2fpf - Revision history

OCA at 08:45, 25 October 2023

2023-10-25T08:45:06Z

← Older revision		Revision as of 08:45, 25 October 2023
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	<StructureSection load='2fpf' size='340' side='right'caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2fpf' size='340' side='right'caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FPF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2fpd\|2fpd]], [[2fpe\|2fpe]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [https://pdbe.org/2fpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [https://www.ebi.ac.uk/pdbsum/2fpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fpf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [https://pdbe.org/2fpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [https://www.ebi.ac.uk/pdbsum/2fpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/JIP1_RAT JIP1_RAT]] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).		[https://www.uniprot.org/uniprot/JIP1_RAT JIP1_RAT] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Dar, I~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Gajhede, M~~]]		[[Category: Dar I]]
	[[Category: ~~Kristensen, O~~]]		[[Category: Gajhede M]]
	[[Category: ~~Ib-1]]~~		[[Category: Kristensen O]]
	~~[[Category: Islet-brain-1]]~~
	~~[[Category: Jip-1 related protein]]~~
	~~[[Category: Jrp]]~~
	~~[[Category: Mitogen-activated protein kinase 8-interacting protein 1]]~~
	~~[[Category: Scaffold protein 1]]~~
	~~[[Category: Signaling protein~~]]

OCA at 15:31, 3 March 2021

2021-03-03T15:31:04Z

← Older revision		Revision as of 15:31, 3 March 2021
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	==Crystal structure of the ib1 sh3 dimer at low resolution==		==Crystal structure of the ib1 sh3 dimer at low resolution==
	<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2fpf' size='340' side='right'caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FPF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fpd\|2fpd]], [[2fpe\|2fpe]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [~~http~~://pdbe.org/2fpf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fpf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fpf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [https://pdbe.org/2fpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [https://www.ebi.ac.uk/pdbsum/2fpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/JIP1_RAT JIP1_RAT]] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).		[[https://www.uniprot.org/uniprot/JIP1_RAT JIP1_RAT]] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Dar, I]]		[[Category: Dar, I]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]

OCA at 09:22, 14 June 2018

2018-06-14T09:22:18Z

← Older revision		Revision as of 09:22, 14 June 2018
Line 1:		Line 1:

	==Crystal structure of the ib1 sh3 dimer at low resolution==		==Crystal structure of the ib1 sh3 dimer at low resolution==
	<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://pdbe.org/2fpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://pdbe.org/2fpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fpf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fpf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fpf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fpf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:55, 12 September 2015

2015-09-12T01:55:37Z

← Older revision		Revision as of 01:55, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FPF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://pdbe.org/2fpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fpf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Dar, I]]		[[Category: Dar, I]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]

OCA at 22:19, 25 December 2014

2014-12-25T22:19:28Z

← Older revision		Revision as of 22:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FPF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FPF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/JIP1_RAT JIP1_RAT]] The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dar, I.]]		[[Category: Dar, I]]
	[[Category: Gajhede, M.]]		[[Category: Gajhede, M]]
	[[Category: Kristensen, O.]]		[[Category: Kristensen, O]]
	[[Category: Ib-1]]		[[Category: Ib-1]]
	[[Category: Islet-brain-1]]		[[Category: Islet-brain-1]]

OCA at 10:16, 30 September 2014

2014-09-30T10:16:19Z

← Older revision		Revision as of 10:16, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fpf~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the ib1 sh3 dimer at low resolution==
			<StructureSection load='2fpf' size='340' side='right' caption='[[2fpf]], [[Resolution\|resolution]] 3.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FPF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fpd\|2fpd]], [[2fpe\|2fpe]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mapk8ip1, Ib1, Jip1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fpf RCSB], [http://www.ebi.ac.uk/pdbsum/2fpf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/2fpf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Islet-brain 1 (IB1 or JIP-1) is a scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway. IB1 is expressed at high levels in neurons and in pancreatic beta-cells, where it controls expression of several insulin-secretory components and secretion. IB1 has been shown to homodimerize, but neither the molecular mechanisms nor the function of dimerization have yet been characterized. Here, we show that IB1 homodimerizes through a novel and unique set of Src homology 3 (SH3)-SH3 interactions. X-ray crystallography studies show that the dimer interface covers a region usually engaged in PxxP-mediated ligand recognition, even though the IB1 SH3 domain lacks this motif. The highly stable IB1 homodimer can be significantly destabilized in vitro by three individual point mutations directed against key residues involved in dimerization. Each mutation reduces IB1-dependent basal JNK activity in 293T cells. Impaired dimerization also results in a reduction in glucose transporter type 2 expression and in glucose-dependent insulin secretion in pancreatic beta-cells. Taken together, these results indicate that IB1 homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process.

	~~{{STRUCTURE_2fpf\| PDB=2fpf \| SCENE= }}~~		A unique set of SH3-SH3 interactions controls IB1 homodimerization.,Kristensen O, Guenat S, Dar I, Allaman-Pillet N, Abderrahmani A, Ferdaoussi M, Roduit R, Maurer F, Beckmann JS, Kastrup JS, Gajhede M, Bonny C EMBO J. 2006 Feb 22;25(4):785-97. Epub 2006 Feb 2. PMID:16456539<ref>PMID:16456539</ref>

	~~===Crystal structure~~ of the ~~ib1 sh3 dimer at low resolution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16456539}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fpf]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016456539<~~/~~ref><ref group="xtra">PMID:012756254</ref~~><~~references group="xtra"~~/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dar, I.]]		[[Category: Dar, I.]]

OCA at 12:35, 23 January 2013

2013-01-23T12:35:31Z

← Older revision		Revision as of 12:35, 23 January 2013
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	[[Image:2fpf.png\|left\|200px]]		[[Image:2fpf.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fpf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fpf\| PDB=2fpf \| SCENE= }}		{{STRUCTURE_2fpf\| PDB=2fpf \| SCENE= }}

	===Crystal structure of the ib1 sh3 dimer at low resolution===		===Crystal structure of the ib1 sh3 dimer at low resolution===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16456539}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16456539 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16456539}}		{{ABSTRACT_PUBMED_16456539}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16456539~~</ref><ref group="xtra">PMID:~~9235893</ref><ref group="xtra">PMID:9442013</ref><ref group="xtra">PMID:12756254</ref><ref group="xtra">PMID:10490659~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016456539</ref><ref group="xtra">PMID:012756254</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dar, I.]]		[[Category: Dar, I.]]

OCA: Protected "2fpf" [edit=sysop:move=sysop]

2011-03-14T22:56:16Z

Protected "2fpf" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:56, 14 March 2011
(No difference)

OCA at 22:56, 14 March 2011

2011-03-14T22:56:14Z

← Older revision		Revision as of 22:56, 14 March 2011
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	~~{{Seed}}~~
	[[Image:2fpf.png\|left\|200px]]		[[Image:2fpf.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
	~~2FPF~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA].		[[2fpf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA].

	==Reference==		==Reference==
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	[[Category: Scaffold protein 1]]		[[Category: Scaffold protein 1]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:11:24 2010''~~

OCA at 04:59, 15 December 2010

2010-12-15T04:59:05Z

← Older revision		Revision as of 04:59, 15 December 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2FPF is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA].		2FPF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FPF OCA].

	==Reference==		==Reference==
Line 36:		Line 36:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 13 10~~:45:~~22 2009~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:11:24 2010''