2ffk - Revision history

OCA at 09:06, 6 November 2024

2024-11-06T09:06:46Z

← Older revision		Revision as of 09:06, 6 November 2024
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	==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==		==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==
	<StructureSection load='2ffk' size='340' side='right'caption='[[2ffk~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>		<StructureSection load='2ffk' size='340' side='right'caption='[[2ffk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2fin\|2fin]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
	~~<tr~~ id~~='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class~~="~~sblockDat~~">~~CCL4~~, ~~LAG1, MIP1B, SCYA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [https://pdbe.org/2ffk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [https://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [https://pdbe.org/2ffk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [https://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~CCL4_HUMAN CCL4_HUMAN~~]] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>		[https://www.uniprot.org/uniprot/O10647_9POXV O10647_9POXV]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
	[[Category: Zhang, L]]		[[Category: Zhang L]]
	~~[[Category: Chemokine]]~~
	~~[[Category: Pox virus]]~~
	~~[[Category: Protein-protein complex]]~~
	~~[[Category: Viral cc chemokine inhibitor]]~~
	~~[[Category: Virus-viral protein-cytokine complex~~]]

OCA at 07:16, 24 February 2021

2021-02-24T07:16:30Z

← Older revision		Revision as of 07:16, 24 February 2021
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	==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==		==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==
	<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2ffk' size='340' side='right'caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FFK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fin\|2fin]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [~~http~~://pdbe.org/2ffk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [https://pdbe.org/2ffk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [https://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>		[[https://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
	[[Category: Zhang, L]]		[[Category: Zhang, L]]

OCA at 09:13, 14 June 2018

2018-06-14T09:13:57Z

← Older revision		Revision as of 09:13, 14 June 2018
Line 1:		Line 1:

	==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==		==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==
	<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://pdbe.org/2ffk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://pdbe.org/2ffk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ffk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:13, 11 September 2015

2015-09-11T10:13:13Z

← Older revision		Revision as of 10:13, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://pdbe.org/2ffk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ffk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
	[[Category: Zhang, L]]		[[Category: Zhang, L]]

OCA at 14:59, 25 December 2014

2014-12-25T14:59:25Z

← Older revision		Revision as of 14:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
	[[Category: Zhang, L.]]		[[Category: Zhang, L]]
	[[Category: Chemokine]]		[[Category: Chemokine]]
	[[Category: Pox virus]]		[[Category: Pox virus]]

OCA at 02:58, 30 September 2014

2014-09-30T02:58:00Z

← Older revision		Revision as of 02:58, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ffk~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==
			<StructureSection load='2ffk' size='340' side='right' caption='[[2ffk]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fin\|2fin]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL4, LAG1, MIP1B, SCYA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [http://www.ebi.ac.uk/pdbsum/2ffk PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses residues from its beta-sheet II to interact with a surface of MIP-1beta that includes residues adjacent to its N terminus, as well as residues in the 20's region and the 40's loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.

	~~{{STRUCTURE_2ffk\| PDB=2ffk \| SCENE= }}~~		Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta.,Zhang L, Derider M, McCornack MA, Jao SC, Isern N, Ness T, Moyer R, LiWang PJ Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13985-90. Epub 2006 Sep 8. PMID:16963564<ref>PMID:16963564</ref>

	~~===Solution structure~~ of the ~~complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16963564}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ffk]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016963564<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]

OCA: Protected "2ffk" [edit=sysop:move=sysop]

2013-01-07T15:18:53Z

Protected "2ffk" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:18, 7 January 2013
(No difference)

OCA at 15:18, 7 January 2013

2013-01-07T15:18:49Z

← Older revision		Revision as of 15:18, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2ffk.png\|left\|200px]]		[[Image:2ffk.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ffk", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ffk\| PDB=2ffk \| SCENE= }}		{{STRUCTURE_2ffk\| PDB=2ffk \| SCENE= }}

	===Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure===		===Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16963564}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16963564 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16963564}}		{{ABSTRACT_PUBMED_16963564}}

	==About this Structure==		==About this Structure==
	~~2FFK~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].		[[2ffk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16963564~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016963564</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
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	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]
	[[Category: Viral cc chemokine inhibitor]]		[[Category: Viral cc chemokine inhibitor]]
			[[Category: Virus-viral protein-cytokine complex]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 19:39:45 2009''~~

OCA at 17:39, 17 February 2009

2009-02-17T17:39:46Z

← Older revision		Revision as of 17:39, 17 February 2009
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	==About this Structure==		==About this Structure==
	2FFK is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].		2FFK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].

	==Reference==		==Reference==
	Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta., Zhang L, Derider M, McCornack MA, Jao SC, Isern N, Ness T, Moyer R, LiWang PJ, Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13985-90. Epub 2006 Sep 8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16963564 16963564]~~		<ref group="xtra">PMID:16963564</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Protein complex]]~~
	[[Category: Rabbitpox virus]]		[[Category: Rabbitpox virus]]
	[[Category: Zhang, L.]]		[[Category: Zhang, L.]]
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	[[Category: Viral cc chemokine inhibitor]]		[[Category: Viral cc chemokine inhibitor]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03~~:32:~~13 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:39:45 2009''

OCA at 00:32, 29 July 2008

2008-07-29T00:32:17Z

← Older revision		Revision as of 00:32, 29 July 2008
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	[[Image:2ffk.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2ffk.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2ffk\| PDB=2ffk \| SCENE= }}		{{STRUCTURE_2ffk\| PDB=2ffk \| SCENE= }}

	~~'''~~Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure~~'''~~		===Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure===


	~~==Overview==~~		<!--
	~~Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes~~, ~~giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity~~, ~~acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR~~ to ~~determine~~ the ~~structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta~~ (~~macrophage inflammatory protein 1beta~~)~~. vCCI binds to~~ the ~~chemokine with 1:1 stoichiometry, forming a complex of 311 aa~~. ~~vCCI uses residues from its beta~~-~~sheet II to interact with a surface of MIP~~-1beta that includes residues adjacent to its N terminus, as well as residues in the 20's region and the 40's loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.		The line below this paragraph, {{ABSTRACT_PUBMED_16963564}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16963564 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16963564}}

	==About this Structure==		==About this Structure==
	2FFK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].		2FFK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].

	==Reference==		==Reference==
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	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]
	[[Category: Viral cc chemokine inhibitor]]		[[Category: Viral cc chemokine inhibitor]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 03:50:13 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:32:13 2008''