2fgp - Revision history

OCA at 13:05, 26 July 2023

2023-07-26T13:05:42Z

← Older revision		Revision as of 13:05, 26 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FGP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FGP FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]~~</~~div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [https://pdbe.org/2fgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [https://www.ebi.ac.uk/pdbsum/2fgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [https://pdbe.org/2fgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [https://www.ebi.ac.uk/pdbsum/2fgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgp ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
	*[[Ribozyme\|Ribozyme]]		*[[Ribozyme 3D structures\|Ribozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Salter~~, J D~~]]		[[Category: Salter JD]]
	[[Category: Wedekind~~, J E]]~~		[[Category: Wedekind JE]]
	~~[[Category: Diaminopurine]]~~
	~~[[Category: G8]]~~
	~~[[Category: In-line geometry]]~~
	~~[[Category: Mutant]]~~
	~~[[Category: Ribozyme]]~~
	~~[[Category: Rna~~]]

OCA at 20:39, 20 October 2021

2021-10-20T20:39:37Z

← Older revision		Revision as of 20:39, 20 October 2021
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	<StructureSection load='2fgp' size='340' side='right'caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2fgp' size='340' side='right'caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FGP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FGP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [~~http~~://pdbe.org/2fgp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fgp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [https://pdbe.org/2fgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [https://www.ebi.ac.uk/pdbsum/2fgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:27, 11 December 2019

2019-12-11T19:27:57Z

← Older revision		Revision as of 19:27, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6==		==Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6==
	<StructureSection load='2fgp' size='340' side='right' caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2fgp' size='340' side='right'caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FGP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FGP FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Salter, J D]]		[[Category: Salter, J D]]
	[[Category: Wedekind, J E]]		[[Category: Wedekind, J E]]

OCA at 18:48, 24 January 2018

2018-01-24T18:48:53Z

← Older revision		Revision as of 18:48, 24 January 2018
Line 1:		Line 1:

	==Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6==		==Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6==
	<StructureSection load='2fgp' size='340' side='right' caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2fgp' size='340' side='right' caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://pdbe.org/2fgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://pdbe.org/2fgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fgp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:10, 11 September 2015

2015-09-11T23:10:54Z

← Older revision		Revision as of 23:10, 11 September 2015
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://pdbe.org/2fgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fgp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:12, 16 January 2015

2015-01-16T09:12:48Z

← Older revision		Revision as of 09:12, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FGP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FGP FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Salter, J D.]]		[[Category: Salter, J D]]
	[[Category: Wedekind, J E.]]		[[Category: Wedekind, J E]]
	[[Category: Diaminopurine]]		[[Category: Diaminopurine]]
	[[Category: G8]]		[[Category: G8]]

OCA at 04:06, 29 September 2014

2014-09-29T04:06:18Z

← Older revision		Revision as of 04:06, 29 September 2014
Line 1:		Line 1:
	[[~~Image~~:~~2fgp~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6==
			<StructureSection load='2fgp' size='340' side='right' caption='[[2fgp]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FGP FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N6G:((2R,3S,4R,5S)-5-(2,6-DIAMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>N6G</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zfr\|1zfr]], [[1zft\|1zft]], [[2bcz\|2bcz]], [[1zfv\|1zfv]], [[1zfx\|1zfx]], [[2bcy\|2bcy]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fgp RCSB], [http://www.ebi.ac.uk/pdbsum/2fgp PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The hairpin ribozyme requires functional group contributions from G8 to assist in phosphodiester bond cleavage. Previously, replacement of G8 by a series of nucleobase variants showed little effect on interdomain docking, but a 3-250-fold effect on catalysis. To identify G8 features that contribute to catalysis within the hairpin ribozyme active site, structures for five base variants were determined by X-ray crystallography in a resolution range between 2.3 and 2.7 A. For comparison, a native all-RNA "G8" hairpin ribozyme structure was refined to 2.05 A resolution. The native structure revealed a scissile bond angle (tau) of 158 degrees, which is close to the requisite 180 degrees "in-line" geometry. Mutations G8(inosine), G8(diaminopurine), G8(aminopurine), G8(adenosine), and G8(uridine) folded properly, but exhibited nonideal scissile bond geometries (tau ranging from 118 degrees to 93 degrees) that paralleled their diminished solution activities. A superposition ensemble of all structures, including a previously described hairpin ribozyme-vanadate complex, indicated the scissile bond can adopt a variety of conformations resulting from perturbation of the chemical environment and provided a rationale for how the exocyclic amine of nucleobase 8 promotes productive, in-line geometry. Changes at position 8 also caused variations in the A-1 sugar pucker. In this regard, variants A8 and U8 appeared to represent nonproductive ground states in which their 2'-OH groups mimicked the pro-R, nonbridging oxygen of the vanadate transition-state complex. Finally, the results indicated that ordered water molecules bind near the 2'-hydroxyl of A-1, lending support to the hypothesis that solvent may play an important role in the reaction.

	~~{{STRUCTURE_2fgp\| PDB=2fgp \| SCENE= }}~~		Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer.,Salter J, Krucinska J, Alam S, Grum-Tokars V, Wedekind JE Biochemistry. 2006 Jan 24;45(3):686-700. PMID:16411744<ref>PMID:16411744</ref>

	~~===Crystal structure of a minimal~~, ~~all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16411744}}~~

	~~==About this Structure==~~
	~~[[2fgp]] is~~ a ~~4 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2FGP OCA].~~

	==See Also==		==See Also==
	*[[Ribozyme\|Ribozyme]]		*[[Ribozyme\|Ribozyme]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016411744<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Salter, J D.]]		[[Category: Salter, J D.]]
	[[Category: Wedekind, J E.]]		[[Category: Wedekind, J E.]]

OCA at 21:22, 20 October 2012

2012-10-20T21:22:23Z

← Older revision		Revision as of 21:22, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2fgp]] is a 4 chain structure ~~of [[Ribozyme]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA].		[[2fgp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA].

	==See Also==		==See Also==

OCA: Protected "2fgp" [edit=sysop:move=sysop]

2012-07-27T13:03:05Z

Protected "2fgp" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:03, 27 July 2012
(No difference)

OCA at 13:03, 27 July 2012

2012-07-27T13:03:04Z

← Older revision		Revision as of 13:03, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2fgp.png\|left\|200px]]		[[Image:2fgp.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fgp", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fgp\| PDB=2fgp \| SCENE= }}		{{STRUCTURE_2fgp\| PDB=2fgp \| SCENE= }}

	===Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6===		===Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16411744}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16411744 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16411744}}		{{ABSTRACT_PUBMED_16411744}}

	==About this Structure==		==About this Structure==
	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA].		[[2fgp]] is a 4 chain structure of [[Ribozyme]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGP OCA].

			==See Also==
			*[[Ribozyme\|Ribozyme]]

	==Reference==		==Reference==
	Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer., Salter J, Krucinska J, Alam S, Grum-Tokars V, Wedekind JE, Biochemistry. 2006 Jan 24;45(3):686-700. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16411744 16411744]~~		<ref group="xtra">PMID:016411744</ref><references group="xtra"/>
	[[Category: Salter, J D.]]		[[Category: Salter, J D.]]
	[[Category: Wedekind, J E.]]		[[Category: Wedekind, J E.]]
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	[[Category: Mutant]]		[[Category: Mutant]]
	[[Category: Ribozyme]]		[[Category: Ribozyme]]
			[[Category: Rna]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 13:18:12 2008''~~