2ffb - Revision history

OCA at 09:26, 30 August 2023

2023-08-30T09:26:10Z

← Older revision		Revision as of 09:26, 30 August 2023
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	<StructureSection load='2ffb' size='340' side='right'caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ffb' size='340' side='right'caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]~~</~~div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat"~~>~~hlyB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [https://pdbe.org/2ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [https://www.ebi.ac.uk/pdbsum/2ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [https://pdbe.org/2ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [https://www.ebi.ac.uk/pdbsum/2ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HLYBP_ECOLX HLYBP_ECOLX]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.		[https://www.uniprot.org/uniprot/HLYBP_ECOLX HLYBP_ECOLX] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Holland~~, I B~~]]		[[Category: Holland IB]]
	[[Category: Jenewein, S]]		[[Category: Jenewein S]]
	[[Category: Jumpertz, T]]		[[Category: Jumpertz T]]
	[[Category: Oswald, C]]		[[Category: Oswald C]]
	[[Category: Schmitt, L]]		[[Category: Schmitt L]]
	[[Category: Zaitseva, J]]		[[Category: Zaitseva J]]
	~~[[Category: Abc-transporter]]~~
	~~[[Category: Atpase]]~~
	~~[[Category: Transport protein~~]]

OCA at 07:16, 24 February 2021

2021-02-24T07:16:24Z

← Older revision		Revision as of 07:16, 24 February 2021
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	==The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP==		==The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP==
	<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ffb' size='340' side='right'caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [~~http~~://pdbe.org/2ffb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ffb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [https://pdbe.org/2ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [https://www.ebi.ac.uk/pdbsum/2ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HLYBP_ECOLX HLYBP_ECOLX]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.		[[https://www.uniprot.org/uniprot/HLYBP_ECOLX HLYBP_ECOLX]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[ABC transporter\|ABC transporter]]		*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Holland, I B]]		[[Category: Holland, I B]]
	[[Category: Jenewein, S]]		[[Category: Jenewein, S]]

OCA at 09:23, 14 June 2018

2018-06-14T09:23:36Z

← Older revision		Revision as of 09:23, 14 June 2018
Line 1:		Line 1:

	==The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP==		==The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP==
	<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://pdbe.org/2ffb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://pdbe.org/2ffb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:17, 8 February 2016

2016-02-08T12:17:32Z

← Older revision		Revision as of 12:17, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ffb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:29, 10 September 2015

2015-09-10T11:29:35Z

← Older revision		Revision as of 11:29, 10 September 2015
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	<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://pdbe.org/2ffb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~HLYBP_ECOLI HLYBP_ECOLI~~]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.		[[http://www.uniprot.org/uniprot/HLYBP_ECOLX HLYBP_ECOLX]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ffb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Holland, I B]]		[[Category: Holland, I B]]
	[[Category: Jenewein, S]]		[[Category: Jenewein, S]]

OCA at 23:15, 24 December 2014

2014-12-24T23:15:29Z

← Older revision		Revision as of 23:15, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HLYBP_ECOLI HLYBP_ECOLI]] Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Holland, I B.]]		[[Category: Holland, I B]]
	[[Category: Jenewein, S.]]		[[Category: Jenewein, S]]
	[[Category: Jumpertz, T.]]		[[Category: Jumpertz, T]]
	[[Category: Oswald, C.]]		[[Category: Oswald, C]]
	[[Category: Schmitt, L.]]		[[Category: Schmitt, L]]
	[[Category: Zaitseva, J.]]		[[Category: Zaitseva, J]]
	[[Category: Abc-transporter]]		[[Category: Abc-transporter]]
	[[Category: Atpase]]		[[Category: Atpase]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 03:15, 29 September 2014

2014-09-29T03:15:50Z

← Older revision		Revision as of 03:15, 29 September 2014
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	[[Image:~~2ffb~~.~~png~~\|~~left~~\|~~200px~~]]		==The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP==
			<StructureSection load='2ffb' size='340' side='right' caption='[[2ffb]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt0\|1mt0]], [[1xef\|1xef]], [[2ff7\|2ff7]], [[2ffa\|2ffa]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hlyB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffb RCSB], [http://www.ebi.ac.uk/pdbsum/2ffb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The ATP-binding cassette (ABC)-transporter haemolysin (Hly)B, a central element of a Type I secretion machinery, acts in concert with two additional proteins in Escherichia coli to translocate the toxin HlyA directly from the cytoplasm to the exterior. The basic set of crystal structures necessary to describe the catalytic cycle of the isolated HlyB-NBD (nucleotide-binding domain) has now been completed. This allowed a detailed analysis with respect to hinge regions, functionally important key residues and potential energy storage devices that revealed many novel features. These include a structural asymmetry within the ATP dimer that was significantly enhanced in the presence of Mg2+, indicating a possible functional asymmetry in the form of one open and one closed phosphate exit tunnel. Guided by the structural analysis, we identified two amino acids, closing one tunnel by an apparent salt bridge. Mutation of these residues abolished ATP-dependent cooperativity of the NBDs. The implications of these new findings for the coupling of ATP binding and hydrolysis to functional activity are discussed.

	~~{{STRUCTURE_2ffb\| PDB=2ffb \| SCENE= }}~~		A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer.,Zaitseva J, Oswald C, Jumpertz T, Jenewein S, Wiedenmann A, Holland IB, Schmitt L EMBO J. 2006 Jul 26;25(14):3432-43. Epub 2006 Jul 6. PMID:16858415<ref>PMID:16858415</ref>

	~~===The crystal structure~~ of the ~~HlyB-NBD E631Q mutant in complex with ADP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16858415}}~~

	~~==About this Structure==~~
	~~[[2ffb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2FFB OCA].~~

	==See Also==		==See Also==
	*[[ABC transporter\|ABC transporter]]		*[[ABC transporter\|ABC transporter]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016858415<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Holland, I B.]]		[[Category: Holland, I B.]]

OCA at 10:06, 20 October 2012

2012-10-20T10:06:32Z

← Older revision		Revision as of 10:06, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2ffb]] is a 1 chain structure ~~of [[ABC transporter]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA].		[[2ffb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFB OCA].

	==See Also==		==See Also==

OCA at 01:00, 26 July 2012

2012-07-26T01:00:21Z

← Older revision		Revision as of 01:00, 26 July 2012
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	[[Image:2ffb.png\|left\|200px]]		[[Image:2ffb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ffb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ffb\| PDB=2ffb \| SCENE= }}		{{STRUCTURE_2ffb\| PDB=2ffb \| SCENE= }}

	===The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP===		===The crystal structure of the HlyB-NBD E631Q mutant in complex with ADP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16858415}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16858415 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16858415}}		{{ABSTRACT_PUBMED_16858415}}

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	==See Also==		==See Also==
	*[[ABC transporter]]		*[[ABC transporter\|ABC transporter]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16858415~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016858415</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Holland, I B.]]		[[Category: Holland, I B.]]

OCA: Protected "2ffb" [edit=sysop:move=sysop]

2010-12-26T20:44:58Z

Protected "2ffb" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:44, 26 December 2010
(No difference)