2fp2 - Revision history

OCA at 08:00, 30 October 2024

2024-10-30T08:00:19Z

← Older revision		Revision as of 08:00, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fp2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fp2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:30, 30 August 2023

2023-08-30T09:30:53Z

← Older revision		Revision as of 09:30, 30 August 2023
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	<StructureSection load='2fp2' size='340' side='right'caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='2fp2' size='340' side='right'caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TSA:8~~-~~HYDROXY-2-OXA-BICYCLO~~[3.~~3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2fp1\|2fp1]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>~~[~~https://en~~.~~wikipedia~~.~~org/wiki/Chorismate_mutase Chorismate mutase~~], ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [https://pdbe.org/2fp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fp2 ProSAT], [https://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [https://pdbe.org/2fp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fp2 ProSAT], [https://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~SCMU_MYCTO SCMU_MYCTO]~~] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity ~~(By similarity)~~.		[https://www.uniprot.org/uniprot/SCMU_MYCTU SCMU_MYCTU] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.<ref>PMID:15654876</ref> <ref>PMID:15737998</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2fp2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2fp2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[3D structures of chorismate mutase\|3D structures of chorismate mutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Chorismate mutase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dey, R]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Grahn, E]]		[[Category: Dey R]]
	[[Category: Kast, P]]		[[Category: Grahn E]]
	[[Category: Krengel, U]]		[[Category: Kast P]]
	[[Category: Okvist, M]]		[[Category: Krengel U]]
	[[Category: Sasso, S]]		[[Category: Okvist M]]
	~~[[Category: Alpha-helical]]~~		[[Category: Sasso S]]
	~~[[Category: Isomerase~~]]

OCA at 20:39, 20 October 2021

2021-10-20T20:39:56Z

← Older revision		Revision as of 20:39, 20 October 2021
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	<StructureSection load='2fp2' size='340' side='right'caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='2fp2' size='340' side='right'caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fp1\|2fp1]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [~~http~~://pdbe.org/2fp2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fp2 ProSAT], [~~http~~://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [https://pdbe.org/2fp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fp2 ProSAT], [https://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SCMU_MYCTO SCMU_MYCTO]] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity (By similarity).		[[https://www.uniprot.org/uniprot/SCMU_MYCTO SCMU_MYCTO]] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:37, 11 December 2019

2019-12-11T19:37:36Z

← Older revision		Revision as of 19:37, 11 December 2019
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	==Secreted Chorismate Mutase from Mycobacterium tuberculosis==		==Secreted Chorismate Mutase from Mycobacterium tuberculosis==
	<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='2fp2' size='340' side='right'caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Chorismate mutase]]		[[Category: Chorismate mutase]]
			[[Category: Large Structures]]
	[[Category: Dey, R]]		[[Category: Dey, R]]
	[[Category: Grahn, E]]		[[Category: Grahn, E]]

OCA at 05:33, 8 March 2018

2018-03-08T05:33:06Z

← Older revision		Revision as of 05:33, 8 March 2018
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	==Secreted Chorismate Mutase from Mycobacterium tuberculosis==		==Secreted Chorismate Mutase from Mycobacterium tuberculosis==
	<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://pdbe.org/2fp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://pdbe.org/2fp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fp2 ProSAT], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fp2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fp2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fp2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:57, 12 September 2015

2015-09-12T00:57:20Z

← Older revision		Revision as of 00:57, 12 September 2015
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	<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://pdbe.org/2fp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~O07746_MYCTU O07746_MYCTU~~]] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity (By similarity).		[[http://www.uniprot.org/uniprot/SCMU_MYCTO SCMU_MYCTO]] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fp2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Chorismate mutase]]		[[Category: Chorismate mutase]]
	~~[[Category: Mycobacterium tuberculosis]]~~
	[[Category: Dey, R]]		[[Category: Dey, R]]
	[[Category: Grahn, E]]		[[Category: Grahn, E]]

