2fd4 - Revision history

OCA at 09:22, 14 February 2024

2024-02-14T09:22:51Z

← Older revision		Revision as of 09:22, 14 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [https://pdbe.org/2fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [https://pdbe.org/2fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>		[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses.

	A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.,Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:16373536<ref>PMID:16373536</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2fd4" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 07:13, 8 February 2023

2023-02-08T07:13:08Z

← Older revision		Revision as of 07:13, 8 February 2023
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	<StructureSection load='2fd4' size='340' side='right'caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2fd4' size='340' side='right'caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_19310 Atcc 19310~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [https://pdbe.org/2fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [https://pdbe.org/2fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>		[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 19310]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Janjusevic, R~~]]		[[Category: Pseudomonas syringae]]
	[[Category: ~~Stebbins, C E~~]]		[[Category: Janjusevic R]]
	[[Category: ~~Avrptob]]~~		[[Category: Stebbins CE]]
	~~[[Category: Ligase]]~~
	~~[[Category: Pseudomona]]~~
	~~[[Category: Ring finger]]~~
	~~[[Category: U-box]]~~
	~~[[Category: Ubiquitin ligase~~]]

OCA at 09:54, 5 May 2021

2021-05-05T09:54:08Z

← Older revision		Revision as of 09:54, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2fd4' size='340' side='right'caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2fd4' size='340' side='right'caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [~~http~~://pdbe.org/2fd4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [https://pdbe.org/2fd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>		[[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:20, 24 July 2019

2019-07-24T09:20:22Z

← Older revision		Revision as of 09:20, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of AvrPtoB (436-553)==		==Crystal Structure of AvrPtoB (436-553)==
	<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2fd4' size='340' side='right'caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
	*[[Avirulence protein\|Avirulence protein]]		*[[Avirulence protein 3D structures\|Avirulence protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 19310]]		[[Category: Atcc 19310]]
			[[Category: Large Structures]]
	[[Category: Janjusevic, R]]		[[Category: Janjusevic, R]]
	[[Category: Stebbins, C E]]		[[Category: Stebbins, C E]]

OCA at 07:36, 18 October 2017

2017-10-18T07:36:49Z

← Older revision		Revision as of 07:36, 18 October 2017
Line 1:		Line 1:

	==Crystal Structure of AvrPtoB (436-553)==		==Crystal Structure of AvrPtoB (436-553)==
	<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://pdbe.org/2fd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://pdbe.org/2fd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fd4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:21, 11 September 2015

2015-09-11T03:21:00Z

← Older revision		Revision as of 03:21, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_syringae Pseudomonas syringae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://pdbe.org/2fd4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fd4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Pseudomonas syringae~~]]		[[Category: Atcc 19310]]
	[[Category: Janjusevic, R]]		[[Category: Janjusevic, R]]
	[[Category: Stebbins, C E]]		[[Category: Stebbins, C E]]

OCA at 13:47, 17 December 2014

2014-12-17T13:47:22Z

← Older revision		Revision as of 13:47, 17 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2fd4\| PDB=2fd4 \| SCENE= }}~~		==Crystal Structure of AvrPtoB (436-553)==
	===Crystal Structure of AvrPtoB (436-553)===		<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~{{ABSTRACT_PUBMED_16373536}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br>
			</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses.

	~~==About this Structure==~~		A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.,Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:16373536<ref>PMID:16373536</ref>
	~~[[2fd4]]~~ is ~~a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2FD4 OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Avirulence protein\|Avirulence protein]]		*[[Avirulence protein\|Avirulence protein]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Pseudomonas syringae]]		[[Category: Pseudomonas syringae]]
	[[Category: Janjusevic, R.]]		[[Category: Janjusevic, R]]
	[[Category: Stebbins, C E.]]		[[Category: Stebbins, C E]]
	[[Category: Avrptob]]		[[Category: Avrptob]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 10:29, 11 March 2013

2013-03-11T10:29:12Z

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	~~[[Image:2fd4.png\|left\|200px]]~~

	{{STRUCTURE_2fd4\| PDB=2fd4 \| SCENE= }}		{{STRUCTURE_2fd4\| PDB=2fd4 \| SCENE= }}

	===Crystal Structure of AvrPtoB (436-553)===		===Crystal Structure of AvrPtoB (436-553)===

	{{ABSTRACT_PUBMED_16373536}}		{{ABSTRACT_PUBMED_16373536}}

OCA: Protected "2fd4" [edit=sysop:move=sysop]

2013-01-07T14:29:19Z

Protected "2fd4" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:29, 7 January 2013
(No difference)

OCA at 14:29, 7 January 2013

2013-01-07T14:29:16Z

← Older revision		Revision as of 14:29, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fd4.png\|left\|200px]]		[[Image:2fd4.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fd4", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fd4\| PDB=2fd4 \| SCENE= }}		{{STRUCTURE_2fd4\| PDB=2fd4 \| SCENE= }}

	===Crystal Structure of AvrPtoB (436-553)===		===Crystal Structure of AvrPtoB (436-553)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16373536}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16373536 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_16373536}}		{{ABSTRACT_PUBMED_16373536}}

	==About this Structure==		==About this Structure==
	~~2FD4 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA].		[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA].

	==~~Reference~~==		==See Also==
	A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase., Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE, Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:[~~http://www.ncbi.nlm.nih.gov/pubmed/16373536 16373536~~]		*[[Avirulence protein\|Avirulence protein]]
	[[Category: Pseudomonas syringae]]		[[Category: Pseudomonas syringae]]
	~~[[Category: Single protein]]~~
	[[Category: Janjusevic, R.]]		[[Category: Janjusevic, R.]]
	[[Category: Stebbins, C E.]]		[[Category: Stebbins, C E.]]
	[[Category: Avrptob]]		[[Category: Avrptob]]
			[[Category: Ligase]]
	[[Category: Pseudomona]]		[[Category: Pseudomona]]
	[[Category: Ring finger]]		[[Category: Ring finger]]
	[[Category: U-box]]		[[Category: U-box]]
	[[Category: Ubiquitin ligase]]		[[Category: Ubiquitin ligase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:02:56 2008''~~