2fly - Revision history

OCA at 07:59, 30 October 2024

2024-10-30T07:59:51Z

← Older revision		Revision as of 07:59, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [https://pdbe.org/2fly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [https://www.ebi.ac.uk/pdbsum/2fly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [https://pdbe.org/2fly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [https://www.ebi.ac.uk/pdbsum/2fly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>

OCA at 16:36, 13 December 2023

2023-12-13T16:36:12Z

← Older revision		Revision as of 16:36, 13 December 2023
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	==Proadrenomedullin N-Terminal 20 Peptide==		==Proadrenomedullin N-Terminal 20 Peptide==
	<StructureSection load='2fly' size='340' side='right'caption='[[2fly~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2fly' size='340' side='right'caption='[[2fly]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [https://pdbe.org/2fly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [https://www.ebi.ac.uk/pdbsum/2fly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [https://pdbe.org/2fly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [https://www.ebi.ac.uk/pdbsum/2fly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN]] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.		[https://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kotovych, G]]		[[Category: Kotovych G]]
	[[Category: Lucyk, S]]		[[Category: Lucyk S]]
	[[Category: Miskolzie, M]]		[[Category: Miskolzie M]]
	[[Category: Taha, H]]		[[Category: Taha H]]
	[[Category: Yamamoto, H]]		[[Category: Yamamoto H]]
	~~[[Category: Alpha helix]]~~
	~~[[Category: Hormone-growth factor complex~~]]

OCA at 16:06, 22 December 2021

2021-12-22T16:06:24Z

← Older revision		Revision as of 16:06, 22 December 2021
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	<StructureSection load='2fly' size='340' side='right'caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fly' size='340' side='right'caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [~~http~~://pdbe.org/2fly PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fly PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [https://pdbe.org/2fly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [https://www.ebi.ac.uk/pdbsum/2fly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN]] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.		[[https://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN]] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:51, 18 March 2020

2020-03-18T10:51:49Z

← Older revision		Revision as of 10:51, 18 March 2020
Line 1:		Line 1:

	==Proadrenomedullin N-Terminal 20 Peptide==		==Proadrenomedullin N-Terminal 20 Peptide==
	<StructureSection load='2fly' size='340' side='right' caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fly' size='340' side='right'caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Large Structures]]
	[[Category: Kotovych, G]]		[[Category: Kotovych, G]]
	[[Category: Lucyk, S]]		[[Category: Lucyk, S]]

OCA at 08:30, 14 June 2018

2018-06-14T08:30:42Z

← Older revision		Revision as of 08:30, 14 June 2018
Line 1:		Line 1:

	==Proadrenomedullin N-Terminal 20 Peptide==		==Proadrenomedullin N-Terminal 20 Peptide==
	<StructureSection load='2fly' size='340' side='right' caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fly' size='340' side='right' caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://pdbe.org/2fly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://pdbe.org/2fly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fly ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:29, 10 September 2015

2015-09-10T15:29:21Z

← Older revision		Revision as of 15:29, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://pdbe.org/2fly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fly" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:13, 25 December 2014

2014-12-25T02:13:56Z

← Older revision		Revision as of 02:13, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN]] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kotovych, G.]]		[[Category: Kotovych, G]]
	[[Category: Lucyk, S.]]		[[Category: Lucyk, S]]
	[[Category: Miskolzie, M.]]		[[Category: Miskolzie, M]]
	[[Category: Taha, H.]]		[[Category: Taha, H]]
	[[Category: Yamamoto, H.]]		[[Category: Yamamoto, H]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 15:29, 12 October 2014

2014-10-12T15:29:47Z

← Older revision		Revision as of 15:29, 12 October 2014
Line 1:		Line 1:
	[[~~Image~~:2fly.~~png\|left\|200px~~]]		==Proadrenomedullin N-Terminal 20 Peptide==
			<StructureSection load='2fly' size='340' side='right' caption='[[2fly]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FLY FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fly RCSB], [http://www.ebi.ac.uk/pdbsum/2fly PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The preferred conformation of Proadrenomedullin N-Terminal 20 Peptide (PAMP; ARLDVASEFRKKWNKWALSR-amide) has been determined using 1H and 13C two-dimensional nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. PAMP is a peptide that has various physiological functions, including its role as a proangiogenic factor in facilitating tumor growth and its inhibitory effect on catecholamine secretion at nicotinic receptors. The preferred conformation of PAMP was determined in a helix-inducing trifluoroethanol and water (TFE/H2O) solution, and in a membrane-mimetic sodium dodecylsulfate-d25 (SDS) micellar solution. The secondary structure consists of an alpha-helix for residues Arg2 to Arg20 in TFE/H2O solution and an alpha-helix for residues Arg2 to Ala17 in SDS solution. We postulate that the polar charged residues Arg2, Lys12, and Arg20 are responsible for the initial interaction of the peptide with the micelle, and that this is followed by the binding of the hydrophobic residues Leu3, Val5, Phe9, Trp13, and Trp16 to the micellar core. The three C-terminal amino acid residues adopt an extended structure in SDS, suggesting that they are important in receptor recognition and binding. This is supported by truncation studies done by Mahata et al. (Hypertension, 1998, Vol. 32, pp. 907-916), which show the importance of the C-terminal in physiological activity. Furthermore, Belloni et al. (Hypertension, 1999, Vol. 33, pp. 1185-1189), and Martinez et al. (Cancer Research, 2004, Vol. 64, pp. 6489-6494) suggested that the N-terminal was also important in PAMP activity. However, no differences in conformational preference of the N-terminal were observed between the two solvent systems.

	~~{{STRUCTURE_2fly\| PDB=2fly \| SCENE= }}~~		NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth.,Lucyk S, Taha H, Yamamoto H, Miskolzie M, Kotovych G Biopolymers. 2006 Mar;81(4):295-308. PMID:16315141<ref>PMID:16315141</ref>

	~~===Proadrenomedullin N-Terminal 20 Peptide===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16315141}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2fly]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA].~~		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kotovych, G.]]		[[Category: Kotovych, G.]]

OCA: Protected "2fly" [edit=sysop:move=sysop]

2013-01-07T14:52:38Z

Protected "2fly" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:52, 7 January 2013
(No difference)

OCA at 14:52, 7 January 2013

2013-01-07T14:52:36Z

← Older revision		Revision as of 14:52, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fly.png\|left\|200px]]		[[Image:2fly.png\|left\|200px]]

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	{{STRUCTURE_2fly\| PDB=2fly \| SCENE= }}		{{STRUCTURE_2fly\| PDB=2fly \| SCENE= }}

	===Proadrenomedullin N-Terminal 20 Peptide===		===Proadrenomedullin N-Terminal 20 Peptide===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16315141}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_16315141}}		{{ABSTRACT_PUBMED_16315141}}

	==About this Structure==		==About this Structure==
	~~2FLY is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA].		[[2fly]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLY OCA].

	~~==Reference==~~
	NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth., Lucyk S, Taha H, Yamamoto H, Miskolzie M, Kotovych G, Biopolymers. 2006 Mar;81(4):295-308. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16315141 16315141]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Kotovych, G.]]		[[Category: Kotovych, G.]]
	[[Category: Lucyk, S.]]		[[Category: Lucyk, S.]]
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	[[Category: Yamamoto, H.]]		[[Category: Yamamoto, H.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
			[[Category: Hormone-growth factor complex]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 06:55:37 2008''~~