OCA at 21:43, 25 December 2014

2014-12-25T21:43:33Z

← Older revision		Revision as of 21:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/O07746_MYCTU O07746_MYCTU]] Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Chorismate mutase]]		[[Category: Chorismate mutase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Dey, R.]]		[[Category: Dey, R]]
	[[Category: Grahn, E.]]		[[Category: Grahn, E]]
	[[Category: Kast, P.]]		[[Category: Kast, P]]
	[[Category: Krengel, U.]]		[[Category: Krengel, U]]
	[[Category: Okvist, M.]]		[[Category: Okvist, M]]
	[[Category: Sasso, S.]]		[[Category: Sasso, S]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 08:58, 30 September 2014

2014-09-30T08:58:18Z

← Older revision		Revision as of 08:58, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fp2~~.~~png~~\|~~left~~\|~~200px~~]]		==Secreted Chorismate Mutase from Mycobacterium tuberculosis==
			<StructureSection load='2fp2' size='340' side='right' caption='[[2fp2]], [[Resolution\|resolution]] 1.64Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FP2 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSA:8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC+ACID'>TSA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fp1\|2fp1]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fp2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2fp2 PDBsum], [http://www.topsan.org/Proteins/TBSGC/2fp2 TOPSAN]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fp2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The presence of exported chorismate mutases produced by certain organisms such as Mycobacterium tuberculosis has been shown to correlate with their pathogenicity. As such, these proteins comprise a new group of promising selective drug targets. Here, we report the high-resolution crystal structure of the secreted dimeric chorismate mutase from M. tuberculosis (MtCM; encoded by Rv1885c), which represents the first 3D-structure of a member of this chorismate mutase family, termed the AroQ(gamma) subclass. Structures are presented both for the unliganded enzyme and for a complex with a transition state analog. The protomer fold resembles the structurally characterized (dimeric) Escherichia coli chorismate mutase domain, but exhibits a new topology, with helix H4 of MtCM carrying the catalytic site residue missing in the shortened helix H1. Furthermore, the structure of each *MtCM protomer is significantly more compact and only harbors one active site pocket, which is formed entirely by one polypeptide chain. Apart from the structural model, we present evidence as to how the substrate may enter the active site.

	~~{{STRUCTURE_2fp2\| PDB=2fp2 \| SCENE= }}~~		1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed.,Okvist M, Dey R, Sasso S, Grahn E, Kast P, Krengel U J Mol Biol. 2006 Apr 14;357(5):1483-99. Epub 2006 Feb 6. PMID:16499927<ref>PMID:16499927</ref>

	~~===Secreted Chorismate Mutase from Mycobacterium tuberculosis===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16499927}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fp2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016499927<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Chorismate mutase]]		[[Category: Chorismate mutase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2fp2" [edit=sysop:move=sysop]

2013-01-07T13:54:31Z

Protected "2fp2" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:54, 7 January 2013
(No difference)

OCA at 13:54, 7 January 2013

2013-01-07T13:54:30Z

← Older revision		Revision as of 13:54, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fp2.png\|left\|200px]]		[[Image:2fp2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fp2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fp2\| PDB=2fp2 \| SCENE= }}		{{STRUCTURE_2fp2\| PDB=2fp2 \| SCENE= }}

	===Secreted Chorismate Mutase from Mycobacterium tuberculosis===		===Secreted Chorismate Mutase from Mycobacterium tuberculosis===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16499927}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16499927 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16499927}}		{{ABSTRACT_PUBMED_16499927}}

	==About this Structure==		==About this Structure==
	~~2FP2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA].		[[2fp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FP2 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16499927~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016499927</ref><references group="xtra"/>
	[[Category: Chorismate mutase]]		[[Category: Chorismate mutase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 33:		Line 21:
	[[Category: Sasso, S.]]		[[Category: Sasso, S.]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
			[[Category: Isomerase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 08:46:16 2009''~~