http~~://pdbe.org/2fcf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fcf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [https://pdbe.org/2fcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [https://www.ebi.ac.uk/pdbsum/2fcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>		[[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Berridge, G]]		[[Category: Berridge, G]]

OCA at 08:59, 14 June 2018

2018-06-14T08:59:14Z

← Older revision		Revision as of 08:59, 14 June 2018
Line 1:		Line 1:

	==The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)==		==The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)==
	<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://pdbe.org/2fcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://pdbe.org/2fcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fcf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fcf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fcf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:22, 11 September 2015

2015-09-11T15:22:25Z

← Older revision		Revision as of 15:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://pdbe.org/2fcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fcf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Berridge, G]]		[[Category: Berridge, G]]

OCA at 18:20, 25 December 2014

2014-12-25T18:20:03Z

← Older revision		Revision as of 18:20, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C]]
	[[Category: Berridge, G.]]		[[Category: Berridge, G]]
	[[Category: Bray, J.]]		[[Category: Bray, J]]
	[[Category: Burgess, N.]]		[[Category: Burgess, N]]
	[[Category: Colebrook, S.]]		[[Category: Colebrook, S]]
	[[Category: Doyle, D A.]]		[[Category: Doyle, D A]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A]]
	[[Category: Elkins, J M.]]		[[Category: Elkins, J M]]
	[[Category: Gileadi, C.]]		[[Category: Gileadi, C]]
	[[Category: Gorrec, F.]]		[[Category: Gorrec, F]]
	[[Category: Johansson, C.]]		[[Category: Johansson, C]]
	[[Category: Papagrigoriou, E.]]		[[Category: Papagrigoriou, E]]
	[[Category: Phillips, C.]]		[[Category: Phillips, C]]
	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Salah, E.]]		[[Category: Salah, E]]
	[[Category: Savitsky, P.]]		[[Category: Savitsky, P]]
	[[Category: Schoch, G.]]		[[Category: Schoch, G]]
	[[Category: Smee, C.]]		[[Category: Smee, C]]
	[[Category: Soundarajan, M.]]		[[Category: Soundarajan, M]]
	[[Category: Sundstrom, M.]]		[[Category: Sundstrom, M]]
	[[Category: Turnbull, A.]]		[[Category: Turnbull, A]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Yang, X.]]		[[Category: Yang, X]]
	[[Category: Adaptor molecule]]		[[Category: Adaptor molecule]]
	[[Category: Protein linker]]		[[Category: Protein linker]]
	[[Category: Sgc]]		[[Category: Sgc]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 01:56, 30 September 2014

2014-09-30T01:56:29Z

← Older revision		Revision as of 01:56, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fcf~~.~~png~~\|~~left~~\|~~200px~~]]		==The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)==
			<StructureSection load='2fcf' size='340' side='right' caption='[[2fcf]], [[Resolution\|resolution]] 1.76Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FCF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fcf RCSB], [http://www.ebi.ac.uk/pdbsum/2fcf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fcf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			PDZ domains are protein-protein interaction modules that generally bind to the C termini of their target proteins. The C-terminal four amino acids of a prospective binding partner of a PDZ domain are typically the determinants of binding specificity. In an effort to determine the structures of a number of PDZ domains we have included appropriate four residue extensions on the C termini of PDZ domain truncation mutants, designed for self-binding. Multiple truncations of each PDZ domain were generated. The four residue extensions, which represent known specificity sequences of the target PDZ domains and cover both class I and II motifs, form intermolecular contacts in the expected manner for the interactions of PDZ domains with protein C termini for both classes. We present the structures of eight unique PDZ domains crystallized using this approach and focus on four which provide information on selectivity (PICK1 and the third PDZ domain of DLG2), binding site flexibility (the third PDZ domain of MPDZ), and peptide-domain interactions (MPDZ 12th PDZ domain). Analysis of our results shows a clear improvement in the chances of obtaining PDZ domain crystals by using this approach compared to similar truncations of the PDZ domains without the C-terminal four residue extensions.

	~~{{STRUCTURE_2fcf\| PDB=2fcf \| SCENE= }}~~		Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.,Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA Protein Sci. 2007 Apr;16(4):683-94. PMID:17384233<ref>PMID:17384233</ref>

	~~===The crystal structure~~ of the ~~7th PDZ domain of MPDZ (MUPP-1)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17384233}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fcf]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017384233<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]

OCA: Protected "2fcf" [edit=sysop:move=sysop]

2013-01-07T14:28:43Z

Protected "2fcf" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:28, 7 January 2013
(No difference)

OCA at 14:28, 7 January 2013

2013-01-07T14:28:39Z

← Older revision		Revision as of 14:28, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fcf.png\|left\|200px]]		[[Image:2fcf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fcf", creates the "Structure Box" on the page.~~
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	{{STRUCTURE_2fcf\| PDB=2fcf \| SCENE= }}		{{STRUCTURE_2fcf\| PDB=2fcf \| SCENE= }}

	===The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)===		===The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17384233}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17384233 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17384233}}		{{ABSTRACT_PUBMED_17384233}}

	==About this Structure==		==About this Structure==
	~~2FCF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].		[[2fcf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17384233~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017384233</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
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	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:59:22 2009''~~

OCA at 23:59, 17 February 2009

2009-02-17T23:59:23Z

← Older revision		Revision as of 23:59, 17 February 2009
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	==About this Structure==		==About this Structure==
	2FCF is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].		2FCF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].

	==Reference==		==Reference==
	Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions., Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA, Protein Sci. 2007 Apr;16(4):683-94. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17384233 17384233]~~		<ref group="xtra">PMID:17384233</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
	[[Category: Berridge, G.]]		[[Category: Berridge, G.]]
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	[[Category: Structural protein]]		[[Category: Structural protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 1 21~~:01:~~36 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:59:22 2009''

OCA at 18:01, 1 October 2008

2008-10-01T18:01:37Z

← Older revision		Revision as of 18:01, 1 October 2008
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	[[Image:2fcf.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2fcf.png\|left\|200px]]

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	{{STRUCTURE_2fcf\| PDB=2fcf \| SCENE= }}		{{STRUCTURE_2fcf\| PDB=2fcf \| SCENE= }}

	~~'''~~The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)~~'''~~		===The crystal structure of the 7th PDZ domain of MPDZ (MUPP-1)===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_17384233}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 17384233 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_17384233}}

	==About this Structure==		==About this Structure==
	2FCF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].		2FCF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCF OCA].

			==Reference==
			Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions., Elkins JM, Papagrigoriou E, Berridge G, Yang X, Phillips C, Gileadi C, Savitsky P, Doyle DA, Protein Sci. 2007 Apr;16(4):683-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17384233 17384233]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Single protein]]		[[Category: Single protein]]
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	[[Category: Burgess, N.]]		[[Category: Burgess, N.]]
	[[Category: Colebrook, S.]]		[[Category: Colebrook, S.]]
	[[Category: Doyle, D.]]		[[Category: Doyle, D A.]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A.]]
	[[Category: Elkins, J.]]		[[Category: Elkins, J M.]]
	[[Category: Gileadi, C.]]		[[Category: Gileadi, C.]]
	[[Category: Gorrec, F.]]		[[Category: Gorrec, F.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 03~~:43:40 2008''		[[Category: Structural protein]]

			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 1 21:01:36 2008''