2flu - Revision history

OCA at 07:59, 30 October 2024

2024-10-30T07:59:50Z

← Older revision		Revision as of 07:59, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2flu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2flu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:28, 30 August 2023

2023-08-30T09:28:52Z

← Older revision		Revision as of 09:28, 30 August 2023
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	<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1u6d\|1u6d]]~~, [[~~1zgk~~\|~~1zgk~~]]~~</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [https://pdbe.org/2flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [https://www.ebi.ac.uk/pdbsum/2flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [https://pdbe.org/2flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [https://www.ebi.ac.uk/pdbsum/2flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~NF2L2_HUMAN NF2L2_HUMAN~~]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>		[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Beamer, L]]		[[Category: Beamer L]]
	[[Category: Hannink, M]]		[[Category: Hannink M]]
	[[Category: Li, X]]		[[Category: Li X]]
	[[Category: Lo, J]]		[[Category: Lo J]]
	~~[[Category: Beta-propeller]]~~
	~~[[Category: Kelch domain]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Protein-peptide complex~~]]

OCA at 16:06, 22 December 2021

2021-12-22T16:06:22Z

← Older revision		Revision as of 16:06, 22 December 2021
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	<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u6d\|1u6d]], [[1zgk\|1zgk]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [~~http~~://pdbe.org/2flu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2flu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [https://pdbe.org/2flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [https://www.ebi.ac.uk/pdbsum/2flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>		[[https://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:51, 18 March 2020

2020-03-18T10:51:47Z

← Older revision		Revision as of 10:51, 18 March 2020
Line 1:		Line 1:

	==Crystal Structure of the Kelch-Neh2 Complex==		==Crystal Structure of the Kelch-Neh2 Complex==
	<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2flu' size='340' side='right'caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
	*[[Kelch-like protein\|Kelch-like protein]]		*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Beamer, L]]		[[Category: Beamer, L]]
	[[Category: Hannink, M]]		[[Category: Hannink, M]]

OCA at 09:11, 14 June 2018

2018-06-14T09:11:29Z

← Older revision		Revision as of 09:11, 14 June 2018
Line 1:		Line 1:

	==Crystal Structure of the Kelch-Neh2 Complex==		==Crystal Structure of the Kelch-Neh2 Complex==
	<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://pdbe.org/2flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://pdbe.org/2flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2flu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2flu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2flu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:55, 8 February 2016

2016-02-08T23:55:48Z

← Older revision		Revision as of 23:55, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://pdbe.org/2flu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2flu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2flu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Kelch-like ~~ECH-associated~~ protein 1\|Kelch-like ~~ECH-associated~~ protein 1]]		*[[Kelch-like protein\|Kelch-like protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Beamer, L]]		[[Category: Beamer, L]]
	[[Category: Hannink, M]]		[[Category: Hannink, M]]

OCA at 03:02, 25 December 2014

2014-12-25T03:02:05Z

← Older revision		Revision as of 03:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Beamer, L.]]		[[Category: Beamer, L]]
	[[Category: Hannink, M.]]		[[Category: Hannink, M]]
	[[Category: Li, X.]]		[[Category: Li, X]]
	[[Category: Lo, J.]]		[[Category: Lo, J]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Kelch domain]]		[[Category: Kelch domain]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]

OCA at 08:11, 30 September 2014

2014-09-30T08:11:46Z

← Older revision		Revision as of 08:11, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2flu~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of the Kelch-Neh2 Complex==
			<StructureSection load='2flu' size='340' side='right' caption='[[2flu]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLU FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u6d\|1u6d]], [[1zgk\|1zgk]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2flu RCSB], [http://www.ebi.ac.uk/pdbsum/2flu PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2flu_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif. The Nrf2 peptide contains two short antiparallel beta-strands connected by two overlapping type I beta-turns stabilized by the aspartate and threonine residues. The beta-turn region fits into a binding pocket on the top face of the Kelch domain and the glutamate residues form multiple hydrogen bonds with highly conserved residues in Keap1. Mutagenesis experiments confirmed the role of individual amino acids for binding of Nrf2 to Keap1 and for Keap1-mediated repression of Nrf2-dependent gene expression. Our results provide a detailed picture of how a BTB-Kelch substrate adaptor protein binds to its cognate substrate and will enable the rational design of novel chemopreventive agents.

	~~{{STRUCTURE_2flu\| PDB=2flu \| SCENE= }}~~		Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.,Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M EMBO J. 2006 Aug 9;25(15):3605-17. Epub 2006 Aug 3. PMID:16888629<ref>PMID:16888629</ref>

	~~===Crystal Structure~~ of the ~~Kelch-Neh2 Complex===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_16888629}}~~		==See Also==
			*[[Kelch-like ECH-associated protein 1\|Kelch-like ECH-associated protein 1]]
	==~~About this Structure~~==		== References ==
	[[~~2flu~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:016888629<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Beamer, L.]]		[[Category: Beamer, L.]]

OCA: Protected "2flu" [edit=sysop:move=sysop]

2013-01-07T10:38:34Z

Protected "2flu" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:38, 7 January 2013
(No difference)

OCA at 10:38, 7 January 2013

2013-01-07T10:38:29Z

← Older revision		Revision as of 10:38, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2flu.png\|left\|200px]]		[[Image:2flu.png\|left\|200px]]

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	{{STRUCTURE_2flu\| PDB=2flu \| SCENE= }}		{{STRUCTURE_2flu\| PDB=2flu \| SCENE= }}

	===Crystal Structure of the Kelch-Neh2 Complex===		===Crystal Structure of the Kelch-Neh2 Complex===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16888629}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_16888629}}		{{ABSTRACT_PUBMED_16888629}}

	==About this Structure==		==About this Structure==
	~~2FLU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA].		[[2flu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLU OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16888629~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016888629</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Beamer, L.]]		[[Category: Beamer, L.]]
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	[[Category: Lo, J.]]		[[Category: Lo, J.]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Kelch domain~~,protein-peptide complex~~]]		[[Category: Kelch domain]]
			[[Category: Ligase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 04:40:17 2009''~~		[[Category: Protein-peptide complex]]